Effect of occupational exposure to lead on new risk factors for cardiovascular diseases

Prokopowicz, Adam; Sobczak, Andrzej; Szuła-Chraplewska, Magdalena; Zaciera, Marzena; Kurek, Jolanta; Szołtysek-Bołdys, Izabela

doi:10.1136/oemed-2016-103996

Cited by 29 publications

(23 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Apoptosis of endothelium cells, which cannot be cleared away from vessels immediately, would cause gradual accumulation of foam cells [27]. In a study by Tanaka et al [28]. , FGF-2 treatment increased the number of vasa vasorum and accumulation of Mac3-positive macrophages in atherosclerotic lesion formation, which is consistent with our results.…”

Section: Discussionsupporting

confidence: 82%

Knockout of Low Molecular Weight FGF2 Attenuates Atherosclerosis by Reducing Macrophage Infiltration and Oxidative Stress in Mice

Liang

Wang

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Fibroblast growth factor 2 (FGF2) plays a predominant role during angiogenesis in the adventitia and in atherosclerotic plaque. A dilemma exists, however, as to whether angiogenic stimulation by FGF2 for the prevention and treatment of atherogenesis is feasible. The aim of this study is to investigate the effect of the 18-kDa FGF-2 isoform on atherosclerosis progression in high-fat diet-fed apolipoprotein E knockout (ApoE-/-) mice. Methods: We established a model of atherosclerosis using ApoE and 18-kDa FGF-2 gene double knockout mice. They were randomly divided into three groups depending on the duration of diet: 8 weeks, 12 weeks and 16 weeks. Then, we studied the morphology and inflammatory factor staining in the atherosclerosis plaque of these mice. Results: Knockout of the 18-kDa FGF-2 isoform did not change the metabolic characteristics of the mice. Compared to the control group, knockout of the 18-kDa FGF-2 isoform significantly attenuated atherogenesis, reduced aortic plaques, reduced macrophage infiltration and suppressed oxidative stress in mice fed with a high fat diet at all-time points. Conclusions: 18-kDa FGF-2 aggravated the inflammatory reaction of atherosclerosis.

show abstract

Section: Discussionsupporting

confidence: 82%

Knockout of Low Molecular Weight FGF2 Attenuates Atherosclerosis by Reducing Macrophage Infiltration and Oxidative Stress in Mice

Liang

Wang

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

show abstract

“…Additionally, Prokopowicz et al . revealed that, with 231 male adults, non-occupational exposure to lead was correlated with new risk factors for CVD, in detail L-homoarginine, fibrinogen, C-reactive protein and homocysteine 14 . For CVRF, Peters et al .…”

Section: Discussionmentioning

confidence: 99%

Associations between lead concentrations and cardiovascular risk factors in U.S. adolescents

Shu

Zhi

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Little is known regarding the effects of environmental lead exposure on cardiovascular risk factors in the adolescent population. We studied 11,662 subjects included in the National Health and Nutrition Examination Survey (NHANES) 1999–2012. Blood lead levels were analysed for their association with cardiovascular risk factors (CVRF). Regression coefficients (Beta) and 95% confidence intervals (CIs) of blood lead in association with CVRF (e.g., total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride, fasting glucose, glycohemoglobin, fasting insulin, and blood pressure) were estimated using multivariate and generalized linear regression after adjusting for age, gender, ethnicity, serum cotinine, body mass index (BMI), physical activity, and household income. We identified a strong positive association between blood lead (coefficient = 0.022, 95% CI 0.003, 0.041; P = 0.022) and LDL-cholesterol in adolescents (age 12–19 years). However, no associations with other CVRFs were found in the overall population. In the generalized linear models, participants with the highest lead levels demonstrated a 1.87% (95% CI 0.73%, 3.02%) greater increase in serum LDL-cholesterol (p for trend = 0.031) when compared to participants with the lowest lead levels. These results provide epidemiological evidence that low levels of blood lead are positively associated with LDL-cholesterol in the adolescent population.

show abstract

“…Это свидетельствует о воспалительном действии свинца, которое может привести к развитию атеросклероза у молодых людей даже при отсутствии клинических признаков и симптомов интоксикации [29]. Prokopowicz A, et al (2017) изучали воздействие свинца на рабочих, чья деятельность была связана с добычей и переработкой свинца. Авторами выявлена связь между свинцом в крови и биомаркерами ССЗ, такими как L-гомоаргинин, фибриноген, С-реактивный белок и гомоцистеин.…”

unclassified

“…Авторами выявлена связь между свинцом в крови и биомаркерами ССЗ, такими как L-гомоаргинин, фибриноген, С-реактивный белок и гомоцистеин. Профессиональное воздействие свинца может способствовать развитию атеросклероза, особенно, у людей с высокой степенью воздействия [30].…”

unclassified

The role of dietary minerals in the development of atheroma

Polonskaya

Kashtanova

2019

Russ J Cardiol

View full text Add to dashboard Cite

В статье представлен обзор зарубежных и отечественных исследований, направленных на изучение роли элементного дисбаланса в развитии сердечно-сосудистой патологии. Обсуждаются патогенетически значимые механизмы влияния дисэлементозов на развитие атеросклеротических изменений в стенках сосудов. Особое внимание уделено таким элементам, как железо, медь, цинк, селен, кадмий.

show abstract

Effect of occupational exposure to lead on new risk factors for cardiovascular diseases

Abstract: These findings support the hypothesis that occupational exposure to lead can promote atherosclerosis, particularly in highly exposed individuals.

Cited by 29 publications

References 34 publications

Knockout of Low Molecular Weight FGF2 Attenuates Atherosclerosis by Reducing Macrophage Infiltration and Oxidative Stress in Mice

Knockout of Low Molecular Weight FGF2 Attenuates Atherosclerosis by Reducing Macrophage Infiltration and Oxidative Stress in Mice

Associations between lead concentrations and cardiovascular risk factors in U.S. adolescents

The role of dietary minerals in the development of atheroma

Contact Info

Product

Resources

About