Effect of ondansetron on spinal anesthesia-induced hypotension in non-obstetric surgeries: a randomised, double-blind and placebo-controlled trial

Mendonça, Fabrício Tavares; Crepaldi, Luis Carlos; Gersanti, Rafaela Carvalho; Araújo, Kamila Christine de

doi:10.1016/j.bjane.2020.12.028

Cited by 6 publications

(8 citation statements)

References 30 publications

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“…In addition, we found that patients treated with ondansetron had a lower need for vasopressor administration and a lower dosage of administered ephedrine, which were consistent with previous studies [9,12]. This was mainly attributed to the lower incidence of hypotension.…”

Section: Discussionsupporting

confidence: 91%

“…Notably, 18 additional trials were omitted for the following reasons: conference abstracts (n = 3) [16][17][18] and no available outcomes (n = 15) [6,8,14,[19][20][21][22][23][24][25][26][27][28][29]. Finally, a total of 25 trials that satisfied the eligibility requirements were selected for inclusion in the metaanalysis [2,[11][12][13]. The schematic of the process of literature screening is depicted in Figure 1.…”

Section: Search Resultsmentioning

confidence: 99%

“…However, the activation of the Bezold-Jarisch reflex is one of the important mechanisms of hypotension after spinal anaesthesia. Numerous studies have focused on preventing hypotension by attenuating the Bezold-Jarisch reflex with 5-HT3 receptor antagonists [2,[11][12][13]30,39,46,47,49,53]. Ondansetron was demonstrated to be effective in preventing hypotension in previous metaanalyses [9,10,54,55].…”

Section: Discussionmentioning

confidence: 99%

“…However, in the aforementioned studies, the sample sizes were relatively small. Furthermore, significant resources have been utilised annually on clinical trials on this topic worldwide [6,7,[11][12][13][14]. Therefore, we conducted this systemic review and meta-analysis using trial sequential analysis (TSA) to investigate whether ondansetron prevents hypotension following spinal anaesthesia.…”

Section: Introductionmentioning

confidence: 99%

“…Figure 6. Forest plot of the pooled analysis showing the dose of administered ephedrine [12,13,30,48]. …”

mentioning

confidence: 99%

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Ondansetron Reduces the Incidence of Hypotension after Spinal Anaesthesia: A Systematic Review and Meta-Analysis

et al. 2022

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Hypotension induced by spinal anaesthesia is a common clinical complication associated with multiple perioperative adverse events. We conducted a systemic review and meta-analysis to confirm whether ondansetron could alleviate hypotension following spinal anaesthesia. PubMed, Embase, Web of Science, and Cochrane Library were searched to identify eligible randomised controlled trials from their respective database inception dates to 30 September 2022. The primary outcome of the meta-analysis was the incidence of hypotension after spinal anaesthesia. The risk of bias in the included studies was evaluated using the revised Cochrane risk of bias tool for randomised trials (RoB 2.0). Grading of Recommendations, Assessment, Development, and Evaluation was applied to assess the level of certainty. A total of 25 studies were included in this research. The meta-analysis revealed that ondansetron significantly decreased the incidence of hypotension (RR = 0.65, 95% CI 0.53–0.80, p < 0.01, I2 = 64%) and bradycardia. In addition, patients treated with ondansetron had a reduced need for vasopressors administration. This study suggests that ondansetron may be recommended as a prophylaxis for hypotension and bradycardia following spinal anaesthesia; the level of evidence was moderate with a high level of heterogeneity.

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Section: Discussionsupporting

confidence: 91%

Section: Search Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Figure 6. Forest plot of the pooled analysis showing the dose of administered ephedrine [12,13,30,48]. …”

mentioning

confidence: 99%

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Ondansetron Reduces the Incidence of Hypotension after Spinal Anaesthesia: A Systematic Review and Meta-Analysis

et al. 2022

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Research Progress on Prevention and Mechanism of Hypotension after Spinal An-esthesia

董

2023

ACM

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Pengaruh Aromaterapi Lavender terhadap Kecemasan pada Pasien Pra-Operasi Sectio Caesarea dengan Anestesi Spinal

Sari,

Yuliastuti,

Widyastuti

et al. 2023

jurkes

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Kecemasan pada pasien pra-operasi sectio caesarea biasanya diakibatkan oleh adanya rasa khawatir tentang dirinya maupun keadaan bayinya. Aromaterapi lavender merupakan salah satu terapi komplementer dan teknik non-farmakologi untuk mengurangi kecemasan. Tujuan penelitian ini yaitu untuk mengetahui pengaruh aromaterapi lavender terhadap kecemasan pada pasien pre operasi sectio caesarea dengan anestesi spinal. Penelitian ini merupakan penelitian kuantitatif yang menggunakan metode eksperimen dengan desain rancangan one group pretest posttest. Teknik pengambilan sampel dalam penelitian ini adalah purposive sampling dengan sampel berjumlah 22 responden. Instrumen yang digunakan berupa APAIS (The Amsterdam Preoperative Anxiety and Information Scale). Analisis data dilakukan dengan uji statistik Wilcoxon. Hasil dari penelitian ini didapatkan nilai p 0,000 < α 0,05. Hal ini berarti aromaterapi lavender berpengaruh terhadap penurunan tingkat kecemasan pada pasien pra-operasi sectio caesarea. Minyak lavender dapat memberikan efek relaksasi bagi saraf dan otot-otot yang tegang.

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Effect of ondansetron on spinal anesthesia-induced hypotension in non-obstetric surgeries: a randomised, double-blind and placebo-controlled trial

Cited by 6 publications

References 30 publications

Ondansetron Reduces the Incidence of Hypotension after Spinal Anaesthesia: A Systematic Review and Meta-Analysis

Ondansetron Reduces the Incidence of Hypotension after Spinal Anaesthesia: A Systematic Review and Meta-Analysis

Research Progress on Prevention and Mechanism of Hypotension after Spinal An-esthesia

Pengaruh Aromaterapi Lavender terhadap Kecemasan pada Pasien Pra-Operasi Sectio Caesarea dengan Anestesi Spinal

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