Background: Dyslexia is a vague hidden disorder that interferes with children's learning process. Parents are the primary caregivers for their children and have a great influence on their children's academic success. Unfortunately, the majority of them do not have the appropriate knowledge to assist their children, impacting negatively on the parents, the child and the whole family. Parents' awareness of dyslexia and its impact on their children is imperative in ensuring the sustainable development of the children. Aim: The present study aimed to assess parents' knowledge and attitudes regarding dyslexia among their children. Design: A cross-sectional survey design was utilized in the current study. Setting: The study was conducted in EtayAlbaroad General Hospital outpatient clinics. Sample: A convenient sample of 952 parents participated in the current survey over two months. Tools: Two tools were utilized during the study; the first tool was a dyslexia knowledge questionnaire, which was divided into two parts: part one: parents' sociodemographic data, and part two: parents' knowledge about dyslexia. The second tool was a structured attitude scale. Results: The current study results showed that more than half of parents had unsatisfactory level of knowledge toward their children's dyslexia and the majority of them had a negative attitude toward their children's dyslexia. Moreover, there were a highly statistical significant relation between knowledge and attitude among dyslexic children's parents. Conclusion: The study concluded that parents didn't have enough knowledge to start early intervention which affected their attitude toward their children, and there weren't suitable, accessible, and affordable governmental places to educate parents about all learning disabilities. Recommendations: Develop wide policies and practices by the Egyptian Ministry of Health that suggest setting up educational intervention programs is important considering parental awareness, needs, and resources, thus moving, within a systemic perspective, from an individual-cantered to a family-centered care viewpoint.