Effect of nutritional status on arsenic and smokeless tobacco induced genotoxicity, sperm abnormality and oxidative stress in mice <i>in vivo</i>

Das, Samrat; Langthasa, Pimily; Barhoi, Dharmeswar; Upadhaya, Puja; Giri, Sarbani

doi:10.1002/em.22188

Cited by 12 publications

(5 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study proved that Chamaemelum nobile extract maintains antioxidant defense systems and does not affect lipid peroxidation since there is no significant variation in the EA group compared to the control one. Sensitization by OVA showed a very high significant increase (p ≤0.001) of MDA levels in the lungs and erythrocytes, and a very high significant decrease (p ≤0.001) of the non-enzymatic antioxidant activity of reduced glutathione (GSH) which represents one of the many antioxidant defenses which is a factor involved in the protection of various organs against the damages that are induced by oxidants during the inflammatory process (44). Its reduction is due to its high use by GST in the detoxification of H2O2 and the detoxification of active metabolites through the involvement of GPx.…”

Section: Discussionmentioning

confidence: 99%

In-vivo anti-inflammatory effects of Roman Chamomile (Chamaemelum nobile) aqueous extracts collected from the National Park of El-Kala (North-East, Algeria)

Mustapha Hichem Zadam,

Meriem Ahmida,

Nesrine Djaber

et al. 2023

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

The aim of our study is to evaluate anti-inflammatory effect of Chamaemelum nobile. Aqueous extracts were administrated to Wistar rats in bronchial-inflammation experimentally induced by an allergen and ovalbumin, administered intraperitoneally / intranasally (20mg/kg/day). Experimentation showed disturbances in bronchoalveolar fluid with increased leukocyte and lymphocyte levels as well as IL-4 concentration in the lungs and erythrocytes associated with high lipid peroxidation. There were disturbances in enzymatic and non-enzymatic antioxidant defense system. Lungs histopathological showed an inflammatory lymphoplasmacytic infiltrate, moderate edema of alveoli, vascular congestion and suffusion hemorrhage. Administration of aqueous extract to OVA-sensitized rats caused a significant and very highly significant improvement of MDA levels in lungs, erythrocytes, GSH, GPx, GST, catalase and SOD. We notice a decrease in IL-4 in LBA and lungs alongside reduced inflammatory cell infiltration, mild bronchiolar dilation, mild alveolar edema and normal cell morphology allowing us to conclude on the effectiveness of anti-inflammatory activity of Roman chamomile.

show abstract

Section: Discussionmentioning

confidence: 99%

In-vivo anti-inflammatory effects of Roman Chamomile (Chamaemelum nobile) aqueous extracts collected from the National Park of El-Kala (North-East, Algeria)

Mustapha Hichem Zadam,

Meriem Ahmida,

Nesrine Djaber

et al. 2023

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

show abstract

“…Due to the local geological features, arsenic can be found in natural water sources including rivers and groundwater. For instance, arsenic in groundwater is a substantial public health concern in many regions of South Asia [22,23].…”

Section: Drinking Watermentioning

confidence: 99%

“…Organ damage and possible death are possible in acute arsenic intoxication. On the other hand, malignant tumors may develop as a result of the deformity of the extremities brought on by long-term exposure to arsenic [23,27]. Ingestion and inhalation are the two most common ways to be exposed to arsenic, and these are also the ways that cause health issues most commonly.…”

Section: Arsenic-induced Toxicity In Human Healthmentioning

confidence: 99%

Consequences of arsenic exposure in Plant-health status: an overview

Nath Barbhuiya,

Warisa,

Barhoi

et al. 2023

Arsenic in the Environment - Sources, Impacts and Remedies

Self Cite

View full text Add to dashboard Cite

Arsenic is the biggest threat to all living organisms across the world. It is typically present in very minute amounts in rock, soil, air, and water, but these levels are rising as a result of both natural and man-made activity. Exposure to arsenic increases the risk of developing liver, lung, kidney, and bladder malignancies as well as vascular illnesses such as stroke, ischemic heart disease, and peripheral vascular disease. Arsenic generates oxidative stress, which disrupts the redox balance. In fact, in plants arsenic gets accumulated in different parts of plants upon exposure to either contaminated soil or water, causing hazardous effects on the plant. Therefore, this chapter is aimed to understand the effect of arsenic exposure on the growth and development of the plant as a whole.

show abstract

“…The cytogenotoxic potential of either AN or SG has been studied in Chinese hamster ovarian cells (Dave et al, 1992a), oral mucosal fibroblast (Jeng et al, 2001), human buccal epithelial cells (Sundqvist et al, 1989; Kausar et al, 2009; Das et al, 2022; Giri et al, 2021), human blood lymphocytes (Dave et al, 1992b; Kumpawat et al, 2003; Giri et al, 2021), and mouse bone marrow cells (Kumpawat et al, 2003, Das et al, 2016, Das et al, 2018; Das et al, 2022). However, the role of AN and SG‐mediated genotoxicity and cytotoxicity alone or in combination during early embryonic development has not been studied to date.…”

Section: Introductionmentioning

confidence: 99%

Areca nut and smokeless tobacco exposure induces micronucleus, other nuclear abnormalities and cytotoxicity in early chick embryo

Mandal

Talukdar

Das

et al. 2023

Birth Defects Research

Self Cite

View full text Add to dashboard Cite

Areca nut (AN) and smokeless tobacco (SLT) are indiscriminately consumed among the populations of Southeast and South Asian countries, even by women during the gestational period. This study aimed to investigate the genotoxic and cytotoxic potentials of AN and Sadagura (SG), a unique homemade SLT preparation, alone and in combination in early chick embryos. Fertile white leghorn chicken eggs were randomly divided into five treatment groups: vehicle control, positive control (Mitomycin C, 20 μg/egg), AN, SG, and AN +SG. AN, SG, and AN+SG were given at dosages of 0.125, 0.25, and 0.5 mg/ egg. The hen's egg test for micronucleus induction (HET-MN) was performed in chick embryos to evaluate the genotoxic potential of the test agents. Furthermore, the cytotoxic potential was assessed by studying erythroblast cell populations and the polychromatic erythrocytes (PCEs) to normochromatic erythrocytes (NCEs) ratio. Our results indicated a significant increase (p < .001) in MN frequency and other nuclear abnormalities, suggesting the potential of AN and SG to cause genotoxicity. Also, AN and SG exposure alone and in combination considerably altered the erythroblast cell population (%) and the PCE to NCE ratio in all the treatment periods. Our findings established the genotoxic and cytotoxic potential of both AN and SG alone and in combination during early embryonic development in the chick embryo.

show abstract

Effect of nutritional status on arsenic and smokeless tobacco induced genotoxicity, sperm abnormality and oxidative stress in mice in vivo

Cited by 12 publications

References 41 publications

In-vivo anti-inflammatory effects of Roman Chamomile (Chamaemelum nobile) aqueous extracts collected from the National Park of El-Kala (North-East, Algeria)

In-vivo anti-inflammatory effects of Roman Chamomile (Chamaemelum nobile) aqueous extracts collected from the National Park of El-Kala (North-East, Algeria)

Consequences of arsenic exposure in Plant-health status: an overview

Areca nut and smokeless tobacco exposure induces micronucleus, other nuclear abnormalities and cytotoxicity in early chick embryo

Contact Info

Product

Resources

About