Effect of Nurse-Led Goal-Directed Lung Physical Therapy on the Prognosis of Pneumonia in Sepsis Patients in the ICU: A Prospective Cohort Study

Sun, Jian; Han, Wen; Cui, Na; Li, Qi; Wang, Hao; Li, Zunzhu; Luo, Hongbo; Liu, Jinbang

doi:10.1177/0885066620987200

Cited by 6 publications

(11 citation statements)

References 26 publications

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“…However, there is little evidence for the effect of nurse-led GDLPT on the prognosis of pneumonia in older patients with sepsis. In a previous study, we found that nurse-led GDLPT improved the outcomes in patients with sepsis and pneumonia ( 11 ). In this study, we carried out a retrospective analysis of older patients (age ≥ 65 years) with sepsis and pneumonia to evaluate whether GDLPT affects the clinical outcome.…”

Section: Introductionmentioning

confidence: 89%

“…The GDLPT study was a prospective, two-phase (before-and-after) study conducted in Peking Union Medical College Hospital of China from January 2017 to January 2020. Details of this study, including the inclusion and exclusion criteria, have been published previously ( 11 ). The study period was divided into two stages of phase 1 and phase 2.…”

Section: Methodsmentioning

confidence: 99%

“…The protocols for pneumonia in the pre- and post-protocol groups are shown in Figure 2 . Details of this study, including study details such as the intervention objective, methods, and intervention frequency, were the same as those in our previous study ( 11 ). The Supplementary File provides additional evidence relevant to the intervention and comparisons.…”

Section: Methodsmentioning

confidence: 99%

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Implementation of Nurse-Led, Goal-Directed Lung Physiotherapy for Older Patients With Sepsis and Pneumonia in the ICU

et al. 2021

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Objectives: This study aimed to investigate the effect of nurse-led, goal-directed lung physiotherapy (GDLPT) on the prognosis of older patients with sepsis caused by pneumonia in the intensive care unit.Methods: We conducted a prospective, two-phase (before-and-after) study over 3 years called the GDLPT study. All patients received standard lung therapy for sepsis caused by pneumonia and patients in phase 2 also received GDLPT. In this study, 253 older patients (age ≥ 65 years) with sepsis and pneumonia were retrospectively analyzed. The main outcome was 28 day mortality.Results: Among 742 patients with sepsis, 253 older patients with pneumonia were divided into the control group and the treatment group. Patients in the treatment group had a significantly shorter duration of mechanical ventilation [5 (4, 6) vs. 5 (4, 8) days; P = 0.045], and a lower risk of intensive care unit (ICU) mortality [14.5% (24/166) vs. 28.7% (25/87); P = 0.008] and 28 day mortality [15.1% (25/166) vs. 31% (27/87); P = 0.005] compared with those in the control group. GDLPT was an independent risk factor for 28 day mortality [odds ratio (OR), 0.379; 95% confidence interval (CI), 0.187–0.766; P = 0.007].Conclusions: Nurse-led GDLPT shortens the duration of mechanical ventilation, decreases ICU and 28-day mortality, and improves the prognosis of older patients with sepsis and pneumonia in the ICU.

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Section: Introductionmentioning

confidence: 89%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Implementation of Nurse-Led, Goal-Directed Lung Physiotherapy for Older Patients With Sepsis and Pneumonia in the ICU

et al. 2021

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“…However, there is little evidence for the effect of nurseled GDLPT on the prognosis of pneumonia in older patients with sepsis. In a previous study, we found that nurse-led GDLPT improved the outcomes in patients with sepsis and pneumonia (11). In this study, we carried out a retrospective analysis of older patients (age ≥ 65 years) with sepsis and pneumonia to evaluate whether GDLPT affects the clinical outcome.…”

Section: Introductionmentioning

confidence: 95%

“…The GDLPT study was a prospective, two-phase (before-andafter) study conducted in Peking Union Medical College Hospital of China from January 2017 to January 2020. Details of this study, including the inclusion and exclusion criteria, have been published previously (11). The study period was divided into two stages of phase 1 and phase 2.…”

Section: Study Design and Patientsmentioning

confidence: 99%

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Association of onset-to-surgery time with morbidity and mortality among patients with perforated peptic ulcer: an observational cohort study

Tan

Heng

et al. 2022

Preprint

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Background Rapid surgery is recommended to improve outcomes after peptic ulcer perforation (PPU), but understanding of the optimal onset-to-surgery time for PPU is limited. The purpose of this study was to assess the optimal time of onset to surgery for PPU that improved patient outcomes. Methods Data of eligible patients with PPU at three hospitals from 2019 to 2021 were retrospectively reviewed. Patients were categorized as a onset-to-surgery time of ≤ 12 h (early surgery [ES]) or > 12 h (late surgery [LS]). The primary outcome was 30-day sepsis morbidity. Secondary outcomes included 30-day postoperative morbidity and 30-day mortality. Patients’ characteristics and surgical outcomes were also compared. A P value of < 0.05 is considered as statistically significant. Results Of 245 patients, 231 (94.3%; mean [SD] age, 62.6 [18.2] years; 153 [70.5%] male)were included in the final analysis. Among the remaining cases, 50.7% underwent ES and 49.3% underwent LS. LS was associated with increased sepsis morbidity within 30 days (ORadj 5.71, 95% CI 2.02–16.10, P = 0.001). In secondary analyses, LS was associated with an increased risk of postoperative morbidity (ORadj 1.93, 95% CI 1.06–3.53, P = 0.032). The 30-day mortality was 0.9% in the ES group and 4.7% in the LS group (ORadj 3.93, 95% CI 0.43–36.05, P = 0.227). In addition, the estimated blood loss during ES was significantly less than that during LS (P = 0.004). The operative time and hospital stay were shorter in the ES group (both P < 0.005). Moreover, patients in the LS group were more likely to need for ICU admission (39.3% vs 22.7%, P = 0.008). Conclusions This cohort study found evidence that more favorable outcomes were achieved when surgery was performed within 12 hours after the onset of severe abdominal pain among patients with PPU. These findings provide more clarity around the optimal time of onset to surgery for patients with PPU. However, more well powered researches are needed to confirm the findings.

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Effect of Nurse-Led Goal-Directed Lung Physical Therapy on the Prognosis of Pneumonia in Sepsis Patients in the ICU: A Prospective Cohort Study

Cited by 6 publications

References 26 publications

Implementation of Nurse-Led, Goal-Directed Lung Physiotherapy for Older Patients With Sepsis and Pneumonia in the ICU

Implementation of Nurse-Led, Goal-Directed Lung Physiotherapy for Older Patients With Sepsis and Pneumonia in the ICU

Table_1.DOCX

Association of onset-to-surgery time with morbidity and mortality among patients with perforated peptic ulcer: an observational cohort study

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