Effect of non surgical periodontal therapy and vitamin C supplementation on total antioxidant capacity in patients with chronic generalised periodontitis – A randomised controlled trial

Nisha, Swet; Shivamallu, Avinash Bettahalli; Prashant, Akila; Shashikumar, Pratibha; Ganganna, Aruna; Das, Debaprasad

doi:10.1016/j.jobcr.2023.05.003

Cited by 11 publications

(4 citation statements)

References 37 publications

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“…Cassiano et al also showed the association between periodontitis and ultra-processed food consumption [40]. There are also many studies concluding the relationship between periodontitis and serum levels of vitamins such as vitamin D [41] or vitamin C [42]. Parallelly investigators try to assess the influence of vitamins and other supplements intake on the outcomes of the periodontitis treatment and/or progression [43][44][45].…”

Section: Discussionmentioning

confidence: 99%

A Case Control Study Evaluating the Relationship between Vitamin K2 Serum Level and Periodontitis

Olszewska-Czyz,

Firkova

2023

Healthcare

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Background and Aim: Vitamin K2 (VK2) is an essential co-factor for bone metabolism. There is still very little data regarding possible VK2 relation to periodontitis. This study aimed to investigate any potential link between VK2 serum level and the severity of periodontitis in comparison to a control group of healthy individuals. The trial was performed on 100 patients among whom 50 were diagnosed with periodontitis. The patients underwent full clinical periodontal and radiological examination. The VK2 serum level was assessed using the ELISA kit (Gla-type osteocalcin EIA Kit, Takara, Kusatsu). Patients with periodontitis had mean serum levels of VK2 significantly lower (0.27 ± 0.06 nmol/L; p < 0.001) than the control group (0.43 ± 0.09 nmol/L; p < 0.001) regardless of the patient’s age or sex. The VK2 serum level decreased with the severity of periodontitis with the lowest level in stage IV of the disease (0.19 ± 0.01 nmol/L; p < 0.001). Also, a significant drop was noticed between the grades of periodontitis. Individuals with localized forms of the disease had significantly lower VK2 levels (0.26 ± 0.006 nmol/L; p < 0.001) in comparison to subjects with generalized periodontitis (0.30 ± 0.01 nmol/L; p < 0.001). The VK2 serum levels were also associated with most of the clinical parameters such as bleeding on probing (−0.805, 95% CI: −0.894 to −0.654, p < 0.001), attachment loss (−0.752, 95% CI: −0.862 to −0.574, p < 0.001), and bone loss (−0.656, 95% CI: −0.801 to −0.439, p < 0.001). In the present study, the VK2 serum level was correlated to periodontitis, and its severity, complexity, extension, and grade. The range of VK2 was decreasing together with the worsening of all clinical parameters of periodontitis.

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Section: Discussionmentioning

confidence: 99%

A Case Control Study Evaluating the Relationship between Vitamin K2 Serum Level and Periodontitis

Olszewska-Czyz,

Firkova

2023

Healthcare

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“…Immunostaining in the gingival tissue of rats with experimentally induced periodontitis and diabetes [71] showed that vitamin C reduces the following: (a) tissue advanced glycation end products (AGEs), involved in hyperinflammatory response, oxidative stress, and bone destruction [67] and (b) matrix metalloproteinases-8, responsible for the degradation of type 1 collagen in supportive periodontal tissue [71], showing immunomodulatory activity, tissue damage protection, as well as tissue repair promotion, reaffirming the therapeutic potential of vitamin C for periodontal disease treatment. However, a randomized controlled trial did not prove that a supplemental dose of vitamin C, along with nonsurgical periodontal therapy, in chronic periodontitis patients has benefits [72], highlighting the need for further studies.…”

Section: Vitamin C-related Patents In Periodontal Diseasesmentioning

confidence: 99%

“…Moreover, people may respond differently to antioxidant treatments, due to variations in their metabolism, genetics, and the specific nature of their periodontal disease; the optimal duration of antioxidant treatment for periodontal disease needs to be clearly defined, to establish consistent guidelines for clinical practice. For instance, a randomized controlled trial failed to show any benefit of adding a supplemental dose of vitamin C to nonsurgical periodontal therapy for chronic periodontitis patients [72].…”

