Effect of nitric oxide inhibition in Bacillus Calmette-Guerin bladder cancer treatment

Langle, Yanina; Balarino, Natalia Patricia; Belgorosky, Denise; Morgado, P; Sandes, Eduardo Omar; Marino, Lina; Bilbao, Erica Rojas; Zambrano, Macarena; Lodillinsky, Catalina; Eiján, Ana María

doi:10.1016/j.niox.2020.03.003

Cited by 8 publications

(2 citation statements)

References 31 publications

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“… 146 Likewise, the NOS inhibitor NG‐monomethyl‐ l ‐arginine ( l ‐NMMA) and N (G)‐nitro‐ l ‐arginine methyl ester ( l ‐NAME) can increase the number of CD8 + T cells and NK cells while decreasing Treg and MDSCs accumulation. 95 , 147 Furthermore, down‐regulating mTOR in CD11b + Gr‐1 + MDSCs induced iNOS expression and increased NO production, which mediated a protective effect in IMH. 54 Direct and indirect inhibition of CEBPβ or STAT3 also reduces iNOS and Arg1 levels in T‐MDSCs.…”

Section: Therapeutic Applications Target On Mdscs Metabolismmentioning

confidence: 99%

“…The Arg1 inhibitor N‐hydroxy‐ l ‐arginine (NOHA) reversed T cell dysfunction both in vitro and in tumor‐bearing mice, and led to an anti‐tumor response 146 . Likewise, the NOS inhibitor NG‐monomethyl‐ l ‐arginine ( l ‐NMMA) and N (G)‐nitro‐ l ‐arginine methyl ester ( l ‐NAME) can increase the number of CD8 + T cells and NK cells while decreasing Treg and MDSCs accumulation 95,147 . Furthermore, down‐regulating mTOR in CD11b + Gr‐1 + MDSCs induced iNOS expression and increased NO production, which mediated a protective effect in IMH 54 .…”

Section: Therapeutic Applications Target On Mdscs Metabolismmentioning

confidence: 99%

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Metabolic reprogramming of myeloid-derived suppressor cells: An innovative approach confronting challenges

et al. 2021

Journal of Leukocyte Biology

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Immune cells such as T cells, macrophages, dendritic cells, and other immunoregulatory cells undergo metabolic reprogramming in cancer and inflammation-derived microenvironment to meet specific physiologic and functional demands. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that are characterized by immunosuppressive activity, which plays a key role in host immune homeostasis. In this review, we have discussed the core metabolic pathways, including glycolysis, lipid and fatty acid biosynthesis, and amino acid metabolism in the MDSCs under various pathologic situations. Metabolic reprogramming is a determinant of the phenotype and functions of MDSCs, and is therefore a novel therapeutic possibility in various diseases.

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