2012
DOI: 10.1096/fasebj.26.1_supplement.876.8
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Effect of Omega‐3 PUFA on Endothelin‐1 Receptors in Normal and Type 1 Diabetic Rat Hearts

Abstract: Cardiovascular disease is a major complication in diabetes. Its management includes renin‐angiotensin‐system components, endothelial factors (Nitric Oxide), or Endothelin‐1 (ET‐1) regulation. This study focuses on long‐term ET‐1 receptor regulation by ω‐3 and Statin at coronary endothelium (CE) and cardiomyocytes (CM) levels in diabetic rats. Sprague Dawley male rats (n=24) were assigned to 7 groups: normal (N); streptozotocin (STZ)‐induced diabetic (D); normal rats treated with ω‐3 (0.085g/kg) (NO) or Statin … Show more

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