“…The therapeutic potential of alpha acids has been investigated for their wide range of bioactivity against bacteria, osteoporosis, angiogenesis, inflammation and cancer as comprehensively reviewed (Van Cleemput et al, 2009;Karabín et al, 2016). Furthermore, alpha acids were found to exhibit sedative and hypnotic properties (Zanoli et al, 2005;Schiller et al, 2006), indicating their major role in hops' sleeppromoting activity previously reported in animal models (Bravo et al, 1974;Lee et al, 1993;Franco et al, 2012aFranco et al, , 2014 and humans (Vonderheid-Guth et al, 2000;Dimpfel and Suter, 2008;Franco et al, 2012b). This activity is attributed to the positive modulation of γ-aminobutyric acid type A (GABA A ) receptor function demonstrated earlier with hops extracts (Aoshima et al, 2006;Sahin et al, 2016) and alpha acid fractions (Benkherouf et al, 2020).…”