Effect of Omega-3 Supplementation in Patients With Smell Dysfunction Following Endoscopic Sellar and Parasellar Tumor Resection: A Multicenter Prospective Randomized Controlled Trial

Yan, Carol H.; Rathor, Aakanksha; Krook, Kaelyn A.; Ma, Yifei; Rotella, Melissa; Dodd, Robert; Hwang, Peter H.; Nayak, Jayakar V.; Oyesiku, Nelson M.; DelGaudio, John M.; Levy, Joshua M.; Wise, Justin C.; Wise, Sarah K.; Patel, Zara M.

doi:10.1093/neuros/nyz559

Cited by 64 publications

(55 citation statements)

References 40 publications

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“…Alpha lipoic acid (16) has been shown to improve objective tests of olfactory function in a small uncontrolled study. Omega-3 supplementation was found to protective against olfactory loss during the recovery period after skull base surgery, and therefore may have potential in recovery after post-viral loss (17) , although this has not been formally tested. A meta-analysis of 13 studies of olfactory training suggest small to moderate benefit (18) .…”

Section: Discussionmentioning

confidence: 99%

Presentation of New Onset Anosmia During the COVID-19 Pandemic

Hopkins¹,

Šurda²,

Kumar³

2020

Rhin

302

288

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Introduction: Anosmia has not been formally recognised as a symptom of COVID-19 infection. Growing anecdotal evidence suggests increasing incidence of cases of anosmia during the current pandemic, suggesting that COVID-19 may cause olfactory dysfunction. The objective was to characterise patients reporting new onset anosmia during the COVID-19 pandemic Methodology: Design: Survey of 2428 patients reporting new onset anosmia during the COVID-19 pandemic. Setting: Volunteer sample of patients seeking medical advice of recent onset self-diagnosed loss of sense of smell Results: 2428 surveys were completed within 7 days; 64% respondents were under 40. The majority of respondents reported onset of their anosmia in the last week. Of the cohort, 17% did not report any other symptom thought to be associated with COVID-19. In patients who reported other symptoms, 51% reported either cough or fever and therefore met current guidelines for self-isolation Conclusions: Anosmia is reported in conjunction with well-reported symptoms of coronas virus, but 1 in 6 patients with recent onset anosmia report this as an isolated symptom. This might help identify otherwise asymptomatic carriers of disease and trigger targeted testing. Further study with COVID-19 testing is required to identify the proportion of patients in whom new onset anosmia can be attributed to COVID-19

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Section: Discussionmentioning

confidence: 99%

Presentation of New Onset Anosmia During the COVID-19 Pandemic

Hopkins¹,

Šurda²,

Kumar³

2020

Rhin

302

288

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“…Alpha-lipoic acid has been shown to improve the results of objective tests of olfactory function in an uncontrolled study, 30 but its use can be associated with neurological side effects, including headache, dizziness and confusion, which may be difficult to interpret alongside Covid-19 manifestations. Omega-3 supplementation was found to be protective against olfactory loss during the recovery period after skull base surgery and therefore may have potential in aiding recovery after post-viral olfactory loss, 31 although this has not been formally tested in Covid-19 patients. Intranasal vitamin A added to olfactory training resulted in greater rates of improvement compared with olfactory training alone, 32 but it is locally irritant to the nose.…”

Section: Discussionmentioning

confidence: 99%

Smell and taste recovery in coronavirus disease 2019 patients: a 60-day objective and prospective study

et al. 2020

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Background The long-term recovery rate of chemosensitive functions in coronavirus disease 2019 patients has not yet been determined. Method A multicentre prospective study on 138 coronavirus disease 2019 patients was conducted. Olfactory and gustatory functions were prospectively evaluated for 60 days. Results Within the first 4 days of coronavirus disease 2019, 84.8 per cent of patients had chemosensitive dysfunction that gradually improved over the observation period. The most significant increase in chemosensitive scores occurred in the first 10 days for taste and between 10 and 20 days for smell. At the end of the observation period (60 days after symptom onset), 7.2 per cent of the patients still had severe dysfunctions. The risk of developing a long-lasting disorder becomes significant at 10 days for taste (odds ratio = 40.2, 95 per cent confidence interval = 2.204–733.2, p = 0.013) and 20 days for smell (odds ratio = 58.5, 95 per cent confidence interval = 3.278–1043.5, p = 0.005). Conclusion Chemosensitive disturbances persisted in 7.2 per cent of patients 60 days after clinical onset. Specific therapies should be initiated in patients with severe olfactory and gustatory disturbances 20 days after disease onset.

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“…The therapeutic recommendations for patients with sudden onset of olfactory loss are: social isolation in quarantine for at least 14 days, and starting nasal olfactory training as soon as possible 6 . Omega‐3 supplementation might be helpful in recovery after postviral loss because it was found to be protective against olfactory loss during the recovery period after skull‐base surgery 7 . In patients with isolated anosmia, a short course of budesonide nasal irrigations can be prescribed because it has been shown to improve olfactory ability 8 without compromising the local or systemic immune status 9 …”

Section: Olfactory and Taste Lossmentioning

confidence: 99%

Skull‐base surgery during the COVID‐19 pandemic: the Italian Skull Base Society recommendations

Castelnuovo

Turri‐Zanoni

Karligkiotis

et al. 2020

Int Forum Allergy Rhinol

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Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), which causes coronavirus disease 2019 , is highly contagious with devastating impacts for healthcare systems worldwide.Medical staff are at high risk of viral contamination and it is imperative to know what personal protective equipment is appropriate for each situation. Furthermore, elective clinics and operations have been reduced in order to mobilize manpower to the acute specialties combatting the outbreak; appropriate differentiation between patients who require immediate care and those who can receive telephone consultation or whose treatment might viably be postponed is therefore crucial.Italy was one of the earliest and hardest-hit European countries and therefore the Italian Skull Base Society board has promulgated specific recommendations based on consensus best practices and the literature, where available. Only urgent surgical operations are recommended and all patients should be tested at least twice (on days 4 and 2 prior to surgery). For positive patients, procedures should be postponed until after swab test negativization. If the procedure is vital to the survival of the patient, FFP3 and/or PAPRs devices, goggles, full-face visor, double gloves, water-resistant gowns and protective caps, are mandatory. For negative patients, use of at least FFP2 mask is recommended. In all cases the use of drills, which promote the aerosolization of potentially infected mucous particles, should be avoided. Given the potential neurotropism of SARS-CoV-2, dura handling should be minimized. It is only through widely-agreed protocols and teamwork that we will be able to deal with the evolving and complex implications of this new pandemic.

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Effect of Omega-3 Supplementation in Patients With Smell Dysfunction Following Endoscopic Sellar and Parasellar Tumor Resection: A Multicenter Prospective Randomized Controlled Trial

Cited by 64 publications

References 40 publications

Presentation of New Onset Anosmia During the COVID-19 Pandemic

Presentation of New Onset Anosmia During the COVID-19 Pandemic

Smell and taste recovery in coronavirus disease 2019 patients: a 60-day objective and prospective study

Skull‐base surgery during the COVID‐19 pandemic: the Italian Skull Base Society recommendations

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