Effect of oat and soybean rich in distinct non-starch polysaccharides on fermentation, appetite regulation and fat accumulation in rat

Tian, Lingmin; Scholte, Jan; Scheurink, Antonius; Berg, Marco van den; Bruggeman, Geert; Bruininx, E.M.A.M.; Vos, Paul de; Schols, Henk A.; Gruppen, Harry

doi:10.1016/j.ijbiomac.2019.08.032

Cited by 30 publications

(15 citation statements)

References 36 publications

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“…Despite recent reports that SBM can reduce the weight of retroperitoneal fat pads, 36 there is limited information on the antiobesity activity of SBM and fermented SBM. In this study, we provide the first evidence for the ameliorating effect of dietary supplementation with SBM fermented by single strain or mixed strains of L. plantarum FPS 2520 and B. subtilis N1 on lipid accumulation and dyslipidemia in HFD-induced obese rats.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antiobesity Activity of Soybean Meal Products Fermented byLactobacillus plantarumFPS 2520 andBacillus subtilisN1 in Rats Fed with High-Fat Diet

Huang

Chen

Chang

et al. 2020

Journal of Medicinal Food

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Single strain or mixed strains of Lactobacillus plantarum FPS 2520 and Bacillus subtilis N1 were used to ferment soybean meal (SBM), and the antiobesity activity of the fermented SBM product was investigated in rats fed with high-fat diet (HFD). After fermentation, free amino nitrogen, total peptide, and isoflavone contents were markedly raised, and genistein and daidzein were the major isoflavones in the fermented SBM. After fed with HFD for 10 weeks, obese Sprague-Dawley rats were orally treated with various fermented products for 6 weeks. The body weight gains, as well as weights of abdominal fat and epididymis fat, of rats fed with fermented SBM products were significantly downregulated. The treatment with the mixed-strains fermented SBM product significantly decreased plasma levels of triglyceride (TG), total cholesterol (TC), and low-density lipoprotein-cholesterol, but increased the level of high-density lipoprotein-cholesterol. Moreover, the levels of TG, TC, fatty acid synthase, and acetyl-CoA carboxylase (ACC) in liver were diminished, and the activities of hormone-sensitive lipase and lipoprotein lipase in adipose tissue were augmented. Taken together, these data demonstrated the antiobesity activity of fermented SBM products, among which the product fermented by the mixed strains being the most effective one. Therefore, these fermented SBM products are potential to be developed as functional foods or additives for treatment of obesity and prevention against obesity-induced complications.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Antiobesity Activity of Soybean Meal Products Fermented byLactobacillus plantarumFPS 2520 andBacillus subtilisN1 in Rats Fed with High-Fat Diet

Huang

Chen

Chang

et al. 2020

Journal of Medicinal Food

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“…We have decided to expose two series of rats, previously fed with maize (cereal) or soy (legume), to accident-provoking protocols. These seeds are of different composition, with in particular different patterns of fermentability 13 , 14 , and they could therefore influence the metabolites distribution in the intestine 15 , 16 {Coward, 1972 #7327}, 17 , 18 . The fecal metabolome of rats was analyzed in order to detect the effect of diet initially, and therefore better spotlight by a statistical process a metabolomic signature which could result from the specific effects of the accident-provoking hyperbaric exposure.…”

Section: Introductionmentioning

confidence: 99%

Cecal metabolome fingerprint in a rat model of decompression sickness with neurological disorders

