Effect of OPC-12759, a novel antiulcer agent, on chronic and acute experimental gastric ulcer, and gastric secretion in rats.

Yamasaki, K.; Ishiyama, H.; Imaizumi, Tsutomu; Kanbe, Toshimi; Yabuuchi, Youichi

doi:10.1254/jjp.49.441

Cited by 81 publications

(54 citation statements)

References 27 publications

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“…Although we investigated whether wogonin also influenced regenerating actions in damaged mucosa, no significant influences of wogonin pretreatment on the expression of vascular endothelial growth factor proteins (data not shown) were not observed except for a slight induction of HSP70 after 30 mg/kg wogonin treatment, similar to rebamipide (10,31,32). We also checked the changes in gastric mucin with immunohistochemical staining; there was no significant induction of any kind of mucin proteins after wogonin treatment despite small increases in expression, suggesting that the major action of wogonin against alcohol-induced gastropathy was antiinflammation.…”

Section: Discussionmentioning

confidence: 94%

“…Based on known antiinflammatory and apoptosis inducing activities of wogonin, we investigated whether wogonin can prevent alcohol-induced gastritis in rats and compared the preventive effects of wogonin against alcohol stomach injury with the efficacy of rebamipide, a wellknown drug prescribed clinically for the treatment of gastritis and gastric ulcer (10,31).…”

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confidence: 99%

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Preventive Effect of the Flavonoid, Wogonin, Against Ethanol-Induced Gastric Mucosal Damage in Rats

Park

Hahm

et al. 2004

Dig Dis Sci

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Whether wogonin (5,7-dihydroxy-8-methoxyflavone), a flavonoid originated from the root of Scutellaria baicalensis Georgi, which has been shown to have antiinflammatory and antitumor activities in various cell types, possesses a gastric cytoprotective effect was investigated in an ethanol-induced gastric damage model in rats. Ethanol administration alone induced evident gastric damage including gastric hemorrhages and edema, while this gastric damage was significantly attenuated by wogonin pretreatment (30 mg/kg B.W.) 1 hr before ethanol administration. As major protective mechanisms of wogonin on ethanol-induced gastric damage, we found that wogonin showed either antiinflammatory effects through dual actions on arachidonic acid metabolism, i.e., induction of prostaglandin D 2 and suppression of 5S-hydroxyeicosatetraenoic acid (5S-HETE), or preventive induction of profuse apoptosis in the stomach. Conclusively, the flavonoid wogonin could be used as a preventive agent of alcohol-induced gastropathy, whose actions were proven to be strong antiinflammation and apoptosis induction.

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Section: Discussionmentioning

confidence: 94%

mentioning

confidence: 99%

Preventive Effect of the Flavonoid, Wogonin, Against Ethanol-Induced Gastric Mucosal Damage in Rats

Park

Hahm

et al. 2004

Dig Dis Sci

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“…significantly reduced gastric mucosal hemorrhagic lesions induced by intragas tric H202. It has also been reported that rebamipide can prevent gastric mucosa developing from acute gastric mu cosal lesions induced by ethanol and aspirin (9,10), which are thought to generate reactive oxygen metabolites (3,4). Recently, Yoshikawa et al (12) indicated that rebamipide has a potent activity to scavenge the hydroxyl radical, which is thought to be one of the most toxic free radicals.…”

Section: Resultsmentioning

confidence: 99%

“…Rebamipide is a protective antiulcer agent with activ ities to increase prostaglandin level in gastric mucosa and stimulate mucus secretion (9,20,21). In this study, re bamipide at 30 and 100 mg/kg, i.p.…”

Section: Resultsmentioning

confidence: 99%

“…Rebamipide has been reported to prevent various acute experimental gastric mucosal lesions and to accelerate the heeling of chronic gastric ulcers (9,10). Ogino et al (11) showed that the antiulcer effect of rebamipide might be related to the inhibition of the production of reactive oxy gen species by activated neutrophils in a diethyldithio carbamate-induced antral ulcer model in rats.…”

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confidence: 99%

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Protective Effect of Rebamipide against Hydrogen Peroxide-Induced Hemorrhagic Mucosal Lesions in Rat Stomach

Sakurai

Yamasaki

1994

Japanese Journal of Pharmacology

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ABSTRACT-Intragastric administration of 6°1o H202 induces gastric mucosal hemorrhagic lesions in rats. Intraperitoneal administration of rebamipide at 10 to 100 mg/kg dose-dependently prevented the H202 induced mucosal lesions. The fact that cimetidine, ranitidine and omeprazole could not prevent the gastric mucosa from developing H202-induced lesions indicates that acid secretion might not be the main cause of these lesions. The protective effect of rebamipide was partially reduced by indomethacin and completely blocked by diethyl maleate, a glutathione depressor. Gastric mucosal glutathione level and glutathione peroxidase and superoxide dismutase (SOD) activities were significantly decreased by 6% H202 instillation. Rebamipide at 100 mg/kg significantly inhibited the decreases in gastric mucosal glutathione level and SOD activity. These results suggest that H202-induced gastric mucosal lesions might partially involve a decrease in defense activities against reactive oxygen species and that the protective effect of rebamipide might be related to its ability to improve oxidative stress in gastric mucosa.

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Combinatorial Use of Sodium Laurate with Taurine or L‐Glutamine Enhances Colonic Absorption of Rebamipide, Poorly Absorbable Antiulcer Drug, without Any Serious Histopathological Mucosal Damages

Miyake

Oka

Minami

et al. 2003

Journal of Pharmaceutical Sciences

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Effect of OPC-12759, a novel antiulcer agent, on chronic and acute experimental gastric ulcer, and gastric secretion in rats.

Cited by 81 publications

References 27 publications

Preventive Effect of the Flavonoid, Wogonin, Against Ethanol-Induced Gastric Mucosal Damage in Rats

Preventive Effect of the Flavonoid, Wogonin, Against Ethanol-Induced Gastric Mucosal Damage in Rats

Protective Effect of Rebamipide against Hydrogen Peroxide-Induced Hemorrhagic Mucosal Lesions in Rat Stomach

Combinatorial Use of Sodium Laurate with Taurine or L‐Glutamine Enhances Colonic Absorption of Rebamipide, Poorly Absorbable Antiulcer Drug, without Any Serious Histopathological Mucosal Damages

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