Effect of novel mucoadhesive buccal patches of carvedilol on isoprenaline-induced tachycardia

Verma, Navneet; Chattopadhyay, Pronobesh

doi:10.4103/2231-4040.133436

Cited by 10 publications

(3 citation statements)

References 19 publications

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“…The linear chain of PVA allows the formation of hydrogen bonds between the OH groups of neighboring chains and this tends to pack the polymer molecules in a compact structure even if the polymer structure is not regular (Ochiai et al., 1974 ). The swelling index was found to decrease significantly when the percentage of PVA in the film is increased (Singh et al., 2014 ; Verma & Chattopadhyay, 2014 ).…”

Section: Resultsmentioning

confidence: 99%

Formulation and optimization of duloxetine hydrochloride buccal films: in vitro and in vivo evaluation

2017

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Duloxetine hydrochloride (DH) is a serotonin-norepinephrine reuptake inhibitor (SSNRI) indicated for the treatment of depression. Duloxetine suffers from reduced oral bioavailability (≈50%) due to hepatic metabolism. This study aims to develop DH buccoadhesive films to improve its bioavailability. DH buccoadhesive films were prepared adopting the solvent casting method using hydroxypropyl methylcellulose (HPMC) and polyvinyl alcohol (PVA). The prepared films were evaluated for weight uniformity, drug content, surface pH, swelling index, mucoadhesion strength and drug release percentages. Accelerated stability and bioavailability studies in healthy human volunteers were also performed for the selected films. Results of the evaluation tests showed that the optimum physicochemical characters were obtained by the films prepared with 2% HPMC using 10% propylene glycol (F2 films). Accelerated stability studies revealed that DH showed proved stability throughout the experiment time. DH bioavailability from F2 films was determined and compared with that of the marketed oral capsules (Cymbalta 30 mg). The pharmacokinetic results showed that C for F2 was higher than the market product. In addition, ANOVA analysis showed that a T of F2 film was significantly lower, while, the AUC of F2 was significantly higher than that of Cymbalta capsules. The percentage relative bioavailability of DH from F2 was found to be 296.39%. Therefore, the prepared buccal films offer an alternative route for the administration of DH with the possibility of improving its bioavailability.

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Section: Resultsmentioning

confidence: 99%

Formulation and optimization of duloxetine hydrochloride buccal films: in vitro and in vivo evaluation

2017

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“…The films were left in 10 ml of distilled water for one hour at room temperature, allowed to swell, and pH was determined by bringing the electrode in contact with the surface of the film for one minute [39].…”

Section: Measurement Of Film's Surface Phmentioning

confidence: 99%

Design, Development, and Characterization of Loratadine Sustained Released Buccal Film: In Vitro and in Vivo Study in Beagle Dogs

ABDOUN,

ALTUWAYJIRI,

ALFURAYDI

et al. 2024

Int J App Pharm

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Objective: The aim of this work was to develop and evaluate bucco-adhesive films of Loratadine (LTD) for sustained release use. Methods: Design of twelve different sustained released buccal film formulas using Carbopol, pectin, sodium alginate, glycerol, carboxymethyl cellulose (CMC), hydroxypropyl cellulose (HPC), Gelatin, Hydroxyethyl cellulose (HEC), and Hydroxypropyl methylcellulose (HPMC) as mucoadhesive polymers. Films were evaluated for physicochemical properties, thickness, swelling, moisture content, drug content, in vitro dissolution. The pharmacokinetic parameters of optimal formula were evaluated in beagle dogs. Results: The selected film formula (F6) showed accepted content and muco-adhesion properties. The in vitro release study showed prolonged release of drug from films over 10 h in optimal formulation. The bioavailability studies performed using beagle dogs model showed that there was 113.45% increase in the AUC0-24 of selected film compared with oral market tablets. Conclusion: Bucco-adhesive films is a promising dosage form for improving the bioavailability of loratadine.

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“…The average drug content is estimated. [28] 10] In-vitro Release studies: Using a few drops of phosphate buffer solution, a 2×2 cm2 sample was put onto a microscope slide to examine the release rate of active components (pH 6.8). The slide was then positioned at a 45° angle in a 250 ml beaker with 100 ml of pH 6.8 phosphate buffer solution and kept in a water bath with circulating water that was held at 37°C.…”

Section: ] Extrusion Of Hot Meltmentioning

confidence: 99%

Mucoadhesive Buccal Films

H J,

Kulkarni,

Paarak

2023

JCPP

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Pharmaceutical formulations are experiencing a significant transformation as novel drug delivery techniques become increasingly available and effective. While there are many different types of medical dosage forms, each has its own limitations, such as tablet choking and painful parenteral dosages. Buccal drug delivery, which involves administering medication to the oral cavity, offers a convenient and easy-to-administer alternative. The oral route of medication administration has numerous benefits, including avoiding liver metabolism, enhancing drug bioavailability, and improving the onset of action. By directly entering the systemic circulation, active pharmaceutical ingredients can produce their therapeutic effects. As the buccal mucosa has a high degree of permeability and blood supply, it is a highly accessible drug delivery system. There are six theories that explain mucosal adhesion: electronics, wettability, adsorption, degradation, diffusion, and mechanics. Various in vitro and in vivo approaches have been used to study buccal drug delivery systems. This paper discusses the mechanisms of action, mucosal adhesion theories, and standard techniques for producing films. Key areas of study in buccal drug delivery systems include evaluating films for weight variation, thickness, folding endurance, surface pH, percentage of moisture absorption and loss, tensile strength, swelling index, content uniformity, and in vitro permeation studies.

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Effect of novel mucoadhesive buccal patches of carvedilol on isoprenaline-induced tachycardia

Cited by 10 publications

References 19 publications

Formulation and optimization of duloxetine hydrochloride buccal films: in vitro and in vivo evaluation

Formulation and optimization of duloxetine hydrochloride buccal films: in vitro and in vivo evaluation

Design, Development, and Characterization of Loratadine Sustained Released Buccal Film: In Vitro and in Vivo Study in Beagle Dogs

Mucoadhesive Buccal Films

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