Effect of olive leaf extract treatment on doxorubicin-induced cardiac, hepatic and renal toxicity in rats

Kumral, Alkın; Giriş, Murat; Soluk-Tekkeşin, Merva; Olgaç, Vakur; Doğru‐Abbasoğlu, Semra; Türkoğlu, Ümit; Uysal, Müjdat

doi:10.1016/j.pathophys.2015.04.002

Cited by 55 publications

(30 citation statements)

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“…The result of a study showed that oleuropein decreased the lipid peroxidation in ethanolinduced oxidative stress in rat testis (32). Another study proposed that treatment with OLE reduced MDA level in doxorubicin-induced cardiac, hepatic, and renal toxicity in rats (33). Nasirzadeh and Rasouli reported that oral administration of OLE 100 mg/kg for 30 days decreased MDA level in ovariectomized rats (34).…”

Section: Discussionmentioning

confidence: 99%

Olive Leaves Extract Improved Sperm Quality and Antioxidant Status in the Testis of Rat Exposed to Rotenone

2017

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Section: Discussionmentioning

confidence: 99%

Olive Leaves Extract Improved Sperm Quality and Antioxidant Status in the Testis of Rat Exposed to Rotenone

2017

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“…On the other hand, some limitations in targeted drug delivery 13 result in severe toxicity to liver, kidney and spleen [13][14][15] , as well as the poor distribution of anti-cancer drugs in tumor site 6,16 . Therefore, several strategies like development of some NP-based platforms for targeted drug delivery have been reported 4,17,18 .…”

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confidence: 99%

Combined chemo-magnetic field-photothermal breast cancer therapy based on porous magnetite nanospheres

Sharifi

Hasan

Nanakali

et al. 2020

Sci Rep

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The efficacy of different modalities of treating breast cancer is inhibited by several limitations such as off-targeted drug distribution, rapid drug clearance, and drug resistance. To overcome these limitations, we developed Lf-Doxo-PMNSs for combined chemo-MF-PTT. The PMNSs were synthesized by hydrothermal method and their physicochemical properties were examined by FE-SEM, TEM, DLS, TGA, XRD investigations. The cytotoxicity of as-synthesized NPs against 4T1 cells was carried out by MTT and flow cytometry assays. Afterwards, the anti-cancer activities of as-synthesized Lf-Doxo-PMNSs on the tumor status, drug distribution and apoptosis mechanism were evaluated. The anti-cancer assays showed that Lf-Doxo-PMNSs significantly suppressed the cancer cell proliferation and tumor weight by prolonging drug availability and potential drug loading in tumor cells; whereas they showed a minimum cytotoxicity against non-cancerous cells. Likewise, combined chemo-MF-PTT using Lf-Doxo-PMNSs displayed the highest anti-cancer activity followed by combined chemo-PTT and combined chemo-MF therapy based on altering the apoptosis mechanism. Therefore, these results showed that combined chemo-MF-PTT based on Lf-Doxo-PMNSs can be used as a promising therapeutic platform with potential targeted drug delivery and high loading capacity features as well as reducing cancer drug resistance.

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“…has resulted in significant decrease in BUN, SC and S TP in doxorubicin-induced animals in dosedependent manner thus offering considerable protection against doxorubicin-induced nephrotoxicity. [27][28][29] In the current study ethanol extract of L. culinaris reduced the serum marker levels and reversal of the effects on urinary functional parameters may be due to amelioration of glomerular filtration rate. The nephroprotective mechanism also appears by modulation of various antioxidant parameters thereby ameliorating the antioxidant defense of renal tissue.…”

Section: Discussionmentioning

confidence: 50%

Untitled

Adikay

2016

IJGP

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Objectives: The main objective of current study was to determine the phytoremedial effect of ethanol extract of seeds of Lens culinaris against doxorubicin-induced nephrotoxicity using biochemical and histopathological approaches. Materials and Methods: Ethanol extract of seeds of L. culinaris was prepared by hot extraction method, and preliminary phytochemical studies had been carried out. Nephrotoxicity was induced in male Wistar rats by single intraperitoneal administration of doxorubicin (15 mg/kg b.wt.). Nephroprotector effect of the extract was screened at two different dose levels, i.e. 200 and 400 mg/kg b.wt. by oral administration for 8 days. Nephrotoxicity was assessed by determining blood urea nitrogen (BUN), serum creatinine (SC), serum total protein (S TP ), urinary total protein (U TP ), and urinary creatinine (U Cr ). Renal oxidative stress markers superoxide dismutase (SOD), catalase (CAT), lipid peroxidation (LPO), and glutathione reduced (GSH) were also measured in kidney tissue. Results: The treatment with ethanol extract significantly decreased the levels of BUN, SC, S TP , U TP and LPO which were elevated by doxorubicin induction. In addition, extract also ameliorated the levels of U Cr , SOD, CAT and GSH in dose-dependent manner. Histopathological studies had also substantiated the biochemical parameters. Conclusion: The results suggest that ethanol extract of seeds of L. culinaris possess potent phytoremedial effect against doxorubicin-induced nephrotoxicity.

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Effect of olive leaf extract treatment on doxorubicin-induced cardiac, hepatic and renal toxicity in rats

Cited by 55 publications

References 32 publications

Olive Leaves Extract Improved Sperm Quality and Antioxidant Status in the Testis of Rat Exposed to Rotenone

Olive Leaves Extract Improved Sperm Quality and Antioxidant Status in the Testis of Rat Exposed to Rotenone

Combined chemo-magnetic field-photothermal breast cancer therapy based on porous magnetite nanospheres

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