2007
DOI: 10.3748/wjg.v13.i11.1706
|View full text |Cite
|
Sign up to set email alerts
|

Effect of omeprazole and domperidone on adult asthmatics with gastroesophageal reflux

Abstract: AIM:To study the effect of combined omeprazole (Ome) and domperidone (Dom) therapy on asthma symptoms and pulmonary function in asthmatics with gastroesophageal reflux. METHODS:We selected 198 asthmatics with gastroesophageal reflux diagnosed by 24-h esophageal pH monitoring to receive Ome 20 mg twice daily and Dom 10 mg three times daily or placebo for 16 wk (1:1 double-blind randomization). Spirometry was done at baseline and after 16 wk of treatment. The primary outcome measures were: mean daily daytime and… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

1
20
0
2

Year Published

2008
2008
2021
2021

Publication Types

Select...
7
2

Relationship

0
9

Authors

Journals

citations
Cited by 44 publications
(23 citation statements)
references
References 35 publications
1
20
0
2
Order By: Relevance
“…The treatment of GERD in asthma includes lifestyle modification & use of proton pump inhibitors (PPI) & surgical treatment. (14,15) …”
Section: Discussionmentioning
confidence: 99%
“…The treatment of GERD in asthma includes lifestyle modification & use of proton pump inhibitors (PPI) & surgical treatment. (14,15) …”
Section: Discussionmentioning
confidence: 99%
“…Sharma et al [26] studied 99 asthmatics with GERD and showed that omeprazole 40 mg/day with domperidone 10 mg three times before meal for 16 weeks significantly improved daytime symptoms, nighttime symptoms, PEF and FEV 1 . Gopal et al [11] studied 70 asthmatics with GERD and showed that omeprazole 20 mg/day for 4 weeks significantly improved asthma scores and lung function.…”
Section: Discussionmentioning
confidence: 99%
“…Older prokinetic drugs, metoclopropamide and bethanechol, have frequent side-effects, and cisapride has been withdrawn or restricted in most countries. Domperidone (unavailable in the USA) has been used in the treatment of gastroparesis [125] and as part of a treatment regimen in two small studies of asthmatics with GERD [126,127], but it may prolong the QTc interval [128]. Finally, baclofen reduces the frequency of TLESR in GERD patients [129,130] but, to date, has not been well studied in clinical trials.…”
Section: Managementmentioning
confidence: 99%