Effect of oral administration of haloperidol on plasma thyrotropin concentrations in men

Magliozzi, Joseph R.; Gold, Anita S.; Laubly, Justine N.

doi:10.1016/0306-4530(89)90061-9

Cited by 8 publications

(3 citation statements)

References 16 publications

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“…Moreover, it has been suggested that dopamine may be inhibitory of TSH secretion [59], as treatment with dopamine blockers lead to increase in TSH level or to subclinical hypothyroidism [79], and that hypothyroidism can lead to increased dopamine receptor sensitivity [74]. In a human study of acutely ill schizophrenic patients, Rao et al [55] analyzed the interrelation between serum levels of dopamine, prolactin, TSH, and T 4 .…”

Section: Thyroid Hormones and Schizophrenia: Relationship With Neumentioning

confidence: 99%

Revisiting Thyroid Hormones in Schizophrenia

Santos

Costa

Ruano

et al. 2012

Journal of Thyroid Research

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Thyroid hormones are crucial during development and in the adult brain. Of interest, fluctuations in the levels of thyroid hormones at various times during development and throughout life can impact on psychiatric disease manifestation and response to treatment. Here we review research on thyroid function assessment in schizophrenia, relating interrelations between the pituitary-thyroid axis and major neurosignaling systems involved in schizophrenia's pathophysiology. These include the serotonergic, dopaminergic, glutamatergic, and GABAergic networks, as well as myelination and inflammatory processes. The available evidence supports that thyroid hormones deregulation is a common feature in schizophrenia and that the implications of thyroid hormones homeostasis in the fine-tuning of crucial brain networks warrants further research.

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Section: Thyroid Hormones and Schizophrenia: Relationship With Neumentioning

confidence: 99%

Revisiting Thyroid Hormones in Schizophrenia

Santos

Costa

Ruano

et al. 2012

Journal of Thyroid Research

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“…It is particularly interesting to relate the pituitary-thyroid axis with the dopaminergic hypothesis of schizophrenia. Increased dopaminergic activity inhibits TSH pituitary secretion (Rao et al, 1984), and dopamine blockers result in subclinical hypothyroidism (Magliozzi et al, 1989) while hypothyroidism induces increased dopamine receptor sensitivity (Crocker et al, 1986). A recent report demonstrated that hypothyroid rats are unable to switch the conversion of excitatory to inhibitory hippocampus dopamine receptors, which can be reversed by administration of T 4 .…”

Section: Thyroid Hormones Retinoids and Schizophreniamentioning

confidence: 99%

Thyroid hormones and retinoids: A possible link between genes and environment in schizophrenia

Palha

Goodman

2006

Brain Research Reviews

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Phenotypic discordance for schizophrenia in monozygotic twins clearly indicates involvement of environmental factors as key determinants in disease development. Positive findings from genome scans, linkage and association studies apply in only a minority of those affected, while post-mortem brain investigations reveal altered expression of genes and proteins involved in numerous neurodevelopmental, metabolic and neurotransmitter pathways. Such altered expressions could result, on the one hand, from mutations in coding regions or polymorphisms in the promoter and regulatory regions in genes within those areas identified by gene searches or, on the other hand, from inadequate amounts of modulators, transporters and synthesizers of transcription factors necessary for regulation of the putative genes. Hormones and vitamins are such modulators. They could serve as bridges between genes and environment in schizophrenia. Multiple evidence supports the suggestion of retinoids and thyroid hormones as plausible actors in these roles. Both are not only essential for normal development of the central nervous system but also regulate the expression of many neurotransmitters, their synthesizing enzymes and receptors, and other genes in broader signaling transduction cascades affecting pathways that are altered in response to treatment. Functional and positional candidate genes include retinoic acid and thyroid hormone receptors, retinaldehyde dehydrogenases and deiodinases, which synthesize the powerful morphogens, retinoic acid and triiodothyronine, and the enzymes involved in their inactivation. This review highlights selective evidence supporting the retinoid and thyroid hormone hypotheses of schizophrenia.

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“…The data on changes in basal and TRH-stimulated TSH levels with neuroleptic treatment are variable. Treatment with different classical neuroleptics is associated with increases [10,11], no change [12] and decreases [13] in basal TSH levels. In Germany, zotepine has been available as a moderately potent neuroleptic.…”

Section: Introductionmentioning

confidence: 99%