An investigation on the efficacy of paddy residue and nutrient management approaches on growth, yield and nutrient uptake by paddy was conducted during kharif and rabi-summer seasons of 2019-20 and 2020-21 at Gabbur village, Raichur, Karnataka, India. The experiment was laid out in split plot design with three replications, which consisted of four residue management in main plots and five nutrient management approaches in sub plots. The treatment with residue incorporation + compost culture gave significantly taller plants (84.40 and 84.53 cm), higher number of tillers hill-1 (20.06 and 20.09), grain yield (65.37 & 65.34 q ha-1), straw yield (80.01 & 80.04 q ha-1) and total N, P, K, S, Zn & Fe uptake over residue incorporation alone, residue burning and residue removal. Similarly, application of nutrients through SSNM targeted yield of 80 q ha-1 gave significantly higher plant height (90.51 and 90.50 cm), higher number of tillers hill-1 (23.02 and 22.95), grain yield (75.19 & 75.26q ha-1), straw yield (92.17 & 92.14 q ha-1) and total N, P, K, S, Zn & Fe uptake followed by STCR targeted yield of 80 q ha-1 > STL method > recommended NPK > absolute control. Interaction effect showed that, residue incorporation + compost culture with SSNM targeted yield of 80 q ha-1 recorded significantly higher plant height (95.95 and 96.13), number of tillers hill-1(25.50 and 25.56), grain yield (77.25 and 77.45 q ha-1), straw yield (94.83 and95.32 q ha-1) and nutrient uptake by paddy over other combinations.