Effect of nutritional supports on malnutrition, cognition, function and biomarkers of Alzheimer’s disease: a systematic review

Kocatürk, Rümeysa Rabia; Temizyürek, Arzu; Özcan, Öznur Özge; Ergüzel, Türker Tekin; Karahan, Mesut; Konuk, Muhsin; Tarhan, Nevzat

doi:10.1080/00207454.2022.2079506

Cited by 6 publications

(8 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…with similar effect sizes, although not all diets & studies are equal (Kocatürk et al, 2022). Neither the significance or effect size of the COCOA multimodal intervention should be surprising in light of these reports.…”

Section: Discussionmentioning

confidence: 81%

“…Several other case reports and case series similarly support the importance and effect size of multimodal interventions (e.g., Ross et al, 2021; Toups et al, 2022). Even dietary interventions alone have been reported with similar effect sizes, although not all diets & studies are equal (Kocatürk et al, 2022). Neither the significance or effect size of the COCOA multimodal intervention should be surprising in light of these reports.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A multimodal intervention for Alzheimer’s disease results in multifaceted systemic effects reflected in blood and ameliorates functional and cognitive outcomes

Roach¹,

Edens²,

Markewych³

et al. 2022

Preprint

View full text Add to dashboard Cite

Introduction. Comprehensive treatment of Alzheimer's disease and related dementias (ADRD) requires not only pharmacologic treatment but also management of existing medical conditions and lifestyle modifications including diet, cognitive training, and exercise. The Coaching for Cognition in Alzheimer's (COCOA) trial was a prospective randomized controlled trial (RCT) to test the hypothesis that a remotely coached multimodal lifestyle intervention would improve early-stage Alzheimer's disease (AD). AD results from the interplay of multiple interacting dysfunctional biological systems. Specific causes of AD differ between individuals. Personalized, multimodal therapies are needed to best prevent and treat AD. COCOA collected psychometric, clinical, lifestyle, genomic, proteomic, metabolomic and microbiome data at multiple timepoints across two years for each participant. These data enable systems-biology analyses. We report analyses of the first COCOA data freeze. This analysis includes an evaluation of the effect of the intervention on outcome measures. It also includes systems analyses to identify molecular mediators that convey the effect of personalized multimodal lifestyle interventions on amelioration of cognitive trajectory. Methods. A total of 55 participants with early-stage AD from Southern California were randomized into two parallel arms. Arm 1 (control; N=24) received standard of care. Arm 2 (intervention; N=31) also received telephonic personalized coaching for multiple lifestyle interventions including diet, exercise, and cognitive training. COCOA's overarching aim was to gather dense molecular data from an AD cohort to improve understanding of pathophysiology and advance treatment. For the RCT, COCOA's objective was to test the hypothesis that the Memory Performance Index (MPI) trajectory would be better in the intervention arm than in the control arm. The Functional Assessment Staging Test (FAST) was assessed for a secondary outcome. Assessments were blinded. The nature of the intervention precluded participant blinding. Results. The intervention arm ameliorated 2.6 ± 0.8 MPI points (p = 0.0007; N = 48) compared to the control arm over the two-year intervention. Top-ranked candidate mediators included: albumin, propionylcarnitine, sphingomyelin, hexadecanedioate, acetylkynurenine, tiglylcarnitine, IL18R1, palmitoyl-sphingosine-phosphoethanolamine, acetyltryptophan, and IL17D. These individual molecules implicated inflammatory and nitrogen/tryptophan metabolism pathways. No important adverse events or side effects were observed. Conclusions. Clinical trials should include frequent assessment of dense data to maximize knowledge gained. Such knowledge is useful not only in testing a primary hypothesis, but also in advancing basic biological and pathophysiological knowledge, understanding mechanisms explaining trial results, generating synergistic knowledge tangential to preconceived hypotheses, and refining interventions for clinical translation. Data from every trial should allow an intervention to be refined and then tested in future trials, driving iterative improvement. Multimodal lifestyle interventions are effective for ameliorating cognitive decline and may have an effect size larger than pharmacological interventions. Effects may be molecularly idiosyncratic; personalization of interventions is important. Dietary changes and exercise are likely to be beneficial components of multimodal interventions in many individuals. Remote coaching is an effective intervention for early stage ADRD. Remote interventions were effective during the COVID pandemic.

show abstract

Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

A multimodal intervention for Alzheimer’s disease results in multifaceted systemic effects reflected in blood and ameliorates functional and cognitive outcomes

Roach¹,

Edens²,

Markewych³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Research has been conducted on the connection between RV consumption and AD in both animal and human systematic reviews. Of these six systematic reviews [ 56 – 61 ], four were systematic reviews involving human subjects [ 56 , 58 , 60 , 61 ], while two involved animal subjects [ 57 , 59 ]. We excluded certain studies from the analysis for various reasons.…”

Section: Methodsmentioning

confidence: 99%

Unraveling the therapeutic efficacy of resveratrol in Alzheimer’s disease: an umbrella review of systematic evidence

Azargoonjahromi,

Abutalebian

2024

Nutr Metab (Lond)