Section: Challenges and Limitations Of Using Antioxidants To Treat An...mentioning

confidence: 99%

Patent Mining on the Use of Antioxidant Phytochemicals in the Technological Development for the Prevention and Treatment of Periodontitis

Juiz,

Ferreira,

Pires

et al. 2024

Antioxidants

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Periodontal disease is an inflammatory condition characterized by an aberrant immune response against a dysbiotic dental biofilm, with oxidative stress performing an essential role in its pathogenesis. This paper presents a patent mining, performed in the Orbit Intelligence patent database, related to antioxidant phytochemicals in the technological developments that are working to prevent and treat periodontal disease. To access the documents, the descriptors “PERIODONTAL” and “ANTIOXIDANT” were typed in the title, abstract, and claim search fields. A total of 322 patents demonstrate the growing interest in researching natural antioxidants for scientific and technological purposes. The top ten countries regarding the number of family patents produced were the United States, the European Office, Japan, South Korea, China, India, Mexico, Denmark, Canada, and Great Britain. The most cited compounds were vitamin C, green tea, quercetin, melatonin, lycopene, resveratrol, and curcumin. These compounds have been used for the technological development of gels, membranes, dentifrices, chewing gum, orally disintegrating film, mouthwash, mouth spray, and mouth massage cream and exhibit the ability to neutralize free radicals and reduce oxidative stress, a critical factor in the development and progression of periodontal diseases. The patent documents have shown that using antioxidant compounds in conjunction with traditional periodontal treatments is a promising area of interest in periodontal therapy.

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“…A periodontite se manifesta pela perda significativa de tecidos de suporte dos dentes, incluindo o osso alveolar e os ligamentos periodontais, podendo, em última instância, levar à mobilidade dentária e à perda dos dentes afetados. (NISHA et al, 2023) A prevalência da doença periodontal é alarmante, afetando uma grande proporção da população adulta mundial. Estudos epidemiológicos indicam que aproximadamente metade da população adulta global enfrenta algum grau de doença periodontal.…”

Section: Desenvolvimentounclassified

I Jornada Caicoense De Fortalecimento Da Rede De Proteção Integral E Prevenção De Violência Contra Mulheres: Relato De Experiência

Maia,

Silva,

Nogueira

et al. 2023

Educação, Saúde E Direitos Humanos: Abordagens Que Promovem Qualidade De Vida

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Todos os direitos garantidos. Este é um livro publicado em acesso aberto, que permite uso, distribuição e reprodução em qualquer meio, sem restrições desde que sem fi ns comerciais e que o trabalho original seja corretamente citado. Este trabalho está licenciado com uma Licença Creative Commons DECLARAÇÃO DOS AUTORESOs autores desta obra assumem publicamente a responsabilidade pelo seu conteúdo, garantindo que o mesmo é de autoria própria, original e livre de plágio acadêmico. Os autores declaram, ainda, que o conteúdo não infringe nenhum direito de propriedade intelectual de terceiros e que não há nenhuma irregularidade que comprometa a integridade da obra. Os autores assumem integral responsabilidade diante de terceiros, quer de natureza moral ou patrimonial, em razão do conteúdo desta obra. Esta declaração tem por objetivo garantir a transparência e a ética na produção e divulgação do livro. Cumpre esclarecer que o conteúdo de cada artigo é de responsabilidade exclusiva dos autores, não refletindo, necessariamente, a opinião da editora, organizadores da obra ou do conselho editorial.

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Effect of non surgical periodontal therapy and vitamin C supplementation on total antioxidant capacity in patients with chronic generalised periodontitis – A randomised controlled trial

Cited by 11 publications

References 37 publications

A Case Control Study Evaluating the Relationship between Vitamin K2 Serum Level and Periodontitis

A Case Control Study Evaluating the Relationship between Vitamin K2 Serum Level and Periodontitis

Patent Mining on the Use of Antioxidant Phytochemicals in the Technological Development for the Prevention and Treatment of Periodontitis

I Jornada Caicoense De Fortalecimento Da Rede De Proteção Integral E Prevenção De Violência Contra Mulheres: Relato De Experiência

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