Effect of Nigella sativa on hemodynamics, hemoglobin, and blood coagulation in patients with type 2 diabetes

Lebda, Fatma M; Bamosa, Abdullah O; Kaatabi, Huda; Al-Elq, Abdulmohsen H.; Al-Sultan, Ali Ibrahim

doi:10.7123/01.ejh.0000415060.42791.a6

Cited by 10 publications

(7 citation statements)

References 22 publications

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“…The oil and thymoquinone of N. sativa have shown potential therapeutic properties toward diabetic neuropathy (Hamdy & Taha, 2009;Kanter, 2008). There is scant human literature, however, regarding the effects of N. sativa on glycemic control in type 2 diabetes mellitus and insulin resistance syndromes (Bamosa et al, 2010;Najmi et al, 2008). Supplementation of N. sativa at a dose of 2 g/day for 3 months improved glycemic control in diabetic patients (Bamosa et al, 2010).…”

Section: Antidiabetic Activity Of Nigella Sativamentioning

confidence: 99%

“…There is scant human literature, however, regarding the effects of N. sativa on glycemic control in type 2 diabetes mellitus and insulin resistance syndromes (Bamosa et al, 2010;Najmi et al, 2008). Supplementation of N. sativa at a dose of 2 g/day for 3 months improved glycemic control in diabetic patients (Bamosa et al, 2010). N. sativa was also shown to have beneficial effects on blood glucose and lipid levels in adult subjects (Qidwai et al, 2009).…”

Section: Antidiabetic Activity Of Nigella Sativamentioning

confidence: 99%

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Designing novel industrial and functional foods using the bioactive compounds from Nigella sativa L. (black cumin): Biochemical and biological prospects toward health implications

Alu'datt,

Rababah,

Al‐u'datt

et al. 2024

Journal of Food Science

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Nigella sativa is one of the nutraceuticals that has gained popularity and studied extensively in recent decades as it is considered a safe medicinal plant for use as a dietary supplement. N. sativa contains a wide variety of bioactive substances, which include polyphenols, volatile oils (thymoquinone and p‐cymene), proteins, and peptides. The biological attributes of N. sativa include antioxidant, antimicrobial, antifungal, anti‐inflammatory, anticancer, antidiabetic, antihypertensive, hypolipidemic, and antioxidant activities, which have potential applications for the prevention of a variety of chronic diseases. In the food industry, N. sativa improves the sensory qualities, shelf life, strength, and freshness of foods, such as bread, pizza, biscuits, cookies, and cakes. This review discusses the industrial use of N. sativa, which includes processing technologies to enhance its health‐promoting properties as well as the isolation of nutraceutical components.

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Section: Antidiabetic Activity Of Nigella Sativamentioning

confidence: 99%

Section: Antidiabetic Activity Of Nigella Sativamentioning

confidence: 99%

Designing novel industrial and functional foods using the bioactive compounds from Nigella sativa L. (black cumin): Biochemical and biological prospects toward health implications

Alu'datt,

Rababah,

Al‐u'datt

et al. 2024

Journal of Food Science

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“…The feeding of NS extract decreased lipid peroxidation and increased antioxidant enzymes such as Superoxide dismutase (SOD), Catalase (CAT), and Glutathione peroxidase (GPx) in the organs of rats with chemically-induced diabetes ( 166 , 167 ). The antidiabetic benefit of ground NSS via an antioxidant-based mechanism has been proven in large-scale clinical trials involving T2DM patients ( 168 , 169 ). However, the same could not be said of NSO in such trials ( 170 , 171 ) even though NSO supplementation causes a marked reduction in oxidative stress in healthy individuals ( 172 ).…”

Section: The Role Of Herbal Medicine Formulations In Dm Treatmentmentioning

confidence: 99%

“…In a first-of-its-kind clinical trial comparing NS as monotherapy to metf in the treatment of diabetic patients, the former failed to achieve therapeutic outcomes ( 174 ). It could that the NS quantity was subtherapeutic (1,350 mg/day) since studies suggest that NS doses of less than 2 g are clinically inconsequential ( 168 ). On the basis of a meta-analysis of relevant clinical trials, the general consensus is that NS supplementation is an effective treatment for T2DM ( 175 ).…”

Section: The Role Of Herbal Medicine Formulations In Dm Treatmentmentioning

confidence: 99%

Mechanism of the antidiabetic action of Nigella sativa and Thymoquinone: a review

Shaukat,

Zaidi,

Anwar

et al. 2023

Front. Nutr.

