Effect of Nutrition on the Production of Acute Disseminated Encephalomyelitis in Mice

Schneider, Howard A.; Lee, Johanna M.; Olitsky, Peter K.

doi:10.1084/jem.105.4.319

Cited by 18 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The failure of animals to develop EAE in the absence of certain essential nutrients has also been observed by Schneider, Lee, and Olitsky (18) who found that the susceptibility of an inbred mouse strain to EAE induction was less on a purified diet than on fox chow, bread, and milk. The susceptibility was partially restored by supplementation of the purified diet with folic acid, vitamin B12, and biotin.…”

Section: Discussionsupporting

confidence: 53%

“…1 further demonstrates the effect of scurvy on development of skin sensitivity to tuberculin. Guinea pigs were tested with PPD 11, 15, and 21 days after injection with 0.1 mg of dried Mycobacterium butyricum in an aquaphor-water-oil emulsion (18,22, and 28 days after beginning the scorbutogenic diet). A normal non-sensitized control group was also included.…”

Section: Determination Of Plasma 17-hydroxycorticosteroids--17-hydromentioning

confidence: 99%

See 1 more Smart Citation

Prevention of Experimental Allergic Encephalomyelitis (Eae) by Vitamin C Deprivation

Kies

Alvord

Shaw

1962

The Journal of Experimental Medicine

View full text Add to dashboard Cite

Scorbutic guinea pigs injected with CNS and mycobacterium to induce experimental allergic encephalomyelitis (EAE) showed no clear-cut neurological signs and failed to show histological evidence of central nervous system damage. The degree of protection afforded by vitamin C deprivation was related directly to the duration of the scorbutogenic diet and inversely to the strength of the CNS challenge. Vitamin C deprivation also abolished tuberculin sensitivity as measured by the PPD skin reaction. Upon restoration of vitamin C, the animals recovered their sensitivity to PPD but did not develop EAE. It was further demonstrated that these effects of vitamin C deprivation were not related to inanition or to the endogenous levels of 17-hydroxycorticosteroids.

show abstract

Section: Discussionsupporting

confidence: 53%

Section: Determination Of Plasma 17-hydroxycorticosteroids--17-hydromentioning

confidence: 99%

Prevention of Experimental Allergic Encephalomyelitis (Eae) by Vitamin C Deprivation

Kies

Alvord

Shaw

1962

The Journal of Experimental Medicine

View full text Add to dashboard Cite

show abstract

“…Text- Fig. 1 shows this variation, and while the indicated periodicity is itself not meaningful, it assumes more importance when considered in the light of another, quite different experience, namely that the lung disease reported in this mouse strain by Schneider et al (14) showed almost exactly similar periodicity. Although this is circumstantial evidence it nevertheless coincides well with the basic idea of the infection hypothesis.…”

Section: Epideraiological Studiesmentioning

confidence: 87%

The Extension of the Shwartzman Phenomenon to the Mouse and Some Ecological Determinants of the Single-Injection Reaction

Arndt

Schneider

1960

The Journal of Experimental Medicine

Self Cite

View full text Add to dashboard Cite

The localized Shwartzman reaction has been demonstrated in a highly inbred mouse strain (BSVS). This reaction was produced with marked regularity in these mice by administration of relatively small doses of bacterial endotoxin or other Shwartzman-active agents. It is considered the equivalent of the phenomenon described in the rabbit inasmuch as it has conformed to all the operational and histopathological aspects of the classical reaction that have been tested, including elicitation by various endotoxins, heterologous preparation and provocation, inhibition by anticoagulants, and provocation by antigen-antibody complexes. A reaction similar to the above but differing in its manner of production was also investigated and has been termed the single-injection Shwartzman reaction. This phenomenon was identical with the normal Shwartzman reaction in all ways except for the fact that it was elicited with but a single intradermal injection of bacterial endotoxin. In investigating the lesion it has been demonstrated that inapparent in the gross, but elicitible infection of the lungs with a Gram-negative microflora was uniformly associated with single-injection reactivity. Because of this constant association it has been suggested that a causal relationship exists between the infected state and the skin reaction, not on the basis of known immunological events but on the basis of the Shwartzman mechanism in which the lung flora, demonstrably excited by the preparative injection, appears to mediate natural "endogenous" provocation of the lesion at the prepared skin sites.

show abstract

Multiple Sclerosis and Nutrition

Alter¹,

Yamoor²,

Harshe³

1974

Archives of Neurology

View full text Add to dashboard Cite

Demonstration of similarities in geographic distribution of multiple sclerosis (MS) and component of diet would strengthen a consideration that diet plays a causal role in MS. Prevalence of MS in many countries was correlated with average daily per capita consumption of fats and oils, protein, and calories, including calories of animal origin. Of these dietary factors, only calories of animal origin and fats and oils correlated significantly with MS prevalence. When the latter two were combined (animal-fats), a significant correlation with MS prevalence of .70 resulted, suggesting that increased consumption of animal-fat may be associated with MS. Experimental and clinical observations relating diet to increased adhesiveness of formed blood elements, to biochemical alteration of central myelin, and to impaired delayed hypersensitivity are plausible mechanisms linking risk of MS to high animal-fat consumption. (Arch Neurol 31:267-272, 1974) Many investigators13 have sug¬ gested that nutrition plays a role in causing multiple sclerosis (MS). If there were a relationship between a dietary factor and the cause of MS, then one should be able to show similarities in the geographic distribution of MS and that dietary factor. In this study, we examined nutrition in various parts of the world and correlated MS frequency with the distribution of several components of diet. MethodsInformation on nutrition has been pub¬ lished by the Statistical Yearbook of the United Nations for several decades.4 Re¬ cent dietary information from 120 coun¬ tries was used for this report and was ex¬ pressed in terms of the average daily per capita consumption of four factors: total calories, total protein (in grams), calories of animal origin (as percent of total calo¬ ries), and fats and oils (in grams). Earlier dietary data were also reviewed but were available on fewer countries. It was appre¬ ciated that even the more recent data were crude, but intensive dietary surveys in six countries (Japan, Finland, Yugoslavia, Greece, the Netherlands, and Italy) agreed well with the crude estimates for these same countries5 and enhanced confidence in the validity of the dietary data.Information on MS frequency was de¬ rived from studies of prevalence in welldefined populations." Prevalence of MS was plotted against geographic latitude and a strong positive association clearly existed (Fig 1); ie, MS tended to increase in preva¬ lence with geographic latitude. When these points were plotted by computer as a parabolic function, a good fit resulted. However, considerable scatter was evi¬ dent. Alternative mathematical distribu¬ tion models using the same data have been discussed by Alter et al.7 From these stud¬ ies, 22jttvmtrie3_WEre_£ele£ted_f ormation on both_MS._pre.valence anrLdiet was available. areas had good medical facilities and readily available information on de¬ mographic characteristics of the popu¬ lation. The case-findmg_jn_ethods in each area were fairly well standardized and in¬ volved examin^tionjrfjr^ejicjaLrficords in hospitaj ...

show abstract

Effect of Nutrition on the Production of Acute Disseminated Encephalomyelitis in Mice

Cited by 18 publications

References 17 publications

Prevention of Experimental Allergic Encephalomyelitis (Eae) by Vitamin C Deprivation

Prevention of Experimental Allergic Encephalomyelitis (Eae) by Vitamin C Deprivation

The Extension of the Shwartzman Phenomenon to the Mouse and Some Ecological Determinants of the Single-Injection Reaction

Multiple Sclerosis and Nutrition

Contact Info

Product

Resources

About