The effect of the generalized (r, q) distribution on the non-linear propagation of dust acoustic waves (DAWs) in a dusty plasma consisting of variable-size dust grains is discussed. A Korteweg-de Vries (KdV) equation is derived using the reductive perturbation technique (RPT). The dust size obeys the power-law dust size distribution (DSD). The present results reveal that rarefactive and compressive waves can propagate in the proposed plasma model. It is found that the spectral indices r and q influence the main properties of DAWs. Especially, the velocity, amplitude, and width of the DAW change drastically with r compared to changes in q.