Maistre¹,

Gaillard²,

Martin³

et al. 2020

Sci Rep

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Massive bubble formation after diving can lead to decompression sickness (DCS), which can result in neurological disorders. We demonstrated that hydrogen production from intestinal fermentation could exacerbate DCS in rats fed with a standard diet. The aim of this study is to identify a fecal metabolomic signature that may result from the effects of a provocative hyperbaric exposure. The fecal metabolome was studied in two groups of rats previously fed with maize or soy in order to account for diet effects. 64 animals, weighing 379.0_20.2 g on the day of the dive, were exposed to the hyperbaric protocol. The rats were separated into two groups: 32 fed with maize (Div MAIZE) and 32 fed with soy (Div SOY). Gut fermentation before the dive was estimated by measuring exhaled hydrogen. Following hyperbaric exposure, we assessed for signs of DCS. Blood was analyzed to assay inflammatory cytokines. Conventional and ChemRICH approaches helped the metabolomic interpretation of the cecal content. The effect of the diet is very marked at the metabolomic level, a little less in the blood tests, without this appearing strictly in the clinic status. Nevertheless, 37 of the 184 metabolites analyzed are linked to clinical status. 35 over-expressed compounds let suggest less intestinal absorption, possibly accompanied by an alteration of the gut microbial community, in DCS. The decrease in another metabolite suggests hepatic impairment. This spectral difference of the ceca metabolomes deserves to be studied in order to check if it corresponds to functional microbial particularities.

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“…Moreover, in vitro fermentation by human fecal microbiota, the acetic acid, propionic acid, and lactic acid contents of batch cultures with okara were higher than those with fructo‐oligosaccharides (Pérez‐López, Cela, Costabile, Mateos‐Aparicio, & Rupérez, 2016). In vivo , the SCFAs concentration in the cecal digesta of rats fed soybean meal enriched diet were 1.4 folds higher than those in rats fed oats enriched diet (Tian et al., 2019). A meta‐analysis reported that the fecal levels of propionic acid and butyric acid in patients with irritable bowel syndrome (IBS)‐constipation were reduced than those in healthy controls (Sun, Jia, Song, & Duan, 2019).…”

Section: Resultsmentioning

confidence: 99%

Intake of okara soup for 2 weeks for breakfast improved defecation habits in young Japanese women with self‐reported constipation: A randomized, double‐blind, placebo‐controlled, intervention study

Maeta

Katsukawa

Inomoto

et al. 2020

Journal of Food Science

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Okara is a byproduct of soymilk manufacturing and a rich source of protein and dietary fiber. We investigated whether okara intake improves the habit of defecation in young Japanese women (n = 52) with self-reported constipation. Subjects were categorized into placebo and test groups, who ingested soymilk (0.1 g fiber/meal) and okara (4.1 g fiber/meal) soups, respectively, every day for breakfast, for 2 weeks. Subjects' body composition, bowel movement frequency per week, and constipation assessment scale (CAS) and brief-type self-administered diet history questionnaire scores were assessed at baseline and after the intervention (Analysis 1). Further, subjects' bowel movement frequency per week and CAS scores were assessed during the 2-week follow-up (Analysis 2). There were no significant differences in age, anthropometric characteristics, nutrients intake, frequency of bowel movements per week, and total CAS scores between the placebo and test groups at baseline. After intervention, the total CAS score was significantly lower in the test group than in the placebo group. Moreover, the difference in the total CAS scores between baseline and after intervention was lower in the test group than in the placebo group, although not significant. The weekly frequency of bowel movement significantly increased for both placebo and test groups. The test group reported reduced abdominal bloating 2 weeks after the intervention, but the placebo group did not. The findings suggest that okara is effective in increasing the frequency of bowel movements and improving defecation habit in young women with self-reported constipation.

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Effect of oat and soybean rich in distinct non-starch polysaccharides on fermentation, appetite regulation and fat accumulation in rat

Cited by 30 publications

References 36 publications

Evaluation of Antiobesity Activity of Soybean Meal Products Fermented byLactobacillus plantarumFPS 2520 andBacillus subtilisN1 in Rats Fed with High-Fat Diet

Evaluation of Antiobesity Activity of Soybean Meal Products Fermented byLactobacillus plantarumFPS 2520 andBacillus subtilisN1 in Rats Fed with High-Fat Diet

Cecal metabolome fingerprint in a rat model of decompression sickness with neurological disorders

Intake of okara soup for 2 weeks for breakfast improved defecation habits in young Japanese women with self‐reported constipation: A randomized, double‐blind, placebo‐controlled, intervention study

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