Effect of occupational physical activities on vertebral dimensions in midlife in the Northern Finland Birth Cohort 1966

Oura, Petteri; Paananen, Markus; Niinimäki, Jaakko; Auvinen, Juha; Ala‐Mursula, Leena; Junno, Juho‐Antti; Karppinen, Jaro

doi:10.1136/oemed-2016-104025

Cited by 14 publications

(18 citation statements)

References 34 publications

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“…The axial CSA of L4 (mm 2 ) was calculated using the previously validated (2,15) ellipsoid formula CSA = π x a/2 x b/2, in which a = vertebral width (mean of measured widths) and b = vertebral depth (mean of measured depths). We chose to investigate this parameter because 1) it substantially affects the weightbearing capacity of the vertebra (5,16), 2) it is independently associated with vertebral fracture risk (1,3,17), and 3) it has been previously used in similar studies (8,(18)(19)(20)(21)(22)(23).…”

Section: Vertebral Measurementsmentioning

confidence: 99%

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Changes in vertebral dimensions in early adulthood – A 10-year follow-up MRI-study

Autio

Oura

Karppinen

et al. 2019

Bone

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Previous studies have shown that vertebral height increases until the early twenties, but very few studies have been conducted on other vertebral dimensions. Growth in vertebral size is believed to take place in elderly age but not in early adulthood. In this study, we wanted to clarify the potential changes in the dimensions of the lumbar vertebrae during early adulthood. We used the Northern Finland Birth Cohort 1986 as our study material, with a final sample size of 375 individuals. We performed lumbar magnetic resonance imaging (MRI) when the participants were 20 and 30 years of age (baseline and follow-up, respectively). We recorded the width, depth, height, and cross-sectional area (CSA) of the fourth lumbar vertebra (L4) using the MRI scans. We used generalized estimating equation (GEE) models to analyse the data. Men had 7.6%-26.5% larger vertebral dimensions than women at both baseline and follow-up. The GEE models demonstrated that all the studied dimensions increased during the follow-up period among both sexes (p < 0.001). Men had a higher growth rate in vertebral depth and CSA than women (p < 0.001). Among women, small vertebral width (p = 0.001), depth (p = 0.05) and height (p = 0.02) at baseline were associated with a higher vertebral growth rate during the follow-up than among those with large dimensions at baseline. Among men, small baseline width was associated with higher vertebral growth rate (p = 0.001). Our results clearly indicate that vertebral dimensions increase after 20 years of age among both sexes.

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Section: Vertebral Measurementsmentioning

confidence: 99%

“…We chose L4 because 1) its caudal location in the spine exposes it to significant biomechanical loads (24), 2) it is more stable than L5 (24), 3) it seems to represent the other lumbar vertebrae well (21,25), and 4) it has been previously used in similar studies (8,(18)(19)(20)(21)(22)(23)26).…”

Section: Vertebral Measurementsmentioning

confidence: 99%

Changes in vertebral dimensions in early adulthood – A 10-year follow-up MRI-study

Autio

Oura

Karppinen

et al. 2019

Bone

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“…We measured L4 as it was located in the centre of the MRI scans and was therefore most often accessible with appropriate axial and sagittal slices. L4 is known to represent the other lumbar vertebrae well [28,29] and has been used in a number of previous studies [28,[30][31][32][33]. We have previously used cadaveric vertebrae to compare MRI-based vertebral measurements to direct measurements taken with standard osteometric calipers and concluded that they are highly equivalent (correlation coefficient = 0.985) [15].…”

Section: Vertebral Measurementsmentioning

confidence: 99%

“…Here, we report the sex estimation potential of three easily obtainable dimensions of the L4 body (width, depth, height) in three age groups (20,30,46 years) of the general living Northern Finnish population. We obtained the L4 dimensions from recent lumbar magnetic resonance imaging (MRI) scans, and used univariate and multivariate logistic regression models to assess them in terms of sex estimation.…”

Section: Introductionmentioning

confidence: 99%

Sex estimation from dimensions of the fourth lumbar vertebra in Northern Finns of 20, 30, and 46 years of age

Oura

Karppinen

Niinimäki

et al. 2018

Forensic Science International

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“…CSA was chosen because of its direct association with vertebral weight‐bearing capacity and fracture risk . The CSA of L 4 has also been a common outcome in similar studies . We have previously shown that vertebral dimensions can be accurately measured using MRI .…”

Section: Methodsmentioning

confidence: 99%

Body Mass Index Trajectories From Birth to Midlife and Vertebral Dimensions in Midlife: the Northern Finland Birth Cohort 1966 Study

et al. 2018

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Vertebral fracture risk is higher among individuals with small vertebral dimensions. Obesity is a global health problem and may also contribute to bone size and fracture risk. In this work we report the association between life course body mass index (BMI) and vertebral cross-sectional area (CSA) in midlife. The Northern Finland Birth Cohort 1966 study with its 46-year follow-up provided the material for this study. A subsample of 780 individuals had attended lumbar magnetic resonance imaging (MRI) at the age of 46 years, and had records of objectively measured BMI from the ages of 0, 7, 15, 31, and 46 years. Of these, MRI-derived data on vertebral size was available for 682 individuals. We identified latent lifelong BMI trajectories by performing latent class growth modeling (LCGM) on the BMI data, and then used sex-stratified linear regression models to compare the identified trajectory groups in terms of midlife vertebral CSA. Gestational age, education years, adult height, lifelong physical activity, lifelong smoking history, and adulthood diet were assessed as potential confounders. Three distinct trajectory groups ("stable slim," "stable average," and "early onset overweight") were identified among both sexes. Comparisons to the stable slim trajectory revealed that vertebral CSA was significantly (p < 0.001) larger among the stable average and early onset overweight trajectories (69.8 and 118.6 mm 2 larger among men, 57.7 and 106.1 mm 2 larger among women, respectively). We conclude that lifelong BMI has a positive association with midlife vertebral size among both sexes. Future studies should characterize the mediating factors of this association.

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Effect of occupational physical activities on vertebral dimensions in midlife in the Northern Finland Birth Cohort 1966

Abstract: OPA seems to have very little effect on vertebral size. Our results suggest that the effect of LTPA on vertebral size is different to that of OPA.

Cited by 14 publications

References 34 publications

Changes in vertebral dimensions in early adulthood – A 10-year follow-up MRI-study

Changes in vertebral dimensions in early adulthood – A 10-year follow-up MRI-study

Sex estimation from dimensions of the fourth lumbar vertebra in Northern Finns of 20, 30, and 46 years of age

Body Mass Index Trajectories From Birth to Midlife and Vertebral Dimensions in Midlife: the Northern Finland Birth Cohort 1966 Study

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