Effect of novel arecoline thiazolidinones as muscarinic receptor 1 agonist in Alzheimer's dementia models

The pharmacology, toxicology and potential applications of arecoline: a review

“…Later, Ono's research suggested that arecoline could attenuate the impairment of mealtime-associated activity related to ''temporal learning'' in old rats (Ono et al 1995). Recent investigation revealed that as an M receptor agonist, arecoline could also reverse scopolamine-induced memory loss and learning impairment in male AD rats (Chandra et al 2008). Thus, arecoline, the main active constituent of AN, might be used to ameliorate learning and memory for old people who are suffered AD related diseases.…”

Synthesis of 1,2-benzisoxazole tethered 1,2,3-triazoles that exhibit anticancer activity in acute myeloid leukemia cell lines by inhibiting histone deacetylases, and inducing p21 and tubulin acetylation

“…20,21 Also, benzisoxazole was evaluated for their ability to function as substrates for recombinant human NAD(P)H:quinone oxidoreductase that upregulated in cancer cells. 22 In continuation of our effort to synthesize various bioactive heterocycles including 3-substituted-1,2-benzisoxazole compounds, [23][24][25][26][27][28][29][30][31][32][33] we in this work report the synthesis of a novel series of 1,2,3-triazoles tethered to the third position of the 1,2-benzisoxazole heterocycle, and furthermore examined their cytotoxic effect on cervical cancer and acute myeloid leukemia (AML) cells. The synthesis, biological evaluation, as well as computational and experimental mode-of-action analysis of those compounds is described in the following…”

Arecoline inhibits intermediate-conductance calcium-activated potassium channels in human glioblastoma cell lines

“…The neuroprotective effects of ARE was found in Alzheimer's disease (Chandra et al, 2008;Sadashiva et al, 2009;Maezawa et al, 2011;Lee et al, 2013). It stimulates production of connective tissue growth factor in human buccal mucosal fibroblasts and induces HaCaT cell apoptosis (Deng et al, 2009;Li et al, 2014).…”