Effect of oral administration of β-glucans derived from Aureobasidium pullulans SM-2001 in model mice and rat with atopic dermatitis-like phenotypes

Kim, In Sung; Lee, Seung Ho; Kim, Jeong Ah; Yu, Da Yoon; Hong, Yeon Hee; Kim, Jae Young; Lim, Jong Min; Lee, Sang-Suk; Yun, Cheol‐Heui; Choi, Inhee; Cho, Kwang Keun

doi:10.1007/s10068-018-0322-4

Cited by 8 publications

(12 citation statements)

References 33 publications

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“…Various strains of lactic acid bacteria have been reported to reduce allergic symptoms in mouse models and humans [19,20]. Previously, we have demonstrated that oral administration of β-1,3/1,6-glucan from Aureobasidium pullulans SM-2001 effectively attenuates AD-like phenotypes in animal models [21]. However, studies on the potential variation in the bioactivity of β-1,3/1,6-glucans from different sources and the synergistic immunomodulatory effects of β-1,3/1,6-glucan and L. plantarum on AD are still lacking.…”

Section: Introductionmentioning

confidence: 96%

Oral Administration of ¥ Glucan and Lactobacillus plantarum Alleviates Atopic Dermatitis-Like Symptoms

Kim

Lee

Kwon

et al. 2019

Journal of Microbiology and Biotechnology

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Atopic dermatitis (AD) is a chronic inflammatory skin disease of mainly infants and children. Currently, the development of safe and effective treatments for AD is urgently required. The present study was conducted to investigate the immunomodulatory effects of yeast-extracted β-1,3/1,6-glucan and/or Lactobacillus plantarum (L. plantarum) LM1004 against AD-like symptoms. To purpose, β-1,3/1,6-glucan and/or L. plantarum LM1004 were orally administered to AD-induced animal models of rat (histamine-induced vasodilation) and mouse (pruritus and contact dermatitis) exhibiting different symptoms of AD. We then investigated the treatment effects on AD-like symptoms, gene expression of immune-related factors, and gut microbiomes. Oral administration of β-1,3/1,6-glucan (0.01 g/kg initial body weight) and/or 2 × 10 1 2 cells/g L. plantarum LM1004 (0.01 g/kg initial body weight) to ADinduced animal models showed significantly reduced vasodilation in the rat model, and pruritus, edema, and serum histamine in the mouse models (p < 0.05). Interestingly, β-1,3/1,6glucan and/or L. plantarum LM1004 significantly decreased the mRNA levels of Th2 and Th17 cell transcription factors, while the transcription factors of Th1 and Treg cells, galactin-9, filaggrin increased, which are indicative of enhanced immunomodulation (p < 0.05). Moreover, in rats with no AD induction, the same treatments significantly increased the relative abundance of phylum Bacteroidetes and the genus Bacteroides. Furthermore, bacterial taxa associated with butyrate production such as, Lachnospiraceae and Ruminococcaceae at family, and Roseburia at genus level were increased in the treated groups. These findings suggest that the dietary supplementation of β-1,3/1,6-glucan and/or L. plantarum LM1004 has a great potential for treatment of AD as well as obesity in humans through mechanisms that might involve modulation of host immune systems and gut microbiota.

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Section: Introductionmentioning

confidence: 96%

Oral Administration of ¥ Glucan and Lactobacillus plantarum Alleviates Atopic Dermatitis-Like Symptoms

Kim

Lee

Kwon

et al. 2019

Journal of Microbiology and Biotechnology

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“…On the other hand, the improvement of the skin lesion in the Synbio-glucan dietary treatment was significantly lower. Previous studies confirmed that the oral administration of β-glucan and probiotics alleviated AD significantly [ 14 , 27 ]. In the present study, the scores of skin lesions were similar to those of the positive control, but histological analysis showed improvement of the skin lesion compared to the control group.…”

