Effect of ophthalmic solution components on acrylic intraocular lenses

Abstract

The chemical components of ophthalmic solutions, such as surfactants and solvents, permeate acrylic IOLs, suggesting the potential for long-term adverse effects of eyedrops in pseudophakic eyes.

Cytotoxicity of ophthalmic solutions with and without preservatives to human corneal endothelial cells, epithelial cells and conjunctival epithelial cells

“…Preservatives for ophthalmic solutions include benzalkonium chloride, chlorobutanol, parahydroxybenzoates and polysorbate. We previously reported the potential of ophthalmic solution ingredients to damage intraocular lenses 1 . In the present report we provide evidence that certain ophthalmic solution ingredients are cytotoxic to endothelium.…”

“…We previously reported the potential of ophthalmic solution ingredients to damage intraocular lenses. 1 In the present report we provide evidence that certain ophthalmic solution ingredients are cytotoxic to endothelium. Numerous reports describe clinical manifestations that suggest preservative cytotoxicity.…”

Glistenings and surface light scattering in intraocular lenses

“…Indeed, 97% of patients with glaucoma in the study used antiglaucoma medications. Active ingredients or preservatives in antiglaucoma medications may lead to rupture of the BAB 36 or may have a direct effect on the IOL material, as indicated in the study of antiinflammatory agents by Ayaki et al 19,34 Colin et al 35 did not find that the presence of the blue light-filtering chromophore in yellow AcrySof IOLs affected the incidence or severity of glistenings.…”

“…Later, the same group performed an in vitro study to investigate the effect of ophthalmic solutions and ophthalmic solution components on 3 hydrophobic acrylic IOLs: AcrySof MA30BA, Sensar AR40 (Abbott Medical Optics, Inc.), and Acryfold (Hoya Surgical Optics GmbH). 34 The active components investigated were diclofenac sodium, bromfenac sodium, betamethasone phosphate, and dibekacin sulphate. Polysorbate 80 (surfactant), benzalkonium chloride (preservative/ surfactant), methyl parahydroxybenzoate (preservative), and propyl parahydroxybenzoate (preservative) were also evaluated.…”

A comparison of mesopic visual acuity and objective visual quality following cataract surgery with hydrophobic acrylic intraocular lenses

“…This may be due in part to chronic use of antiglaucoma topical medications used to lower IOP. Active ingredients or preservatives in glaucoma medications may either directly or indirectly affect the composition of aqueous humor, thereby inducing glistenings 21,22. Schweitzer et al have also reported that the incidence and severity of glistenings in glaucomatous eyes were significantly associated with the number of topical antiglaucoma medications instilled daily 23…”