Effect of onion flavonoids on colorectal cancer with hyperlipidemia: an in vivo study

He, Yongshan; Jin, Hei-Ying; Gong, Wei; Zhang, Chunxia; Zhou, A-Cheng

doi:10.2147/ott.s51835

Cited by 10 publications

(8 citation statements)

References 28 publications

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“…The antihyperlipidemic property of flavonoids has equally been confirmed in cancer engendered dyslipidemia. 75 In addition to these studies, Ma et al 76 proposed the possible mechanism by which flavonoids display these therapeutic properties. They noted that the capability of flavonoids from Morus indica to normalize blood lipids and glucose concentrations of high fat diet/low dose STZ-induced hyperlipidemic and hyperglycemic rats, were in connection with the upregulation of hepatic superoxide dismutase activity, reduction of hepatic malondialdehyde content, downregulation of hepatic CYP2E1 expression, and increase of glucose transporter 4 (GLUT-4) expression in skeletal muscle of the treated rats.…”

Section: Discussionmentioning

confidence: 99%

Blood glucose level and lipid profile of alloxan-induced hyperglycemic rats treated with single and combinatorial herbal formulations

Ojiako

Chikezie

Ogbuji

2016

Journal of Traditional and Complementary Medicine

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The current study sought to investigate the capacities of single and combinatorial herbal formulations of leaf extracts of Acanthus montanus, Asystasia gangetica, Emilia coccinea, and Hibiscus rosasinensis to reverse hyperglycemia and dyslipidemia in alloxan-induced diabetic male rats. Phytochemical composition of the herbal extracts, fasting plasma glucose concentration (FPGC), and serum lipid profile (SLP) of the rats were measured by standard methods. The relative abundance of phytochemicals in the four experimental leaf extracts was in the following order: flavonoids > alkaloids > saponins > tannins. Hyperglycemic rats (HyGR) treated with single and combinatorial herbal formulations showed evidence of reduced FPGC compared with the untreated HyGR and were normoglycemic (FPGC < 110.0 mg/dL). Similarly, HyGR treated with single and combinatorial herbal formulations showed evidence of readjustments in their SLPs. Generally, HyGR treated with triple herbal formulations (THfs) exhibited the highest atherogenic index compared with HyGR treated with single herbal formulations (SHfs), double herbal formulations (DHfs), and quadruple herbal formulation (QHf). The display of synergy or antagonism by the composite herbal extracts in ameliorating hyperglycemia and dyslipidemia depended on the type and number of individual herbal extract used in constituting the experimental herbal formulations. Furthermore, the capacities of the herbal formulations (SHfs, DHfs, THfs, and QHf) to exert glycemic control and reverse dyslipidemia did not follow predictable patterns in the animal models.

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Section: Discussionmentioning

confidence: 99%

Blood glucose level and lipid profile of alloxan-induced hyperglycemic rats treated with single and combinatorial herbal formulations

Ojiako

Chikezie

Ogbuji

2016

Journal of Traditional and Complementary Medicine

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“…The lack of a strong association between flavonoid intake and oesophageal or colorectal cancer is particularly surprising because numerous in vitro and animal studies have demonstrated an inverse association between flavonoid and oesophageal or colorectal cancer 34 35 36 37 . However, many flavonoids present in foods cannot be absorbed in their native form, including esters, glycosides, and polymers 38 .…”

Section: Discussionmentioning

confidence: 99%

Dietary flavonoid intake and the risk of digestive tract cancers: a systematic review and meta-analysis

Bo¹,

Sun²,

Wang³

et al. 2016

Sci Rep

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Several epidemiological studies have investigated the association between dietary flavonoid intake and digestive tract cancers risk; however, the results remain inconclusive. The aim of our study was to evaluate this association. PubMed and the Web of Knowledge were searched for relevant publications from inception to October 2015. The risk ratio (RR) or odds ratio (OR) with the 95% confidence interval (95% CI) for the highest versus the lowest categories of flavonoid intake were pooled using a fixed-effects model. A total of 15 articles reporting 23 studies were selected for the meta-analysis. In a comparison of the highest versus the lowest categories of dietary flavonoid intake, we found no significant association between flavonoid intake and oesophageal cancer (OR = 0.91, 95% CI = 0.75–1.10; I2 = 0.0%), colorectal cancer (OR = 1.02, 95% CI = 0.92–1.14, I2 = 36.2%) or gastric cancer (OR = 0.88; 95% CI = 0.74–1.04, I2 = 63.6%). The subgroup analysis indicated an association between higher flavonoid intake and a decreased risk of gastric cancer in the European population (OR = 0.78, 95% CI = 0.62–0.97). In conclusion, the results of this meta-analysis do not strongly support an association between dietary flavonoid intake and oesophageal or colorectal cancer. Furthermore, the subgroup analysis suggested an association between higher dietary flavonoid intake and decreased gastric cancer risk in European population.