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IntroductionLong used in traditional medicine, Nigella sativa (NS; Ranunculaceae) has shown significant efficacy as an adjuvant therapy for diabetes mellitus (DM) management by improving glucose tolerance, decreasing hepatic gluconeogenesis, normalizing blood sugar and lipid imbalance, and stimulating insulin secretion from pancreatic cells. In this review, the pharmacological and pharmacokinetic properties of NS as a herbal diabetes medication are examined in depth, demonstrating how it counteracts oxidative stress and the onset and progression of DM.MethodsThis literature review drew on databases such as Google Scholar and PubMed and various gray literature sources using search terms like the etiology of diabetes, conventional versus herbal therapy, subclinical pharmacology, pharmacokinetics, physiology, behavior, and clinical outcomes.ResultsThe efficiency and safety of NS in diabetes, notably its thymoquinone (TQ) rich volatile oil, have drawn great attention from researchers in recent years; the specific therapeutic dose has eluded determination so far. TQ has anti-diabetic, anti-inflammatory, antioxidant, and immunomodulatory properties but has not proved druggable. DM’s intimate link with oxidative stress, makes NS therapy relevant since it is a potent antioxidant that energizes the cell’s endogenous arsenal of antioxidant enzymes. NS attenuates insulin resistance, enhances insulin signaling, suppresses cyclooxygenase-2, upregulates insulin-like growth factor-1, and prevents endothelial dysfunction in DM.ConclusionThe interaction of NS with mainstream drugs, gut microbiota, and probiotics opens new possibilities for innovative therapies. Despite its strong potential to treat DM, NS and TQ must be examined in more inclusive clinical studies targeting underrepresented patient populations.

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“…In the past 2 decades, various pharmacological or medicinal aspects of N. sativa including its antibacterial [ 5 ], anticancer [ 6 , 7 ], anti-inflammatory [ 8 ], antioxidant [ 9 , 10 ], immunomodulatory [ 11 ], analgesic [ 12 , 13 , 14 ], diuretic [ 15 , 16 ], antihypertensive [ 17 ], antidiabetic [ 18 , 19 , 20 ], neuroprotective [ 16 ], gastroprotective [ 21 , 22 ], and hepatoprotective properties [ 23 ], have been reported. N. sativa has been used in clinical research for neurological disorders [ 24 , 25 , 26 ], hypertension [ 27 , 28 ], hyperlipidemia [ 29 , 30 ], obesity [ 31 , 32 ], rheumatoid arthritis [ 33 , 34 , 35 ], lung disease [ 36 ], thyroid dysfunction [ 37 ], hepatitis [ 38 ], and male infertility […”

mentioning

confidence: 99%

Nigella sativa (black seed) safety: an overview

2020

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Nigella sativa (commonly known as black seed or black cumin), from the family Ranunculaceae, is a plant that grows in countries bordering the Mediterranean Sea. This narrative review discusses the toxicological profile reported by short- to long-term studies that examined different extracts and oils of N. sativa seeds. Scientific databases including Web of Science, PubMed, Scopus, and Google Scholar were searched using appropriate keywords. LD50 for administered N. sativa seed fixed oil varied from 28.8 mL/kg to 3,371 mg/kg in mice, while 21 g/kg of aqueous, methanol, and chloroform extracts of N. sativa did not lead to any mortality. Subacute toxicity evaluations indicated that aqueous, methanol, and chloroform extracts of N. sativa at doses as high as 6 g/kg do not produce toxicity. Investigation of chronic toxicity found that 2 mL/kg of N. sativa fixed oil is slightly toxic. Cytotoxicity studies indicated that N. sativa chloroform and petroleum ether extracts are more cytotoxic than its other extracts. Although studies that assessed N. sativa toxicity generally introduced it as a safe medicinal herb, to draw a more definitive conclusion on its safety, more detailed studies must be conducted.

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Effect of Nigella sativa on hemodynamics, hemoglobin, and blood coagulation in patients with type 2 diabetes

Cited by 10 publications

References 22 publications

Designing novel industrial and functional foods using the bioactive compounds from Nigella sativa L. (black cumin): Biochemical and biological prospects toward health implications

Designing novel industrial and functional foods using the bioactive compounds from Nigella sativa L. (black cumin): Biochemical and biological prospects toward health implications

Mechanism of the antidiabetic action of Nigella sativa and Thymoquinone: a review

Nigella sativa (black seed) safety: an overview

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