Effect of Oral Administration of Emtricitabine on Woodchuck Hepatitis Virus Replication in Chronically Infected Woodchucks

Abstract

Emtricitabine [(؊)FTC] [(؊)-

Viral Pharmacodynamic Model for (–)-β-2′,3′-Dideoxy-5-Fluoro-3′-Thiacytidine (Emtricitabine) in Chronically Infected Woodchucks

“…These data were part of a larger study of the antiviral effect of (-)-FTC in chronically infected woodchucks (Korba et al, 2000a).…”

“…Chronic WHV infections were derived by neonatal inoculation of animals as previously described (Korba et al, 1987(Korba et al, , 2000aSummers et al, 1990;Kajino et al, 1994). All woodchucks used in these studies were chronically infected with WHV at the start of treatment with (-)-FTC.…”

“…(-)-FTC was administered in a liquid diet mixture by oral gavage. Woodchucks (two males and two females per group) were treated once daily with 1, 3, 10 or 30 mg/kg per day over 28 days as described previously (Korba et al, 1987(Korba et al, ,2000a). …”

“…(-)-β-2′,3′-dideoxy-5-fluoro-3′-thiacytidine [emtricitabine, Coviracil, (-)-FTC] has potent and selective antiviral activity against HBV, WHV and HIV-1 in vitro and in vivo Schinazi et al, 1992Schinazi et al, , 1994Darque et al, 1999;Korba et al, 2000a;Molina et al, 2000). The aim of this study was to develop an IRP-KPD_ECB model to describe virus depletion and recovery in woodchucks chronically infected with WHV, as a function of time and dose during treatment with (-)-FTC.…”

“…WHV-infected woodchucks are one of the most useful animal models for studying the pathology of HBV and for the development of antiviral nucleosides for treating HBV infections (Korba et al, 1987(Korba et al, , 2000aMason & Taylor, 1989;Seeger et al, 1991;Kajino et al, 1994;Roggendorf & Tolle, 1995;Schinazi et al, 1997Schinazi et al, ,1999Hurwitz et al, 1998;Tennant et al, 1998). Nowak et al (1996) used a system of three differential equations that incorporated viral loads, the number of …”