Effect of Nigella sativa oil on Schistosoma mansoni immature worms in experimentally infected mice

hamshary, A.S. Al; Nagati, Ibrahim; Eraky, Maysa Ahmad; Abououf, Eman; Kholy, Asmaa A. El; Omar, Ghada H.

doi:10.4103/bmfj.bmfj_2_18

Cited by 4 publications

(3 citation statements)

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“…Biomphalaria pfeifferi snails were collected from the irrigation canals around Federal University of Technology, Minna, from different localities in Gidan-kwanu, Minna, Niger State. Groups of 24-30 infected Biomphalaria pfeifferi snails were placed in 50 mL beakers and washed with distilled water to remove fecal and food particles from the field (Al Hamshary et al, 2018). A sample of 0.5 mL of water was viewed with used of microscope.…”

Section: Preparation Of Snailsmentioning

confidence: 99%

Cercaricidal efficacy of plant extract: evidence from the methanolic leaves and bark extracts of <i>Anacardium ocidentale</i> (Linnaeus)

Adeniyi,

Ibeh,

Oyibo-Usman

et al. 2024

dujopas

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Schistosomiasis continues to be a public health problem causing in unsatisfactorily high level of morbidity. Praziquantel is a recent medicine for treatment but unable to kill emerging schistosomes. It does not prevent re-infection and its constant application may lead to the advent of drug-resistant parasites. Qualitative phytochemical screening of the methanol crude extract of A. occidentale revealed the presence of Tannins, Flavonoids and Saponins. Cercaricidal activity on Gymnocephalous cercaria, after 120 minutes of contact in a concentration of 0.10 mg/mL, showed that there was 92 and 34% death when exposed to the methanol leave and bark extracts of A. occidentale leaves, and A. occidentale bark respectively. There was 99% and 98.5% mortality between the methanol bark extract of A. occidentale and the leaf of A. occidentale plant respectively in a concentration of 0.60mg/mL. Lethal concentration on Gymnocephalous cercariae showed that A. occidentale methanolic bark extract had the highest LC50 and LC84 of 0.151 and 0.204 mg/mL respectively while A. occidentale methanol leaf extract had the lowest LC50 and LC84 of 0.123 and 0.162 respectively. A. occidentale methanol bark extract had the lowest LC50 of 0.237 and A. occidentale methanol leaf extract had the lowest LC 84 of 0.316 mg/ml. The correlation coefficient of the plant parts showed a strong positive correlation between the log concentrations and probit mortality. The extracts had an effect on the cercariae tested. A. occidentale leaves extract showed highest cercaricidal activity. Gymnocephalous cercariae was more susceptible to the plant parts than the Brevifurcate cercaria

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Section: Preparation Of Snailsmentioning

confidence: 99%

Cercaricidal efficacy of plant extract: evidence from the methanolic leaves and bark extracts of <i>Anacardium ocidentale</i> (Linnaeus)

Adeniyi,

Ibeh,

Oyibo-Usman

et al. 2024

dujopas

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“…Additionally, it possesses antiparasitic activities as antinematodal and anticestodal capabilities in addition to activities against some protozoal infections as toxoplasmosis and Trichomonas vaginalis . (17) Its essential oil is considered one of the promising plant-based alternative medications with potent antischistosomal properties. (18) Nigella sativa in treating Schistosoma mansonai: Nigella sativa extracts contain antioxidants which found to inhibit both the host's antioxidant enzymes and the enzymes hexokinase and glucose-6-phosph-ate, which are involved in the metabolism of glucose.…”

Section: Nigella Sativamentioning

confidence: 99%

Nigella sativa loaded nanoparticles: A promising alternative treatment for murine schistosomiasis mansonai

Abd EL-Laah,

Merghny.,

ELsawy

et al. 2024

Sohag Medical Journal

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“…N. sativa possesses various beneficial compounds which confer cure for multiple diseases and disorders. Few important biological activities of N. sativa compounds include antiviral, antibacterial, anti-fungal [ 7 ], anti-inflammatory, antioxidant, anti-cancer [ 8 ], antidiabetic, anti-schistosomiasis [ 9 ], and anti-asthmatic activities.…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 Inhibitors from Nigella Sativa

Baig

Hemalatha

2022

Appl Biochem Biotechnol

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The recently encountered severe acute respiratory syndrome coronavirus 2 creates huge predicaments among various countries. Lack of specific treatment of COVID-19 disease demands urgency in drug design against SARS-CoV-2 targets. Nigella sativa the miraculous herb native to South and Southwest Asia and belonging to the family Ranunculaceae, due to its beneficial bioactive properties, was used by us for performing in silico study to analyze the potential of its compounds so that they can target and inhibit SARS-COV-2 proteins including its main protease, the papain-like protease, its helicase, and also the RNA-dependent RNApolymerase, RNA-binding protein, Endoribonuclease, receptor-binding domain, and the RNA-binding domain of nucleocapsid phosphoprotein. The procedure of molecular docking was done with the help of AutoDock–Vina 1.1.2. and along with it the ADMET properties of the best suited ligands were found and Lipinski screening was performed. Among 58 ligands screened, various compounds showed binding energy less than the standard drug chloroquine. Three compounds alpha-hederin, rutin, and nigellamine A2 had the least binding energy with the specific SARS-Cov-2 proteins suggesting their best potential as SARS-CoV-2 inhibitor. Hence, in the future, studies including the in vitro and also the in vivo studies can be carried out for analyzing their true potential and encourage use of nutraceuticals like Nigella sativa to inhibit this virus.

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Effect of Nigella sativa oil on Schistosoma mansoni immature worms in experimentally infected mice

Cited by 4 publications

References 0 publications

Cercaricidal efficacy of plant extract: evidence from the methanolic leaves and bark extracts of <i>Anacardium ocidentale</i> (Linnaeus)

Cercaricidal efficacy of plant extract: evidence from the methanolic leaves and bark extracts of <i>Anacardium ocidentale</i> (Linnaeus)

Nigella sativa loaded nanoparticles: A promising alternative treatment for murine schistosomiasis mansonai

SARS-CoV-2 Inhibitors from Nigella Sativa

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