Background/Aim: The fracture of engine-driven instruments during root canal treatment has been tried to be eliminated by developing the manufacturing process of the files. The aim of this study was to assess cyclic fatigue resistance (CFR) of the two different rotary filesEdgeSequel™ Sapphire (ES) and Race® Evo (RE)which are produced by two different manufacturing technologies. Material and Methods: While RE is manufactured from heat-treated NiTi alloy with the electropolished surface, ES undergoes a non-disclosed thermal treatment called FireWire heat treatment. The CFRs of ES and RE comprising of similar tip size and taper (15/.04 and 25/.04) were compared on a cyclic fatigue device with an artificial stainless-steel canal (60° curvature, 5 mm radius, 1.5 mm width, and 3.0 mm depth). The continuous water spray with a syringe at 35.5°C was used to decrease the friction and to simulate in vivo conditions. All procedures were performed at recommended speed and torque for both files until fracture occurred. The time to failure (TF) was recorded and the number of cycles to failure (NCF) was calculated. The Weibull calculations (Weibull modulus, R2, predicted cycles, and time for 99 % survival) for NCF and TF were also done. The data were statistically analyzed with the independent two-sample t-test and the paired two-sample t-test. The significance level was set at p < 0.05. Results: Both ES and RE showed a better CFR in 15/.04 tip size than 25/.04 (P < 0.05). The TF of the ES were higher than the RE (P < 0.05). The highest and lowest Weibull modulus values were obtained with RE 15/.04 and RE 25/.04, respectively. Conclusions: Both the tip diameter and alloy modification of the instruments affected the CFR. FireWire heat treatment was associated with longer TF. The bigger the tip diameter, the lower the CFR for both tested products.