Effect of non-surgical periodontal therapy on the degree of gingival inflammation and stress markers related to pregnancy

Abstract

ObjectivesThe purpose of this study was to determine the impact of nonsurgical periodontal therapy considering the salivary stress-related hormone and cytokine levels in the gingival crevicular fluid (GCF) on pregnant and nonpregnant women.Material and MethodsThirty non-pregnant (control group) and 30 pregnant women (test group) that met the study inclusion criteria were chosen. Only participants with gingivitis were included. Clinical data and samples of GCF and saliva were collected at baseline and after periodontal therapy. The levels of interleukin-1 beta (Κ-1β) and IL-10, and concentration of salivary chromogranin A (CgA) hormone were analyzed by enzyme-linked immunosorbent assay (ELISA). The repeated measures analysis of variance was used for intragroup and intergroup analyses.ResultsA major decrease in the gingival inflammation was observed in both groups after periodontal therapy (p<0.05). Periodontal treatment decreased the level of IL-1β in GCF (p<0.05) in control group, but no statistical difference was determined for GCF IL-1β in the test group. However, after periodontal therapy, the CgA hormone concentration was reduced in both groups (p<0.05). However, there was no difference in salivary CgA concentration, GCF IL-10 levels, and perceived stress scale (PSS)-10 between the groups (p>0.05).ConclusionsWithin the limitations of this study, periodontal therapy significantly improved the periodontal status and stress level. In addition, the severity of the gingival inflammation during pregnancy was related to stress. However, further studies will be needed to substantiate these early findings.

Análise da Saúde Periodontal e Qualidade de Vida de Gestantes Atendidas pelo SUS no Município de Maceió, Alagoas

“…Além da suscetibilidade à inflamação decorrente de alterações moleculares nos níveis de mediadores do FCG, pode haver o aumento da suscetibilidade individual à infecção, com a inibição da função de linfócitos, macrófagos e monócitos. As alterações hormonais e fisiológicas podem também aumentar os níveis de estresse levando ao aumento dos níveis de hormônios relacionados ao estresse que podem implicar na produção de citocinas próinflamatórias e afetar a DP (20). Foi observado que 34% das gestantes apresentaram código OHIP-14 acima da média, o que pode estar relacionado a fatores como ausência de dentes, presença de sangramento ou cálculo dentário e hábito de fumar.…”

Dampak dan Terapi Non-Farmakologis Periodontitis pada Ibu Hamil; Kajian Literatur

“…Turki. (Yarkac et al, 2018). Tedapat sejumlah 9 artikel jurnal yang menjadi bahan review dalam studi laporan sistematik review ini.…”

A systematic review of chromogranin A (CgA) and its biomedical applications, unveiling its structure-related functions

“…The very first application of CgA was to detect neuroendocrine tumors (NETs), as illustrated by a pioneering study in 1986 that demonstrated a sensitivity of 81% and a specificity of 100% for the diagnosis of a pheochromocytoma [1]. Since then, several biomarkers have been developed and are commercially available [20,149,150].…”