Effect of nitrazepam and flurazepam on the ventilatory response to carbon dioxide.

Geddes, Duncan M.; Rudolf, Michael; Saunders, K.B.

doi:10.1136/thx.31.5.548

Cited by 31 publications

(9 citation statements)

References 19 publications

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“…Other benzodiazepines, including flurazepam, lorazepam and diazepam, have been shown to suppress respiratory function in patients with chronic obstructive pulmonary disease (COPD) [Denaut et al 1974;Geddes et al 1976]. The purpose of this study was to evaluate the effects of a therapeutic dose of estazolam on pulmonary and cardiac function in patients with COPD during both awake and sleep states.…”

Section: Discussionmentioning

confidence: 99%

Effects of Estazolam and Flurazepam on Cardiopulmonary Function in Patients with Chronic Obstructive Pulmonary Disease

1992

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Benzodiazepine drugs have been shown to suppress respiratory function in patients with chronic obstructive pulmonary disease (COPD). We designed a placebo-controlled crossover study to compare the effects of a new benzodiazepine, estazolam ('ProSom'), with those of flurazepam ('Dalmane') on cardiopulmonary function in COPD patients. 29 patients completed all treatment phases (estazolam 2 mg, flurazepam 30 mg or placebo). Respiratory and cardiovascular function were assessed in awake patients on days 1 and 5 (acute and cumulative effects). Eight patients were also assessed during sleep in each period. The effects of estazolam and flurazepam on ventilatory response to CO2 and mouth occlusion pressure were no different from those of placebo. However, acute administration of flurazepam lowered tidal volume and increased inspiratory flow. Although no clinical signs of respiratory depression were observed with any long term treatment, flurazepam decreased oxygen saturation and inspiratory time and increased respiratory frequency. Neither drug altered breathing control during sleep. Our results indicate that estazolam 2 mg is equally as safe a hypnotic agent as flurazepam for patients with mild COPD.

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Section: Discussionmentioning

confidence: 99%

Effects of Estazolam and Flurazepam on Cardiopulmonary Function in Patients with Chronic Obstructive Pulmonary Disease

1992

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“…Rao et al (1973) (1973) demonstrated respiratory depressive activity of 5 to 10 mg oral doses of nitrazepam in patients with chronic obstructive lung disease. Geddes et al (1976) showed no significant decrease in sensitivity to carbon dioxide following 5 mg oral doses of nitrazepam in six subjects with and six without chronic bronchitis. However, in the same study, a 15 mg oral dose of flurazepam produced a significant decrease in CO2 sensitivity in both groups.…”

Section: Assessment Of the Ventilatory Control Systemmentioning

confidence: 77%

Hypnotics and the control of breathing: a review.

Ma¹

1983

Brit J Clinical Pharma

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“…Diazepam, 5 mg orally, causes depression of the ventilatory response to carbon diox ide in healthy volunteers [8] as well as mouth occlusion pressure in patients with chronic airflow obstruction [1], Fluorazepam, 15 mg orally produces a significant decrease in carbon dioxide sensitivity in normal subjects and patients with chronic bronchitis [3]. Temazepam, 40 mg orally, causes significant reduction of the ventila tory response to carbon dioxide in healthy volunteers [5] Thus, brotizolam appears to be a safe hypnotic leaving no sequelae and causing no respiratory suppression in healthy vol unteers.…”

Section: Discussionmentioning

confidence: 99%

“…Brotizolam is a new triazolothienodiazepine hypnotic, 2-bromo-4-(2-chlorophenyl)-9-methyl-6H-thieno-[3,2-f)-1,2,4-triazolo-[4,3-a]-l,4-diazepine, with an eli mination half-life of about 4.4 h. It is con sidered useful in the management of in somnia when sequelae must be avoided [4], Although all central nervous system de pressants suppress respiration when given in sufficient doses, similar compounds, the benzodiazepines, have been shown to produce both depression or stimulation of the respiratory center [3]. The purpose of 1 Supported by Boehringer Ingelheim Ltd. : The author thanks S. Birch, B.S., and B. Marchetie, B.S., for their technical assistance.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Brotizolam, a New Hypnotic, on Cardiac and Respiratory Function in Volunteers

Cohn¹

1984

Respiration

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In a double-blind, cross-over study we measured the effect of a 0.5-mg oral dose of brotizolam, a new thienodiazepine hypnotic, on cardiac and respiratory functions in 12 healthy volunteers. No deleterious effects on pulse, blood pressure, forced vital capacity, forced expiratory volume in 1 s, respiratory rate, mouth occlusion pressure (P_0.1) and ventilatory responses to carbon dioxide occurred over a 6-hour period. In the usual therapeutic dose, brotizolam does not suppress cardiac and respiratory functions in healthy volunteers.

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Effect of nitrazepam and flurazepam on the ventilatory response to carbon dioxide.

Cited by 31 publications

References 19 publications

Effects of Estazolam and Flurazepam on Cardiopulmonary Function in Patients with Chronic Obstructive Pulmonary Disease

Effects of Estazolam and Flurazepam on Cardiopulmonary Function in Patients with Chronic Obstructive Pulmonary Disease

Hypnotics and the control of breathing: a review.

The Effects of Brotizolam, a New Hypnotic, on Cardiac and Respiratory Function in Volunteers

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