Effect of oestrone on the renal response to posterior pituitary extract in rats

Effect of vasopressin administration on renal haemodynamic changes in rats treated with ACTH

“…Our results indicated t h a t renal cortical necrosis also occurs in adrenalectomized rats p r e t r e a t e d with oestrogen after a d m i n i s t r a t i o n of a posterior p i t u i t a r y e x t r a c t [23]. W h e n A C T H was administered in place of oestrone p r e t r e a t m e n t , however, extensive renal cortical necrosis of hypoxic origin resulted following the administration of a vasopressin-containing extract [17,21]. I t was found t h a t in h y p o p h y s e e t o m i z e d animals the changes were s u b s t a n t i a l l y less [22].…”

“…Since the vasopressin caused a considerable temporary decrease of the renal blood flow in rats pretreated with oestrogen [18], it was considered of value to make a study of the renal haemodynamic conditions in animals treated with ACTH + vasopressin. The present paper reports the results of these experiments.…”