Effect of one-time high load exercise on skeletal muscle injury in rats of different genders: oxidative stress and mitochondrial responses

Wang, Yuan; Chen, Mengmeng; Gao, Yan; He, Kang; Yang, Zhaoyun; Li, Yuewei; Zhang, Shuang; Zhao, Lijing

doi:10.1590/acb370805

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…The mechanically gated ion channel, Piezo1, converts mechanical signals received at the cell membrane into electrical or chemical signals that are transmitted to the intracellular compartment followed by causing a series of biochemical reactions. Muscle injury can be induced through apoptosis ( 17 ). Piezo1 may play a role in the apoptosis process during skeletal muscle injury, where decreased Piezo1 expression leads to more apoptotic skeletal muscle cells after injury ( 18 ).…”

Section: Efficacy Of Chinese Medicine Rehabilitation In Peripheral Ne...mentioning

confidence: 99%

Advances in novel biomaterials combined with traditional Chinese medicine rehabilitation technology in treatment of peripheral nerve injury

Liu,

Hu,

Huang

et al. 2024

Front. Neurol.

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Peripheral nerve injuries (PNI) represent one of the primary neuropathies leading to lifelong disability. Nerve regeneration and targeted muscle atrophy stand as the two most crucial factors influencing functional rehabilitation post peripheral nerve injury. Over time, traditional Chinese medicine (TCM) rehabilitation approaches such as acupuncture, Tuina, and microneedles serve as pivot means to activate the regeneration of injured nerve Schwann cells. By promoting axon regeneration, these approaches can accomplish nerve repair, reconstruction, and functional rehabilitation. Although TCM rehabilitation approaches have clinically demonstrated effectiveness in promoting the repair and regeneration of PNI, the related molecular mechanisms remain unclear. This significantly hampers the application and promotion of TCM rehabilitation in PNI recovery. Therefore, deeply delving into the cellular and molecular mechanisms of TCM rehabilitation technologies to foster nerve regeneration stands as the most pressing issue. On the other hand, in recent years, novel biomaterials represented by hydrogels, microfluidic platforms, and new chitosan scaffolds have showed their unique roles in treating various degrees of nerve injury. These methods exhibit immense potential in conducting high-throughput cell and organoid culture in vitro and synthesizing diverse tissue engineering scaffolds and drug carriers. We believe that the combination of TCM rehabilitation technology and novel biomaterials can more effectively address precise treatment issues such as identification of treatment target and dosage control. Therefore, this paper not only summarizes the molecular mechanisms of TCM rehabilitation technology and novel biomaterials in treating peripheral nerve injury individually, but also explores the research direction of precise treatment by integrating the two at both macro and micro levels. Such integration may facilitate the exploration of cellular and molecular mechanisms related to neurodegeneration and regeneration, providing a scientific and theoretical foundation for the precise functional rehabilitation of PNI in the future.

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Section: Efficacy Of Chinese Medicine Rehabilitation In Peripheral Ne...mentioning

confidence: 99%

Advances in novel biomaterials combined with traditional Chinese medicine rehabilitation technology in treatment of peripheral nerve injury

Liu,

Hu,

Huang

et al. 2024

Front. Neurol.

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Synergistic Effects of Omega-3 Fatty Acids and Physical Activity on Oxidative Stress Markers and Antioxidant Mechanisms in Aged Rats

Paduchová,

Gajdošová,

Katrenčíková

et al. 2024

Nutrients

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Background: Aging induces degenerative processes in the body, contributing to the onset of various age-associated diseases that affect the population. Inadequate dietary habits and low physical activity are major contributors to increased morbidity during aging. This study aimed to investigate the combined effects of omega-3 fatty acid supplementation and physical activity on the markers of oxidative stress and antioxidant defense mechanisms in aged male Wistar rats (23–24 months). Methods: The rats were randomly divided into four experimental groups: a sedentary control (placebo, no exercise), a trained (placebo and moderate-intensity graded aerobic exercise; Ex), and two trained groups supplemented with low (160 mg/kg of body weight; O1 + Ex) and high (320 mg/kg of body weight; O2 + Ex) doses of omega-3 fatty acids. The biochemical and functional parameters related to sarcopenia and the markers of oxidative stress were measured in blood and gastrocnemius muscle. Results: The results demonstrated dose-dependent, synergistic effects of omega-3 fatty acid supplementation and physical activity. The higher dose (320 mg/kg of body weight) improved plasma antioxidant capacity (TEAC, +21.01%, p < 0.01) and GPx activity (+78.05%, p < 0.05) while reducing CAT activity in erythrocytes (−19.92%, p < 0.05), likely as an adaptive stress response. Combined interventions also normalized cholesterol levels, improved the functional parameters of sarcopenia (stride length, +14.82%, p < 0.001), and enhanced antioxidant protection in aged rats. Conclusions: These findings highlight the potential of combining omega-3 fatty acid supplementation and physical activity to counteract aging-related degenerative changes. Further research is needed to elucidate the underlying mechanisms and evaluate the long-term benefits of these strategies in aging populations.

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Mechanism of static loading injury in human skeletal muscle cells

Yuan

2024

Am J Transl Res

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Effect of one-time high load exercise on skeletal muscle injury in rats of different genders: oxidative stress and mitochondrial responses

Cited by 3 publications

References 36 publications

Advances in novel biomaterials combined with traditional Chinese medicine rehabilitation technology in treatment of peripheral nerve injury

Advances in novel biomaterials combined with traditional Chinese medicine rehabilitation technology in treatment of peripheral nerve injury

Synergistic Effects of Omega-3 Fatty Acids and Physical Activity on Oxidative Stress Markers and Antioxidant Mechanisms in Aged Rats

Mechanism of static loading injury in human skeletal muscle cells

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