Effect of oil palm phenolics on gastrointestinal transit, contractility and motility in the rat

Patten, Glen S.; Abeywardena, Mahinda Y.; Sundram, Kalyana; Tan, Yew Ai; Sambanthamurthi, Ravigadevi

doi:10.1016/j.jff.2015.06.008

Cited by 9 publications

(7 citation statements)

References 53 publications

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“…Additionally, genes involved in cholesterol biosynthesis were down-regulated, suggesting a possible role in preventing hypercholesterolemia 12 . OPP also attenuated atherosclerosis 13 , 14 as well as responded positively towards the distal colonic contractility and motility 15 in animal models.…”

Section: Introductionmentioning

confidence: 80%

A phase I single-blind clinical trial to evaluate the safety of oil palm phenolics (OPP) supplementation in healthy volunteers

Fairus

Leow

Mohamed

et al. 2018

Sci Rep

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Plant phenolics are being increasingly consumed globally with limited scientific and clinical evidence pertaining to safety and efficacy. The oil palm fruit contains a cocktail of phenolics, and palm oil production results in high volumes of aqueous by-products enriched in phenolics and bioactives. Several lines of evidence from in vitro and in vivo animal studies confirmed that the aqueous extract enriched in phenolics and other bioactives collectively known as oil palm phenolics (OPP) is safe and has potent bioactivity. A phase one clinical trial was conducted to evaluate the safety and effects of OPP in healthy volunteers. In this single-blind trial, 25 healthy human volunteers were supplemented with 450 mg gallic acid equivalent (GAE)/day of OPP or control treatments for a 60-day period. Fasting blood and urine samples were collected at days 1, 30 and 60. Medical examination was performed during these trial interventions. All clinical biochemistry profiles observed throughout the control and OPP treatment period were in the normal range with no major adverse effect (AE) or serious adverse effect (SAE) observed. Additionally, OPP supplementation resulted in improvement of total cholesterol and LDL-C levels, compared to the control treatment. The outcomes support our previous observations that OPP is safe and may have a protective role in reducing cholesterol levels.

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Section: Introductionmentioning

confidence: 80%

A phase I single-blind clinical trial to evaluate the safety of oil palm phenolics (OPP) supplementation in healthy volunteers

Fairus

Leow

Mohamed

et al. 2018

Sci Rep

Self Cite

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“…Rapid development of palm oil industries and the increase of the palm oil demand leads to increase of the by-product and bio-wastes generated which includes empty fruit bunches (EFB), palm oil mill effluent (POME), sterilizer condensate, palm fiber and palm kernel shell 4. A huge amount of bio-waste would give rise to the negative impact to the environment 5. In the oil palm industry, large amount of vegetation liquor are discarded into the aqueous waste stream during the palm oil milling process, amounting to 90 million tons per year globally 5, 6.…”

Section: Introductionmentioning

confidence: 99%

“…A huge amount of bio-waste would give rise to the negative impact to the environment 5. In the oil palm industry, large amount of vegetation liquor are discarded into the aqueous waste stream during the palm oil milling process, amounting to 90 million tons per year globally 5, 6. A novel process to recover phenolic compounds from the aqueous waste stream were developed and resulting in producing a filtrate known as oil palm phenolics (OPP), containing high amount of phenolics 6-11.…”

Section: Introductionmentioning

confidence: 99%

The Pharmacological Potential of Oil Palm Phenolics (OPP) Individual Components

Syarifah-Noratiqah¹,

Zulfarina²,

Ahmad³

et al. 2019

Int. J. Med. Sci.

