Effect of Nintedanib on healing and fibrosis in rats with experimentally induced urethral injury

Bozkurt, Muammer; Polat, E.C.; Ozcan, L.; Ozer, M.; Ozturk, G.Y.; Yildirim, F.; Otunctemur, A.

doi:10.1016/j.purol.2023.02.010

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…Nintedanib has been extensively investigated in the pathological fibrosis of lung tissue 32–34 and has also been reported in extrapulmonary tissues, such as repair after urethral injury, 35 scar formation after glaucoma surgery, 36 and pulmonary sarcoidosis combined with rheumatoid arthritis 37 . A recent report showed that nintedanib antagonizes pathological CHON‐001 chondrocyte injury in vitro 23 .…”

Section: Discussionmentioning

confidence: 99%

Nintedanib ameliorates osteoarthritis in mice by inhibiting synovial inflammation and fibrosis caused by M1 polarization of synovial macrophages via the MAPK/PI3K‐AKT pathway

Yan,

Feng,

Yang

et al. 2023

The FASEB Journal

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Synovial inflammation and fibrosis are important pathological changes associated with osteoarthritis (OA). Herein, we investigated if nintedanib, a drug specific for pulmonary fibrosis, plays a positive role in osteoarthritic synovial inflammation and fibrosis. We assessed the effect of nintedanib on osteoarthritic synovial inflammation and fibrosis in a mouse model of OA created by destabilization of the medial meniscus and a macrophage M1 polarization model created by stimulating RAW264.7 cells with lipopolysaccharide. Histological staining showed that daily gavage administration of nintedanib significantly alleviated articular cartilage degeneration, reduced the OARSI score, upregulated matrix metalloproteinase‐13 and downregulated collagen II expression, and significantly reduced the synovial score and synovial fibrosis in a mouse OA model. In addition, immunofluorescence staining showed that nintedanib significantly decreased the number of M1 macrophages in the synovium of a mouse model of OA. In vitro results showed that nintedanib downregulated the phosphorylation levels of ERK, JNK, p38, PI3K, and AKT while inhibiting the expression of macrophage M1 polarization marker proteins (CD86, CD80, and iNOS). In conclusion, this study suggests that nintedanib is a potential candidate for OA treatment. The mechanisms of action of nintedanib include the inhibition of M1 polarization in OA synovial macrophages via the MAPK/PI3K‐AKT pathway, inhibition of synovial inflammation and fibrosis, and reduction of articular cartilage degeneration.

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Section: Discussionmentioning

confidence: 99%

Nintedanib ameliorates osteoarthritis in mice by inhibiting synovial inflammation and fibrosis caused by M1 polarization of synovial macrophages via the MAPK/PI3K‐AKT pathway

Yan,

Feng,

Yang

et al. 2023

The FASEB Journal

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show abstract

“…They allocated 23 adult rats into three groups of sham, urethral injury, and urethral injury with oral Nintedanib for 14 days. After 14 days, the rat urethras were examined histopathologically and immunohistochemically and there was a significant reduction in inflammatory cell infiltration, spongiofibrosis and TGF-b and VEGF levels in the Nintedanib group (38).…”

Section: Tyrosine Kinase and Yap/taz Pathway Inhibitorsmentioning

confidence: 99%

Therapeutic adjuncts in the endoscopic management of urethral stricture disease: past, present, and future

Singh

2024

Front. Urol.

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Urethral stricture disease is a recurrent and debilitating condition affecting many men of all ages. Management may involve endoscopic or surgical treatment. Surgical urethral reconstruction remains the gold standard treatment and is associated with higher success rates in terms of stricture recurrence free-survival. However, urethroplasty is not available to patients with significant medical comorbidities, or those wishing to forego invasive surgery. Endoscopic treatment is aimed at improving lower urinary tract symptoms and relieving obstruction while maximizing time to stricture recurrence with the aid of therapeutic adjuncts. The aim of this review is to discuss the mechanism of action and role of therapeutic adjuncts and highlight some of the lesser-known adjuncts that have been utilized with success in this space.

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Effect of Oltipraz on urethral healing: An experimental study

Polat

Bozkurt

Ozcan

et al. 2023

Progrès en Urologie

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Effect of Nintedanib on healing and fibrosis in rats with experimentally induced urethral injury

Cited by 3 publications

References 24 publications

Nintedanib ameliorates osteoarthritis in mice by inhibiting synovial inflammation and fibrosis caused by M1 polarization of synovial macrophages via the MAPK/PI3K‐AKT pathway

Nintedanib ameliorates osteoarthritis in mice by inhibiting synovial inflammation and fibrosis caused by M1 polarization of synovial macrophages via the MAPK/PI3K‐AKT pathway

Therapeutic adjuncts in the endoscopic management of urethral stricture disease: past, present, and future

Effect of Oltipraz on urethral healing: An experimental study

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