View full text Add to dashboard Cite

Context Resveratrol (RV), a natural compound found in grapes, berries, and peanuts, has been extensively studied for its potential in treating Alzheimer’s disease (AD). RV has shown promise in inhibiting the formation of beta-amyloid plaques (Aβ) and neurofibrillary tangles (NFTs), protecting against neuronal damage and oxidative stress, reducing inflammation, promoting neuroprotection, and improving the function of the blood–brain barrier (BBB). However, conflicting results have been reported, necessitating a comprehensive umbrella review of systematic reviews to provide an unbiased conclusion on the therapeutic effectiveness of RV in AD. Objective The objective of this study was to systematically synthesize and evaluate systematic and meta-analysis reviews investigating the role of RV in AD using data from both human and animal studies. Data sources and extraction Of the 34 systematic and meta-analysis reviews examining the association between RV and AD that were collected, six were included in this study based on specific selection criteria. To identify pertinent studies, a comprehensive search was conducted in English-language peer-reviewed journals without any restrictions on the publication date until October 15, 2023. The search was carried out across multiple databases, including Embase, MEDLINE (PubMed), Cochrane Library, Web of Science, and Google Scholar, utilizing appropriate terms relevant to the specific research field. The AMSTAR-2 and ROBIS tools were also used to evaluate the quality and risk of bias of the included systematic reviews, respectively. Two researchers independently extracted and analyzed the data, resolving any discrepancies through consensus. Of note, the study adhered to the PRIOR checklist. Data analysis This umbrella review presented robust evidence supporting the positive impacts of RV in AD, irrespective of the specific mechanisms involved. It indeed indicated that all six systematic and meta-analysis reviews unanimously concluded that the consumption of RV can be effective in the treatment of AD. Conclusion RV exhibits promising potential for benefiting individuals with AD through various mechanisms. It has been observed to enhance cognitive function, reduce Aβ accumulation, provide neuroprotection, protect the BBB, support mitochondrial function, facilitate synaptic plasticity, stabilize tau proteins, mitigate oxidative stress, and reduce neuroinflammation commonly associated with AD. Graphical abstract

show abstract

“…46 Malnutrition is more common among older adults with cognitive decline, and nutritional problems or lack of appetite may be associated with individuals experiencing neuropsychiatric symptoms of dementia. [47][48][49] Undernutrition was a risk factor for mortality among older adults with dementia in eight LMICs. 50 Fortunately, nutritional interventions have shown positive associations with decreased progression of deterioration in mental function for ADRD.…”

Section: Malnutritionmentioning

confidence: 99%

“…Accessing healthy foods in rural areas is challenging due to limited transportation and high cost 46 . Malnutrition is more common among older adults with cognitive decline, and nutritional problems or lack of appetite may be associated with individuals experiencing neuropsychiatric symptoms of dementia 47–49 . Undernutrition was a risk factor for mortality among older adults with dementia in eight LMICs 50 .…”

Section: Modifiable Factors Contributing To Adrd Burden In Rural Areasmentioning

confidence: 99%

Global rural health disparities in Alzheimer's disease and related dementias: State of the science

Wiese,

Gibson,

Guest

et al. 2023

Alzheimer's & Dementia

View full text Add to dashboard Cite

INTRODUCTIONIndividuals living in rural communities are at heightened risk for Alzheimer's disease and related dementias (ADRD), which parallels other persistent place‐based health disparities. Identifying multiple potentially modifiable risk factors specific to rural areas that contribute to ADRD is an essential first step in understanding the complex interplay between various barriers and facilitators.METHODSAn interdisciplinary, international group of ADRD researchers convened to address the overarching question of: “What can be done to begin minimizing the rural health disparities that contribute uniquely to ADRD?” In this state of the science appraisal, we explore what is known about the biological, behavioral, sociocultural, and environmental influences on ADRD disparities in rural settings.RESULTSA range of individual, interpersonal, and community factors were identified, including strengths of rural residents in facilitating healthy aging lifestyle interventions.DISCUSSIONA location dynamics model and ADRD‐focused future directions are offered for guiding rural practitioners, researchers, and policymakers in mitigating rural disparities.HIGHLIGHTS Rural residents face heightened Alzheimer's disease and related dementia (ADRD) risks and burdens due to health disparities. Defining the unique rural barriers and facilitators to cognitive health yields insight. The strengths and resilience of rural residents can mitigate ADRD‐related challenges. A novel “location dynamics” model guides assessment of rural‐specific ADRD issues.

show abstract

Effect of nutritional supports on malnutrition, cognition, function and biomarkers of Alzheimer’s disease: a systematic review

Cited by 6 publications

References 81 publications

A multimodal intervention for Alzheimer’s disease results in multifaceted systemic effects reflected in blood and ameliorates functional and cognitive outcomes

A multimodal intervention for Alzheimer’s disease results in multifaceted systemic effects reflected in blood and ameliorates functional and cognitive outcomes

Unraveling the therapeutic efficacy of resveratrol in Alzheimer’s disease: an umbrella review of systematic evidence

Global rural health disparities in Alzheimer's disease and related dementias: State of the science

Contact Info

Product

Resources

About