Effect of observation of simple hand movement on brain activations in patients with unilateral cerebral palsy: an fMRI study

Dinomais, Mickaël; Lignon, G.; Chinier, Eva; Rodet-Belarbi, Isabelle; Minassian, Aram Ter; Tich, Sylvie Nguyen The

doi:10.1016/j.ridd.2013.03.020

Cited by 30 publications

(32 citation statements)

References 36 publications

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“…Subjects 1 to 18 were recruited as part of our previous work investigating the action-observation network in patients with CP [16], [17]. Subjects 19 and 20 with clinical apparent left unilateral CP were added in this study.…”

Section: Methodsmentioning

confidence: 99%

Effect of Motor Imagery in Children with Unilateral Cerebral Palsy: fMRI Study

et al. 2014

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BackgroundMotor imagery is considered as a promising therapeutic tool for rehabilitation of motor planning problems in patients with cerebral palsy. However motor planning problems may lead to poor motor imagery ability.AimThe aim of this functional magnetic resonance imaging study was to examine and compare brain activation following motor imagery tasks in patients with hemiplegic cerebral palsy with left or right early brain lesions. We tested also the influence of the side of imagined hand movement.MethodTwenty patients with clinical hemiplegic cerebral palsy (sixteen males, mean age 12 years and 10 months, aged 6 years 10 months to 20 years 10 months) participated in this study. Using block design, brain activations following motor imagery of a simple opening-closing hand movement performed by either the paretic or nonparetic hand was examined.ResultsDuring motor imagery tasks, patients with early right brain damages activated bilateral fronto-parietal network that comprise most of the nodes of the network well described in healthy subjects. Inversely, in patients with left early brain lesion brain activation following motor imagery tasks was reduced, compared to patients with right brain lesions. We found also a weak influence of the side of imagined hand movement.ConclusionDecreased activations following motor imagery in patients with right unilateral cerebral palsy highlight the dominance of the left hemisphere during motor imagery tasks. This study gives neuronal substrate to propose motor imagery tasks in unilateral cerebral palsy rehabilitation at least for patients with right brain lesions.

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Section: Methodsmentioning

confidence: 99%

Effect of Motor Imagery in Children with Unilateral Cerebral Palsy: fMRI Study

et al. 2014

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“…While there is no cure for the brain lesion in CP, the manifestations of this condition can be minimized through neurorehabilitation [14]. Studies involving the administration of functional magnetic resonance on children with CP have demonstrated that rehabilitation resources are capable of promoting the activation of the primary motor cortex (M1) [14].…”

Section: Introductionmentioning

confidence: 99%

“…Studies involving the administration of functional magnetic resonance on children with CP have demonstrated that rehabilitation resources are capable of promoting the activation of the primary motor cortex (M1) [14]. M1 is an important area of the brain that facilitates cerebral reorganization.…”

Section: Introductionmentioning

confidence: 99%

Effect of Transcranial Direct-Current Stimulation Combined with Treadmill Training on Balance and Functional Performance in Children with Cerebral Palsy: A Double-Blind Randomized Controlled Trial

et al. 2014

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BackgroundCerebral palsy refers to permanent, mutable motor development disorders stemming from a primary brain lesion, causing secondary musculoskeletal problems and limitations in activities of daily living. The aim of the present study was to determine the effects of gait training combined with transcranial direct-current stimulation over the primary motor cortex on balance and functional performance in children with cerebral palsy.MethodsA double-blind randomized controlled study was carried out with 24 children aged five to 12 years with cerebral palsy randomly allocated to two intervention groups (blocks of six and stratified based on GMFCS level (levels I-II or level III).The experimental group (12 children) was submitted to treadmill training and anodal stimulation of the primary motor cortex. The control group (12 children) was submitted to treadmill training and placebo transcranial direct-current stimulation. Training was performed in five weekly sessions for 2 weeks. Evaluations consisted of stabilometric analysis as well as the administration of the Pediatric Balance Scale and Pediatric Evaluation of Disability Inventory one week before the intervention, one week after the completion of the intervention and one month after the completion of the intervention. All patients and two examiners were blinded to the allocation of the children to the different groups.ResultsThe experimental group exhibited better results in comparison to the control group with regard to anteroposterior sway (eyes open and closed; p<0.05), mediolateral sway (eyes closed; p<0.05) and the Pediatric Balance Scale both one week and one month after the completion of the protocol.ConclusionGait training on a treadmill combined with anodal stimulation of the primary motor cortex led to improvements in static balance and functional performance in children with cerebral palsy.Trial RegistrationEnsaiosclinicos.gov.br/RBR-9B5DH7

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“…The reduction in somatosensory activation may be the neurological basis for poor tactile, proprioceptive and kinesthetic awareness in children with CP8. While there is no cure for the brain lesion associated with this condition, sequelae can be minimized through neurorehabilitation methods9. Studies involving functional magnetic resonance in children with CP have demonstrated that rehabilitation resources are capable of promoting the activation of the primary motor cortex9, which is an important area of the brain capable of facilitating cerebral reorganization10.…”

Section: Introductionmentioning

confidence: 99%

Effect of a single session of transcranial direct-current stimulation on balance and spatiotemporal gait variables in children with cerebral palsy: A randomized sham-controlled study

Grecco¹,

Duarte²,

Zanon³

et al. 2014

Braz. J. Phys. Ther.

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Background: Transcranial direct-current stimulation (tDCS) has been widely studied with the aim of enhancing local synaptic efficacy and modulating the electrical activity of the cortex in patients with neurological disorders. Objective: The purpose of the present study was to determine the effect of a single session of tDCS regarding immediate changes in spatiotemporal gait and oscillations of the center of pressure (30 seconds) in children with cerebral palsy (CP). Method:A randomized controlled trial with a blinded evaluator was conducted involving 20 children with CP between six and ten years of age. Gait and balance were evaluated three times: Evaluation 1 (before the stimulation), Evaluation 2 (immediately after stimulation), and Evaluation 3 (20 minutes after the stimulation). The protocol consisted of a 20-minute session of tDCS applied to the primary motor cortex at an intensity of 1 mA. The participants were randomly allocated to two groups: experimental group - anodal stimulation of the primary motor cortex; and control group - placebo transcranial stimulation. Results: Significant reductions were found in the experimental group regarding oscillations during standing in the anteroposterior and mediolateral directions with eyes open and eyes closed in comparison with the control group (p<0.05). In the intra-group analysis, the experimental group exhibited significant improvements in gait velocity, cadence, and oscillation in the center of pressure during standing (p<0.05). No significant differences were found in the control group among the different evaluations. Conclusion: A single session of tDCS applied to the primary motor cortex promotes positive changes in static balance and gait velocity in children with cerebral palsy.

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Effect of observation of simple hand movement on brain activations in patients with unilateral cerebral palsy: an fMRI study

Cited by 30 publications

References 36 publications

Effect of Motor Imagery in Children with Unilateral Cerebral Palsy: fMRI Study

Effect of Motor Imagery in Children with Unilateral Cerebral Palsy: fMRI Study

Effect of Transcranial Direct-Current Stimulation Combined with Treadmill Training on Balance and Functional Performance in Children with Cerebral Palsy: A Double-Blind Randomized Controlled Trial

Effect of a single session of transcranial direct-current stimulation on balance and spatiotemporal gait variables in children with cerebral palsy: A randomized sham-controlled study

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