Effect of obesity and diabetes mellitus type 2 on vascular stiffness

Abstract

OBJECTIVES METHODS CONCLUSIONSTo investigate the impact of overall obesity (Ob) and diabetes mellitus type 2 (DM2) on arterial stiffness and degree of insulin resistance in patients with arterial hypertension (AH) and abdominal obesity (AOb).74 subjects were divided according to presence of AH, AOb, Ob and DM2 without insulin therapy. Control group 1 consisted of 26 subjects without AH, AOb, Ob and DM2. All patients with AH were also diagnosed with AOb and amounted to 48 subjects. Then patients with AH and AOb were divided into two groups (group 2 and 3 respectively) according to presence of Ob, defined by BMI and furthermore, DM2. Carotid-femoral pulse wave velocity (PWVcf) measurements were performed using SphygmoCor. Homeostasis model assessment-insulin resistance (HOMA-IR) was calculated by the following formula: fasting plasma insulin (mU/ml) x fasting plasma glucose (mmol/l)/22.5.