Section: Discussionmentioning

confidence: 64%

“…Previous studies confirmed that this type of β-glucan prevents obesity and reduces blood glucose, cholesterol concentrations, and body weight [ 22 , 23 ]. Some studies used β-glucan to treat or prevent atopic dermatitis in vivo, but the β-glucan used was derived from algae and yeast not from cereals, such as oats [ 14 , 15 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have applied β-glucan to a range of allergic diseases [ 13 ], but its efficacy against AD is controversial. One study reported that the oral administration of β-glucan derived from yeast ( Aureobasidium pullulans ) has anti-AD effects in animal models [ 14 ]. Another study indicated anti-AD effects through the topical administration of β-glucan derived from mushroom, Pleurotus ostreatus , on human patients [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Anti-Inflammatory and Immune Modulatory Effects of Synbio-Glucan in an Atopic Dermatitis Mouse Model

et al. 2021

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Many trials have been conducted to treat atopic dermatitis (AD), but these therapies are generally unsuccessful because of their insufficiency or side effects. This study examined the efficacy of β-glucan derived from oats with fermented probiotics (called Synbio-glucan) on an AD-induced mouse model. For the experiment, Nc/Nga mice were exposed to a house dust mite extract (HDM) to induce AD. The mice were placed in one of four groups: positive control group, Synbio-glucan topical treatment group, Synbio-glucan dietary treatment group, and Synbio-glucan topical + dietary treatment group. The experiment revealed no significant difference in the serum IgE concentration among the groups. Serum cytokine antibody arrays showed that genes related to the immune response were enriched. A significant difference in the skin lesion scores was observed between the groups. Compared to the control group tissue, skin lesions were alleviated in the Synbio-glucan topical treatment group and Synbio-glucan dietary treatment group. Interestingly, almost normal structures were observed within the skin lesions in the Synbio-glucan topical + dietary treatment group. Overall, the β-glucan extracted from oats and fermented probiotic mixture is effective in treating atopic dermatitis.

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“…The animal behavior did not change during the research. In these studies, the topical use of some substances (DNCB, DNFB and DEE) (13,15,18,(20)(21)(22)(23)(24)26), some nutrients (cow milk, red Korean ginseng) (16,21), UV radiations (25) and injections with Apigenin (19) could explain the appearance of skin lesions in AD.…”

Section: Discussionmentioning

confidence: 99%

Importance of food in the control of inflammation in atopic dermatitis

2020

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Patients that suffer from inflammatory diseases need to pay special attention to nutrition. For this reason, it is very important to change the approach of both health professionals and food industry specialists. There must be a close collaboration, starting from research, the development phase of foods for special nutrition states. Our primary objective was to identify foods or potential dietary ingredients, which efficacy in the treatment of atopic dermatitis had been scientifically demonstrated in vitro, in vivo and clinically. Furthemore, our perspective is presented regarding the research and development of foods for special nutritional states in atopic dermatitis. The PubMed database was analyzed for the period 2018-2020, as well as the European Legislation regarding the appropriate requirements for the composition and knowledge applicable to foods destined for use in special medical purposes. The search criteria were 'chronic dermatitis', 'atopic dermatitis', 'psoriasis', 'alternative treatments', 'natural treatments', 'complementary treatments', 'treatments for chronic dermatitis'. We also looked for undesirable effects or side effects of the foods included in the research in order to treat atopic dermatitis. The results showed that prebiotics, probiotics and certain plant extracts had a high efficacy in controlling inflammation in atopic dermatitis. The food development research for special nutrition states (atopic dermatitis) involves a multidisciplinary team. We started with the establishment of the general objective and continued with the consultation of the PubMed, EMBASE and other databases, and with the in vitro, preclinical and/or clinical determination of the efficacy of new developed foods, that must be protected with patents. The development of foods for special nutrition states represents a solution for improving the quality of life of atopic dermatitis patients.

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Effect of oral administration of β-glucans derived from Aureobasidium pullulans SM-2001 in model mice and rat with atopic dermatitis-like phenotypes

Cited by 8 publications

References 33 publications

Oral Administration of ¥ Glucan and Lactobacillus plantarum Alleviates Atopic Dermatitis-Like Symptoms

Oral Administration of ¥ Glucan and Lactobacillus plantarum Alleviates Atopic Dermatitis-Like Symptoms

Anti-Inflammatory and Immune Modulatory Effects of Synbio-Glucan in an Atopic Dermatitis Mouse Model

Importance of food in the control of inflammation in atopic dermatitis

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