Effect of Nigella Sativa Seed on Streptozotocin Induced Diabetic Reno Toxicity: Histological Observations

Abstract

Background: Diabetic nephropathy has long been recognized as the leading cause of end-stage renal disease, but the efficacy of available strategies for the prevention of Diabetic nephropathy remains poor. The aim of this study was to investigate the renoprotective effects of Nigella sativa seed and thymoquinone against streptozotocine induced renotoxicity. Materials and Methods: 24 rats were selected for this study and divided in to 4 groups each contains 6 rats, one group served as normal control, one group served as Streptozotocin (50mg/kg BW) induced diabetic control rats, one group served as diabetic rats treated with the nigella sativa seed powder(300mg/Kg body weight), one group served as diabetic rats treated with the thymoquinone(4mg/ Kg body weight). Results: Histopathological observations of present study showed that nigella sativa seed and thymoquinone treatment has proved its nephroprotective effect in streptozotocin induced diabetic rats. Conclusion: The results of present study concluding that Nigella sativa seed powder and thymoquinone having renoprotective effect in streptozotocine induced diabetic rats.