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The oil palm tree ( Elaeis guineensis ) from the family Arecaceae is a high oil-producing agricultural crop. A significant amount of vegetation liquor is discarded during the palm oil milling process amounting to 90 million tons per year around the world. This water-soluble extract is rich in phenolic compounds known as Oil Palm Phenolics (OPP). Several phenolic acids including the three isomers of caffeoylshikimic acid (CFA), p -hydroxybenzoic acid (PHBA), protocatechuic acid (PCA) and hydroxytyrosol are among the primary active ingredients in the OPP. Previous investigations have reported several positive pharmacological potentials by OPP such as neuroprotective and atheroprotective effects, anti-tumor and reduction in Aβ deposition in Alzheimer's disease model. In the current review, the pharmacological potential for CFA, PHBA, PCA and hydroxytyrosol is carefully reviewed and evaluated.

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“…However, there have been a few reports that angiotensin II can elicit direct effects on gut smooth muscle as well as indirect effects via myenteric plexus cholinergic neurons ( Spak et al, 2008 ; Mastropaolo et al, 2015 ). For the gut, it has been demonstrated that angiotensin II acts mainly at the angiotensin type 1 (AT 1 ) receptor ( Sechi et al, 1993 ) in rodents and humans and has been shown to be antagonized by losartan and its analogs, termed angiotensin receptor blockers (ARBs) ( Dickstein et al, 1998 ; Garg et al, 2012 ; Mastropaolo et al, 2013 , 2015 ; Patten et al, 2015a ). Many drugs can cause pathology and dysmotility of the small and large intestine ( Geboes et al, 2006 ; Zeino et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

“…Separate no-treatment SHRs were used as controls. To do this, we examined the effects of these antihypertensive agents on the ex vivo induced contractility of intact sections of ileum and colon by KCl; electrical stimulation; and muscarinic, prostanoid, and angiotensin receptor–dependent agonists ( Patten et al, 2004 , 2005 , 2015a , b ). We hypothesize that antihypertensive drugs may affect intestinal contractility and motility.…”

Section: Introductionmentioning

confidence: 99%

Effects of Antihypertensive Agents on Intestinal Contractility in the Spontaneously Hypertensive Rat: Angiotensin Receptor System Downregulation by Losartan

Patten

Abeywardena

2016

J Pharmacol Exp Ther

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Hypertension is an inflammatory condition controlled by the renin angiotensin system and is linked to kidney disease, diabetes mellitus, and recently to dysfunction of the gut. The aim of this study was to determine what effect antihypertensive drug treatments may have on intestinal function of the spontaneously hypertensive rat (SHR). In the first experiment, SHRs were treated with enalapril, hydralazine, or with no treatment as a control. In the second experiment, SHRs were treated with losartan or with no treatment as a control. All drug treatments led to significant lowering of blood pressure after 16 weeks. At termination, intact tissue sections of the ileum and colon were induced to contract ex vivo by KCl; electrical stimulation; and agonists carbachol, angiotensin II, and prostaglandin E2 (PGE2). There were no differences in ileal or colonic contractility due to hydralazine or enalapril compared with no-treatment SHR control. However, for the ileum, the losartan group responded significantly more to KCl and carbachol while responding less to angiotensin II, with no difference for PGE2 compared with the no-treatment SHR control. In contrast, the colon responded similarly to KCl, electrical stimulation, and PGE2 but responded significantly less to angiotensin II. These results demonstrate that the ileum responds differently (with KCl and carbachol as agonists) to the colon after losartan treatment, whereas there is a reduced contractile response in both the ileum and colon following losartan treatment. Although there are few well documented major contraindications for angiotensin receptor blockers, the modulation of gut contractility by losartan may have wider implications for bowel health.

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Effect of oil palm phenolics on gastrointestinal transit, contractility and motility in the rat

Cited by 9 publications

References 53 publications

A phase I single-blind clinical trial to evaluate the safety of oil palm phenolics (OPP) supplementation in healthy volunteers

A phase I single-blind clinical trial to evaluate the safety of oil palm phenolics (OPP) supplementation in healthy volunteers

The Pharmacological Potential of Oil Palm Phenolics (OPP) Individual Components

Effects of Antihypertensive Agents on Intestinal Contractility in the Spontaneously Hypertensive Rat: Angiotensin Receptor System Downregulation by Losartan

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