Effect of Nigella Sativa in Improving Blood Glucose Level in T2DM: Systematic Literature Review of Randomized Control Trials

Abstract

Background Diabetes mellitus is a highly prevalent condition that affects people of all ages, races, and genders. Medicinal herbs have received a lot of attention from researchers, and they have suggested it to be a good adjuvant to oral diabetes medications because of their combined effects. Objectives The purpose of this systematic review is to summarize the available evidences and literature of Randomized Control Trials (RCTs) on Nigella sativa (NS) in the management of Type 2 Diabetes Mellitus (T2DM). Methods A computerised database search was performed to obtain the relevant clinical trial studies. We searched the following PubMed and Google Scholar databases. Randomized controlled trials (RCTs) comparing NS versus any treatment for the management of T2DM in adults were eligible for inclusion. Results A total of 7 articles were retrieved for interpretation, complete assessment and data extraction in this systematic review. This systematic review seeks to give thorough information on the effects of NS on glucose and insulin profile status in patients with T2DM. Interpretation & Conclusion Different mechanisms are proposed which contribute to the anti-diabetic activity of NS. Various outcome parameters evaluated demonstrate a significant improvement in the management of T2DM and its complications upon intervention with NS.

Potential Benefit of Spices for Glycemic Control

“…The relative effectiveness of the form of black seed, whether oil or powder, in improving glycemic control was unclear. Differences likely were due, in part, to varied doses provided and durations of treatment, as well as to the specific glycemic outcomes measured 84,90–94 …”

“…Differences likely were due, in part, to varied doses provided and durations of treatment, as well as to the specific glycemic outcomes measured. 84,[90][91][92][93][94] Red Pepper (Capsicum annuum) Red pepper is prepared from the dried, ripened fruit of pepper plants of Capsicum species. Most commercially available red pepper is from Capsicum annuum.…”

Amputation Risk in Type II Diabetes Mellitus Patients Treated with SGLT-2 Inhibitors: A Systematic Literature Review of Randomized Clinical Trials

“…This systematic literature review was conducted as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines [18,19].…”

Effect of Nigella sativa on Selected Gastrointestinal Diseases

“…The multidirectional effects of Nigella sativa are mainly concerned with the endocrine function of the pancreas. To date, scientific reports that focussed mainly on Nigella sativa seeds and their main compound, thymoquinone, indicate their antidiabetic effects and the prevention of diabetic complications [ 26 , 27 , 28 , 29 ].…”

“…For diseases related to the exocrine function of the pancreas, thymoquinone is mainly effective at reducing pancreatic α-amylase levels, regenerating pancreatic β-cells, and alleviating pancreatitis and oxidative stress [ 25 , 38 ]. In addition, it is beneficial in reducing the factors associated with chronic pancreatitis (which may be one of the causes of pancreatic cancer) mentioned earlier, such as reducing triglycerides, weight loss, and waist circumference [ 29 ].…”