Effect of Non-Ionic Detergents on the Absorption of Fat and &lt;i&gt;α&lt;/i&gt;-Tocopherol in the Rat

Mj, Sheltaway; Ms, Lowosky

doi:10.1159/000175604

Cited by 8 publications

(2 citation statements)

References 9 publications

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“…In children with a normal intake of dietary fat, five of seven tested had fecal fat over five g/day while consuming cholestyramine that significantly exceeded their basal fecal fat excretion [44]. Cholestyramine has been used to produce a model of fat malabsorption in animals [45][46][47], and cholestyramine in excess doses can bring about malabsorption in humans [48]. In animal and human studies, chitosan and the viscous fiber, glucomannon, have been shown to have effects on bile acid excretion [49,50].…”

Section: Chitosan and Bile Acid Bindingmentioning

confidence: 99%

Chitosan as a Dietary Supplement for Weight Loss: A Review

Kaats¹

2006

CNF

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Obesity is a serious health problem not only in the United States but also throughout the world. It is generally recognized that complications of the overweight state and obesity are responsible for thousands of deaths each year, because excess fat accumulation is associated with heart disease, stroke, and diabetes that significantly reduce life expectancy. Many have come to realize that most individuals, especially when elderly, require aids to prevent or overcome obesity and maintain a reasonable body fat mass. A restricted caloric diet and regular exercise remain the cornerstones of prevention and therapy; however, the average overweight individual cannot sustain the necessary therapeutic disciplines and needs safe, complementary means to supplement diet and exercise. Up to this point, drugs are not the answer due to safety concerns, leading many to seek safer, natural alternatives. Recently, oral intake of chitosan, a soluble fiber with reputed special properties, has become one possible solution to the problem. This review examines chitosan as an aid in the battle against fat accumulation.

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Section: Chitosan and Bile Acid Bindingmentioning

confidence: 99%

Chitosan as a Dietary Supplement for Weight Loss: A Review

Kaats¹

2006

CNF

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“…Low-fat diets are disliked by patients; and desiccated bile preparations may worsen diarrhea, even if they improve steatorrhea (2). Attempts to use synthetic detergents such as nonionic surfactants have had only modest success (14)(15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Physicochemical and physiological properties of cholylsarcosine. A potential replacement detergent for bile acid deficiency states in the small intestine.

Lillienau¹,

Schteingart²,

Hofmann³

1992

J. Clin. Invest.

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The properties of cholylsarcosine (the synthetic N-acyl conjugate ofcholic acid with sarcosine IN-methylglycinel) were examined to determine its suitability as a bile acid replacement agent for conditions of bile acid deficiency in the small intestine, which causes fat malabsorption. Previous studies in rodents had shown that the compound was well transported by the liver and ileum and underwent neither deconjugation nor dehydroxylation during enterohepatic cycling. By 'H-nuclear magnetic resonance, cholylsarcosine was found to exist in dilute aqueous solution as an almost equimolar mixture of two geometric isomers-cis and trans (around the amide bond)-in contrast to cholylglycine, which was present entirely in the trans form. The critical micellization concentration was 11 mmol/liter, similar to that of cholylglycine (10 mmol/liter). By nonaqueous titrimetry, the pK; of cholylsarcosine was 3.7, only slightly lower than that of cholylglycine (3.9).

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Effect of surfactants on weight gain in mice

Kaneene

Ross

1986

Vet Res Commun

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A study was conducted to determine if four surfactants can induce increased weight gain in the mouse. Basic-H, Triton X-100, Amway All Purpose Adjuvant and X-77 were put in water and fed to various groups of ICR 21 day old female mice for a period of 43 days. All the mice were clinically normal throughout the study period. Pathological examination of a random sample of the mice revealed no gross pathological changes. Similarly, histopathological examination of the lungs, livers and intestines did not reveal any visible lesions. Basic-H and Amway surfactants induced weight gain, though not significantly, better at 0.1% (V/V) concentration while X-77 and Triton X-100 induced weight gain better at 0.4% (V/V) concentration. Overall results show that none of the surfactants tested induced significant weight gain.

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Effect of Non-Ionic Detergents on the Absorption of Fat and <i>α</i>-Tocopherol in the Rat

Cited by 8 publications

References 9 publications

Chitosan as a Dietary Supplement for Weight Loss: A Review

Chitosan as a Dietary Supplement for Weight Loss: A Review

Physicochemical and physiological properties of cholylsarcosine. A potential replacement detergent for bile acid deficiency states in the small intestine.

Effect of surfactants on weight gain in mice

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