Effect of one-off complete tumor radiofrequency ablation on liver function and postoperative complication in small hepatocellular carcinoma

Upregulation of PDGF Mediates Robust Liver Regeneration after Nanosecond Pulsed Electric Field Ablation by Promoting the HGF/c-Met Pathway

“…In particular, the proliferation of cells was more obvious within the periablational area which was featured by the accumulation of activated HSCs. Unfortunately, RFA has been reported to lead to great and lasting damage to liver function [17], and this side effect is a huge challenge and cannot be neglected when RFA is applied to treat liver lesions. As an analogue to RFA, nsPEF ablation on the liver also had an impact on liver function in the first 3 days after ablation.…”

Unroofing hepatectomy: A facilitating approach for resection of deep‐seated hepatocellular carcinoma adjacent to major intrahepatic vessels in cirrhotic patients

“…This modality may be appropriate for the tumor size of some group A patients, but ablation of tumor at this location risked injury to the adjacent vessels. Subsequent higher complication and liver dysfunction rates after RFA for HCC near the intrahepatic vessels (<5 mm in distance) have been reported . Moreover, tract seeding by percutaneous route may occur .…”

“…dysfunction rates after RFA for HCC near the intrahepatic vessels (<5 mm in distance) have been reported [37]. Moreover, tract seeding by percutaneous route may occur [3,37]. TACE is an another nonoperative modality for HCC.…”

Predictive factors for the success of "one-off" ablation in single hepatocellular carcinoma patients who underwent percutaneous radiofrequency ablation

“…Tumor location included deep-parenchyma (307 patients, 66.5%) and sub-capsular (155 patients, 43.5%). Among them, 109 (23.6%) tumors were close to organs (space between tumor and organ < 1 cm) [13] (22 nodules close to stomach, 48 close to gallbladder, 23 close to jejunum, 8 close to pericardium, and 17 close to kidney), and 40 tumors (3.9%) were close to the main blood vessels (between tumor and vessels < 5 mm) [11] such as post-hepatic vena cava, hepatic vein, and the portal vein.…”

“…Herein, we adopted a new terminology named "one-off " ablation, which was proposed by Jiang et al [9][10][11] and defined as achieving complete necrosis after a singlesession of RFA with no local residual or recurrent tumor within 6 months. The present retrospective study tried to investigate the predictive factors related to the success of "one-off " ablation.…”