Effect of oleuropein on morphine-induced hippocampus neurotoxicity and memory impairments in rats

Shibani, Farhad; Sahamsizadeh, Ali; Fatemi, Iman; Allahtavakoli, Mohammad; Hasanshahi, Jalal; Rahmani, Amir M.; Azin, Mahdieh; Hassanipour, Mahsa; Mozafari, Nazanin; Kaeidi, Ayat

doi:10.1007/s00210-019-01678-3

Cited by 26 publications

(11 citation statements)

References 54 publications

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“…Additionally, several data indicate that OLE interferes with APP processing [129] and with the amyloid aggregation of Aβ and tau protein, escaping the growth of toxic Aβ oligomers both in vitro [17,19,130,131], in C. elegans [132], and in TgCRND8 mice, a transgenic model of Aβ deposition [40]. In accordance with these data, a recent study has reported that rats fed with OLE display significant improvement of cognitive performance; in fact, OLE diet decreases the apoptosis and oxidative stress levels and prevents the impairment of spatial learning and memory resulting from morphine-induced neurotoxicity to the hippocampus [133].…”

Section: Redox Homeostasis and The Inflammatory Responsementioning

confidence: 72%

Healthy Effects of Plant Polyphenols: Molecular Mechanisms

Leri

Scuto

Ontario

et al. 2020

IJMS

331

213

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The increasing extension in life expectancy of human beings in developed countries is accompanied by a progressively greater rate of degenerative diseases associated with lifestyle and aging, most of which are still waiting for effective, not merely symptomatic, therapies. Accordingly, at present, the recommendations aimed at reducing the prevalence of these conditions in the population are limited to a safer lifestyle including physical/mental exercise, a reduced caloric intake, and a proper diet in a convivial environment. The claimed health benefits of the Mediterranean and Asian diets have been confirmed in many clinical trials and epidemiological surveys. These diets are characterized by several features, including low meat consumption, the intake of oils instead of fats as lipid sources, moderate amounts of red wine, and significant amounts of fresh fruit and vegetables. In particular, the latter have attracted popular and scientific attention for their content, though in reduced amounts, of a number of molecules increasingly investigated for their healthy properties. Among the latter, plant polyphenols have raised remarkable interest in the scientific community; in fact, several clinical trials have confirmed that many health benefits of the Mediterranean/Asian diets can be traced back to the presence of significant amounts of these molecules, even though, in some cases, contradictory results have been reported, which highlights the need for further investigation. In light of the results of these trials, recent research has sought to provide information on the biochemical, molecular, epigenetic, and cell biology modifications by plant polyphenols in cell, organismal, animal, and human models of cancer, metabolic, and neurodegenerative pathologies, notably Alzheimer’s and Parkinson disease. The findings reported in the last decade are starting to help to decipher the complex relations between plant polyphenols and cell homeostatic systems including metabolic and redox equilibrium, proteostasis, and the inflammatory response, establishing an increasingly solid molecular basis for the healthy effects of these molecules. Taken together, the data currently available, though still incomplete, are providing a rationale for the possible use of natural polyphenols, or their molecular scaffolds, as nutraceuticals to contrast aging and to combat many associated pathologies.

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Section: Redox Homeostasis and The Inflammatory Responsementioning

confidence: 72%

Healthy Effects of Plant Polyphenols: Molecular Mechanisms

Leri

Scuto

Ontario

et al. 2020

IJMS

331

213

View full text Add to dashboard Cite

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“…They observed that treatment with OL (15 & 30 mg/kg BW) improved the antioxidant's activity, that is, SOD and GPx, memory deficits and spatial learning in neurotoxic rats. OL also reduced the lipid peroxidation and apoptosis in brain cells by regulating the expression of Bcl2/Bax proteins (Shibani et al., 2019). OL exerts neuroprotective role by enhancing the protein kinase A mediated phosphorylation, surface expression of GluA1 and hence, enhances the intracellular calcium influx in mice hippocampal slices thus exerts beneficial effects in tackling the age‐related memory impairments (Wang et al., 2020).…”

