Effect of non‐surgical periodontal treatment with or without doxycycline on the periodontium of type 1 diabetic patients

Llambés, Fernando; Silvestre, Francisco-Javier; Hernández‐Mijares, Antonio; Guiha, Rami; Caffesse, Raúl G.

doi:10.1111/j.1600-051x.2005.00736.x

Cited by 50 publications

(61 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mean PPD and mean CAL is a continuous variable to evaluate periodontal disease severity (22), other authors have used discontinuous variables classifying this disease in low threshold periodontitis (mild periodontal disease) and high threshold periodontitis (advanced disease) (23). Mean PPD and mean CAL are a pretty accurate ways of evaluating periodontal disease severity and these values were correlated with hs-CRP levels to find any relationship.…”

Section: Discussionmentioning

confidence: 99%

Efect of periodontal disease and non surgical periodontal treatment on C-reactive protein. Evaluation of type 1 diabetic patients

Llambés

Silvestre²,

Hernández‐Mijares³

et al. 2012

Med Oral

View full text Add to dashboard Cite

Objectives: The purpose of this study was to analyze how anti-infectious periodontal treatment affects C reactive protein (CRP) values in patients with type 1 diabetes, and correlate baseline CRP levels with periodontal disease severity. Study Design: A cohort of fifty three subjects with type 1 diabetes and moderate to severe periodontitis were recruited. Periodontal parameters were measured, and blood samples were obtained to evaluate high-sensitivity C-reactive protein (hs-CRP). Group 1 was treated with scaling, root planning, and systemic administration of doxycycline. Group 2 received only scaling and root planning. Results: Hs-CRP was reduced after periodontal treatment in group 1 (-0.22 mg/l) and 2 (-0.21 mg/l ) but this reduction was not statistically significant, even in the patients with the best response to periodontal treatment. However, significant correlation appeared between hs-CRP and mean probing pocket depth (PPD) (p=0, 01) and mean clinical attachment level (CAL) (p=0,03). Conclusions: Non-surgical periodontal treatment couldn’t reduce hs-CRP values, however, it was found an association between advanced periodontitis and elevated blood hs-CRP levels in patients with type 1 diabetes. It can be speculated that periodontal disease increases production of pro-inflammatory mediators in patients with type 1 diabetes, but other producing sources of these pro-inflammatory substances may exist. Key words:Periodontal disease, periodontitis, diabetes mellitus type 1, periodontal therapy, C reactive protein.

show abstract

Section: Discussionmentioning

confidence: 99%

Efect of periodontal disease and non surgical periodontal treatment on C-reactive protein. Evaluation of type 1 diabetic patients

Llambés

Silvestre²,

Hernández‐Mijares³

et al. 2012

Med Oral

View full text Add to dashboard Cite

show abstract

“…96 Doxycycline, a broad-spectrum antimicrobial agent, is a tetracycline derivative which has been The properties of doxycycline seem to be useful in periodontal therapy because of its antibacterial, anti-collagenolytic, anti-inflammatory effects, and fibroblast-stimulating activities. 106,107 Doxycycline was able to inhibit in vitro osteoclastogenesis and cause apoptosis of mature osteoclasts due to bone resorption. These effects extend beyond the mere inhibition of MMP.…”

Section: Doxycyclinesmentioning

confidence: 99%

“…Moreover, administration of doxycycline additional to periodontal therapy has the potential to alter diabetes metabolic control. 107,121,122 Also it has stated that doxycycline inhibits non-enzymatic glycation of extracellular proteins, and it may have a similar effect on the glycation of hemoglobin. 123 Several studies suggest that the administration of systemic doxycycline can result in improvement of metabolic control especially in poorly controlled type 2 DM periodontitis patients.…”

Section: The Use Of Doxycycline In Diabetes Mellitus With Periodontalmentioning

confidence: 99%

“…122,123,125 Moreover, the use of systemic doxycycline as adjunctive therapy in Type 1 DM patients with periodontitis did not improve levels of glycemic control. 107,126 Deo et al 127 evaluated the clinical efficacy of LDD together with SRP in DM patients with CP. They concluded that combined SRP and LDD therapy was more effective than SRP alone in terms of clinical attachment gain and probing depth reduction in DM patients with severe periodontal disease.…”

Section: The Use Of Doxycycline In Diabetes Mellitus With Periodontalmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Bisphosphonates and Low-Dose Doxcycline Therapy in Diabetics With Periodontitis: A Review

Doğan¹,

Dede²

2016

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

View full text Add to dashboard Cite

“…[58][59][60] Furthermore, reports show that use of systemic antibiotics as an adjunct to SRP may be more beneficial for diabetic patients. Two studies reported that use of systemic doxycycline 100 mg for two weeks provided better reductions in PD, 61,62 Porphyromonas gingivalis, and glycated hemoglobin (HbA 1c ) levels. 61 when compared with diabetics receiving mechanical therapy alone.…”

mentioning

confidence: 99%

Treating chronic periodontitis: current status, challenges, and future directions

Shaddox¹

2010

CCIDE

View full text Add to dashboard Cite

Periodontitis affects roughly one-third of the US population. A timely diagnosis of chronic periodontitis at its earliest stage is essential to avoid more challenging severe stages of the disease. Most cases of slight and moderate chronic periodontitis can be successfully managed by mechanical removal and/or reduction of subgingival bacterial biofilms and calculus. However, any factor that affects either the local environment or the host response may contribute to progression of the disease and a poor treatment response. Thus, it is essential that clinicians are aware of etiologic and risk factors associated with disease development and progression in order to plan and execute a successful treatment. This paper reviews a variety of risk factors, both local and systemic, that can impact the successful treatment of chronic periodontitis.

show abstract

Effect of non‐surgical periodontal treatment with or without doxycycline on the periodontium of type 1 diabetic patients

Abstract: Although both periodontal treatment regimens are effective in type 1 diabetics, the use of doxycycline as an adjunct, provided more significant results when good plaque control was achieved.

Cited by 50 publications

References 39 publications

Efect of periodontal disease and non surgical periodontal treatment on C-reactive protein. Evaluation of type 1 diabetic patients

Efect of periodontal disease and non surgical periodontal treatment on C-reactive protein. Evaluation of type 1 diabetic patients

The Effect of Bisphosphonates and Low-Dose Doxcycline Therapy in Diabetics With Periodontitis: A Review

Treating chronic periodontitis: current status, challenges, and future directions

Contact Info

Product

Resources

About