2007
DOI: 10.1016/j.cgh.2006.10.025
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Effect of Once- or Twice-Daily MMX Mesalamine (SPD476) for the Induction of Remission of Mild to Moderately Active Ulcerative Colitis

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Cited by 246 publications
(271 citation statements)
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“…No diff erences were seen, however, in complete remission rates between the two dosages ( 134,135 ). Similarly, there were no signifi cant diff erences in clinical responses or remissions in patients with mild or moderate disease when treated with multimatrix-mesalamine with 2.4 g daily compared to 4.8 g daily ( 83,132 ). Th e combination of oral mesalamine and topical mesalamine was more successful than oral mesalamine alone in achieving clinical remission at 8 (but not 4) weeks ( 136 ).…”
Section: Recommendations For Maintenance Of Remission In Distal Diseasementioning
confidence: 83%
See 1 more Smart Citation
“…No diff erences were seen, however, in complete remission rates between the two dosages ( 134,135 ). Similarly, there were no signifi cant diff erences in clinical responses or remissions in patients with mild or moderate disease when treated with multimatrix-mesalamine with 2.4 g daily compared to 4.8 g daily ( 83,132 ). Th e combination of oral mesalamine and topical mesalamine was more successful than oral mesalamine alone in achieving clinical remission at 8 (but not 4) weeks ( 136 ).…”
Section: Recommendations For Maintenance Of Remission In Distal Diseasementioning
confidence: 83%
“…Th e " newer " aminosalicylates -balsalazide ( 82,88,89 ), olsalazine ( 90 -93 ), Eudragit-S-coated, pH-dependent mesalamine ( 54,87 ), ethylcellulose-coated mesalamine ( 131 ), and multimatrix-release mesalamine ( 83,132 ) -are all superior to placebo and equivalent to sulfasalazine in acute therapy ( 80 ). As with sulfasalazine, therapeutic benefi t requires a threshold dose, with daily doses less than 2 g being ineff ective ( 54,80,87,133 ).…”
Section: Recommendations For Maintenance Of Remission In Distal Diseasementioning
confidence: 99%
“…In a large randomized, double-blind, placebo-controlled trial, Lichtenstein et al [35] investigated the efficacy of MMX mesalazine 1.2 g twice daily and 4.8 g once-daily compared with a placebo for 8 wk, for the induction of remission in patients with mild-to moderate UC. Both MMX mesalazine groups achieved statistically significant clinical and endoscopic remission compared with the placebo (34.1% and 29.2% vs 12.9%, 2.4 g/d and 4.8 g/d vs placebo, P < 0.001 and P = 0.009, respectively).…”
Section: Mesalazinementioning
confidence: 99%
“…Of the 434 MMX mesalazine recipients evaluated for safety in the four published controlled trials [13][14][15][16][17][18][19][20][21] , only two patients had serious adverse events that were considered treatment-related; both included pancreatitis caused by hypersensitivity to mesalazine. There was no evidence of a dose-response relationship with MMX mesalazine for any tolerability parameter in either trial.…”
Section: Maintenance Of Remissionmentioning
confidence: 99%
“…The FDA's approval of MMX mesalazine (SPD476, MezavantTM, LialdaTM) was based on the two randomized, double-blind, placebo-controlled Phase Ⅲ trials [15,16] . The first trial investigated the efficacy of MMX mesalazine 1.2 g twice daily and 4.8 g once-daily compared with the placebo for eight weeks, for the induction of remission in 280 patients with mild-tomoderate UC.…”
Section: Maintenance Of Remissionmentioning
confidence: 99%