Section: Neuroprotective Role Of Oleuropeinmentioning

confidence: 99%

Neuroprotective effects of oleuropein: Recent developments and contemporary research

et al. 2021

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Neurological disorders are increasing at a faster pace due to oxidative stress, protein aggregation, excitotoxicity, and neuroinflammation. It is reported that the Mediterranean diet including olives as a major dietary component prevents and ameliorates neurological anomalies. Oleuropein is the major bioactive component in different parts of the Olive (Olea europaea L.) tree. Several mechanisms have been reported for the neuroprotective role of oleuropein including induction of apoptosis and autophagy, enhancing the antioxidant pool of the cerebral region, decreasing the unnecessary release of proinflammatory cytokines and chemokines by deactivating the microglia cells and astrocytes thus preventing the occurrence of neuroinflammation. Regular intake of oleuropein seems to be correlated with decreased risks of neural disorders including Alzheimer's, Parkinson's, strokes, depression, anxiety, epilepsy, and others. This review majorly discusses the chemistry, biosynthesis, and metabolism of oleuropein along with an updated vision of its neuroprotective role in counteracting the acute and chronic neurodegenerative and neuropsychiatric disorders. Moreover, mechanisms by which oleuropein may prevent neurodegeneration are reviewed. Practical application Neurological disorders are negatively affecting the health and life quality of individuals around the globe. Although various medicinal solutions are available to tackle such ailments, none has proven to fully cure and being deprived of side effects. In this respect, the prevention of such disorders using natural remedies may be an effective strategy to overcome the incidence of the increasing cases. Furthermore, the natural compounds provide a safer alternative to pharmaceutical drugs. Hence, oleuropein from olive tree products is found to be efficacious against neurological disorders. This review provides an updated insight on the positive effects of oleuropein against neurodegenerative and neuropsychiatric disorders. The diet practitioners and nutraceutical companies may benefit from the provided information to design and develop strategies to improve the mental health of suffering individuals.

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“…[8][9][10][11] Previous findings indicated that oxidative stress mechanisms can participate in opiate-induced apoptosis that results in neurodegeneration in various brain areas like the hippocampus. [11][12][13][14][15] It has been shown morphine administration in increasing doses may lead to hippocampus CA1, CA2, and CA3 neuronal damage. 16 Also, animal studies have indicated that increases in expression of some proapoptotic proteins such as caspases 3 and Bax as well as decreases in antiapoptotic Bcl-2 protein are involved in morphine-induced apoptosis in the hippocampus.…”

Section: Introductionmentioning

confidence: 99%

The effect of epigallocatechin-3-gallate on morphine-induced memory impairments in rat: EGCG effects on morphine neurotoxicity

et al. 2020

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Aim of study: This investigation evaluated the capacity of epigallocatechin-3-gallate (EGCG) as the main polyphenolic compound in the green tea extract against memory impairment and neurotoxicity in morphine-treated rats. Methods: To measure the EGCG effect (5 and 50 mg/kg, i.p., co-treated with morphine) on spatial learning and memory of morphine-administrated male Wistar rats (45 mg/kg, s.c., 4 weeks), the Morris water maze test was used. Some apoptotic protein levels (Bax, Bcl-2, and cleaved caspase 3) were evaluated in the hippocampus tissue by the Western blot test. Also, oxidative stress status (malondialdehyde level, glutathione peroxidase, and superoxide dismutase activity) was measured in hippocampus tissue. Results: The data presented that EGCG treatment (50 mg/kg) inhibited the morphine-induced memory deficits in rats. Also, EGCG administration reduced the apoptosis and oxidative stress in the hippocampus of morphine-treated rats. Conclusions: Our data indicate that EGCG can improve memory in morphine-treated rats. Molecular mechanisms underlying the detected effects could be related to the prevention of apoptosis and oxidative stress in the hippocampus of morphine-treated rats.

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Effect of oleuropein on morphine-induced hippocampus neurotoxicity and memory impairments in rats

Cited by 26 publications

References 54 publications

Healthy Effects of Plant Polyphenols: Molecular Mechanisms

Healthy Effects of Plant Polyphenols: Molecular Mechanisms

Neuroprotective effects of oleuropein: Recent developments and contemporary research

The effect of epigallocatechin-3-gallate on morphine-induced memory impairments in rat: EGCG effects on morphine neurotoxicity

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