Effect of Nonsteroidal Anti-Inflammatory and Other Pharmacological Agents on Tuberculin Reaction

Guidelines for the prevention and management of Mycobacterium tuberculosis infection and disease in adult patients with chronic kidney disease

“…However, it is well known that this test lacks sensitivity, especially in patients on dialysis, with reported anergy rates of up to 50% 20–23. Immunosuppressants used as treatment for kidney disease and in transplantation (including prednisolone, azathioprine, cyclophosphamide, ciclosporin, tacrolimus or mycophenolate mofetil and newer monocloncal antibodies) interfere with the accuracy of the TST 24. Chemoprophylaxis for LTBI itself carries a small risk of adverse events in patients with normal renal function, particularly of drug-induced hepatitis which increases with age and is occasionally fatal.…”

Guidelines for the prevention and management of Mycobacterium tuberculosis infection and disease in adult patients with chronic kidney disease

“…20e23 Immunosuppressants used as treatment for kidney disease and in transplantation (including prednisolone, azathioprine, cyclophosphamide, ciclosporin, tacrolimus or mycophenolate mofetil and newer monocloncal antibodies) interfere with the accuracy of the TST. 24 Chemoprophylaxis for LTBI itself carries a small risk of adverse events in patients with normal renal function, particularly of druginduced hepatitis which increases with age and is occasionally fatal. There are no equivalent data for patients with CKD.…”