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“…In vivo result showed a significant reduction in the tumor growth in the mice by 38% after 2 weeks (Kim et al, 2015). Another study on onion flavonoids extract showed a promising result, whereby onion's extraction inhibits the proliferation of CRC in new established orthotopic transplant animal model (He et al, 2014). However, among all vegetables, cruciferous vegetables have received much interest due to the unique contents of high glucosinolate which can be metabolized to isothiocyanates (ITCs) and indole-3-carbinol (I3C) by myrosinaseexpressing colonic bacteria.…”

Section: Vegetablesmentioning

confidence: 98%

“…It is well established that consumption of a certain type of fruit which contains high amount of fiber, folate, vitamins, minerals and antioxidants can act as a chemo-preventive agents against CRC (Song et al, 2015). Studies on pomegranate and its bioactive products have yielded contestant and significant findings against CRC in vitro, in vivo and in clinical trials (Jaganathan et al, 2014;Molina et al, 2015).Apple and its active componentpolysaccharides has been found to reduce the DNA damage in the distal colon of dimethylhydrazine (DMH)-initiated rats, and also decrease the hyperproliferation of human colon carcinoma cells (HT-29) via induced cell-cycle block in a P53 (Li et al, 2015). Similarly, black raspberry seeds and their active constituents have successfully suppressed the growth of HT-29 cells by up upregulation of P21 and activation of caspase 3, 8 and 9 (Cho et al, 2015).…”

Section: Fruitsmentioning

confidence: 99%

The Impact of Life Style and Nutritional Components in Primary Prevention of Colorectal Cancer

Dahham¹,

Majid²

2016

J App Pharm Sci

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Colorectal cancer (CRC) is one of the most aggressive malignant solid tumors which remain a rampant killer across the world. Toxic drugs have failed to reduce the morbidity and mortality rate of CRC patients. In addition, adoption of cancer-causing behaviors has increased the globule burden of CRC. Inappropriate lifestyle such as, smoking, obesity, physical inactivity, alcohol consumption and poor dietary components, all of which have been reported to aggravate the CRC incidence worldwide. In this regard, there is a growing awareness and increasing interest in cancer prevention approaches focusing on environmental and behavioral interventions, where specific carcinogenic factors implicated in cancer initiation, promotion, and progression may be triggered. In this communication, we report the role of lifestyle patterns and nutritional components in the modulation of CRC, and discuss the possible biological mechanism which involves in CRC pathogenesis. The findings indicate that smoking and alcohol consumption release a wide range of carcinogenic compounds such as, polynuclear aromatic hydrocarbons and acetaldehyde which can cause DNA damage and alter the function of tumor suppressor genes. Moreover, the link between obesity and CRC has been detected in several studies, whereby obesity induces insulin resistance and hyperglycemia, resulted in NF-κB and IGF-1 activation. In contrast, an inverse association between physical activity and cancer incidence has been constantly observed; the risk of CRC has been reduced 10-60% in the regular physical activity. With respect to nutritional components, compelling evidence indicates that avoidance of high intake of processed red meat, highly refined grains, starches, sugar and salt, and replacing them with poultry, fish, unrefined grains, legumes, vegetables, and fruits are strongly associated with lower risks of CRC.

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Effect of onion flavonoids on colorectal cancer with hyperlipidemia: an in vivo study

Cited by 10 publications

References 28 publications

Blood glucose level and lipid profile of alloxan-induced hyperglycemic rats treated with single and combinatorial herbal formulations

Blood glucose level and lipid profile of alloxan-induced hyperglycemic rats treated with single and combinatorial herbal formulations

Dietary flavonoid intake and the risk of digestive tract cancers: a systematic review and meta-analysis

The Impact of Life Style and Nutritional Components in Primary Prevention of Colorectal Cancer

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