Effect of Nonionic Surfactant on Bactericidal Activity of Cetylpyridinium Chloride

Relationships between Estimates of Binding of Antimicrobial Agents by Macromolecules, based on Physicochemical and Microbiological Data: Cetylpyridinium Chloride and Polyethylene Glycol

“…The hypothesis is clearly an over-simplification. From other work Bradshaw et al, 1972) it seems that different models are needed to explain the interactions between preservatives and macromolecules of different types. So far, work on 3 different pairs of antimicrobial agents and antagonists has revealed 3 different patterns of interaction.…”

“…We commenced a programme of work (Humphreys, Richardson & Rhodes, 1968;Bradshaw, Rhodes & Richardson, 1972) which we hoped, by using the more precise though laborious technique of viable count determination of bactericidal activity, would allow a better comparison between data from microbiological and physicochemical sources and without the possibility of interference by external ingredients in the binding reaction. Results with the systems benzoic acid: Texofor 830, an 72-alkylpolyoxyethylene surfactant and CPC : Polysorbate 80 (Bradshaw et al, 1972) have already been reported and this paper reports results obtained in the system CPC : PEG 20 BI. This last system was in part chosen to allow a comparison of the effect of rnicellar (Polysorbate 80) and nonrnicellar (PEG) association on antimicrobial activity.…”