Effect of Oral Administration of Lactiplantibacillus plantarum SNK12 on Temporary Stress in Adults: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Study

Watanabe, Taiji; Hayashi, Kyoko; Takara, Tsuyoshi; Teratani, Takumi; Kitayama, Joji; Kawahara, Toshio

doi:10.3390/ijerph19158936

Cited by 6 publications

(1 citation statement)

References 58 publications

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“…High dose of Lactiplantibacillus plantarum SNK12 (3 × 10 10 CFU/day) was reported to have led to greater improvement of psychological status than low dose (1 × 10 10 CFU/day). [ 25 ] The dose of this study was only 1 × 10 10 CFU/day. This could be problematic because a part of the probiotics taken orally is killed in gastric juice and the amount of surviving probiotics would not reveal the sufficient effects.…”

Section: Discussionmentioning

confidence: 99%

Leuconostoc mesenteroides subsp. strain NTM048 ameliorated nasal symptoms in patients with Japan cedar pollinosis: Randomized, double-blind, and placebo-controlled trial

Yamamoto,

Sugita,

Hiraoka

et al. 2023

Medicine

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Background: Lactobacillales including L mesenteroides have beneficial effects on human health, including improvement of psychological status and alleviation of allergic rhinitis. In mice, L mesenteroides subsp. strain NTM048 (NTM048) increased intestinal s-IgA. In humans, however, the effects of NTM048 on s-IgA secretion have been unclear. Study: This 16-week trial was performed using a double-blind, placebo-controlled, parallel group design. We aimed to establish whether Leuconostoc mesenteroides subsp. strain NTM048 increases the secretion of s-IgA in saliva. Forty healthy adults and forty patients with Japanese cedar pollinosis were recruited. Participants took either 2 test capsules including NTM048 (1010 CFU/day), or 2 placebo capsules per day, for 16 weeks. They were asked to collect their saliva and answered POMS2, a questionnaire about psychological status. The patients also answered questions about nasal symptoms. Blood samples were collected from the patients with Japanese Cedar pollinosis. Stool samples were collected at the start and on the last day of the trial. Results: All subjects completed the trial. It was conducted during the season when Japanese cedar pollen is most scattered. Serum concentration of Japanese cedar pollen-specific IgE was > 2.0 UA/mL in patients with Japanese cedar pollinosis. The amount of s-IgA in saliva was not increased by NTM048 in overall subjects, and Japanese cedar pollen-specific IgE was not changed by NTM048 in patients with Japanese cedar pollinosis. The symptom of nasal blockage was improved by NTM048 12 weeks after the start of trial. post hoc analysis indicated a positive correlation between improving psychological status and the increase in occupation ratio of lactobacillus including NTM048. Conclusion: The amount of s-IgA in saliva was not increased by NTM048, but nasal blockage was improved by it. Psychological status might be improved if dosage of NTM048 is raised to the degree that NTM048 might be increased in the intestinal tract.

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Section: Discussionmentioning

confidence: 99%

Leuconostoc mesenteroides subsp. strain NTM048 ameliorated nasal symptoms in patients with Japan cedar pollinosis: Randomized, double-blind, and placebo-controlled trial

Yamamoto,

Sugita,

Hiraoka

et al. 2023

Medicine

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Psychological and Physiological Effects of Low-Level Meaningful Artificial Sounds on Intellectual Tasks

Asakura

2023

Acoust Aust

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The present study aimed to investigate the psychological and physiological effects of low-level meaningful artificial sounds on intellectual tasks. The psychological factors related to the degree of disturbance, concentration, and stress, as measured by subjective evaluation, were compared with the degree of physiological stress, as measured using salivary alpha-amylase activity. The results indicated that human speech and chewing sounds caused similar levels of psychological stress while performing intellectual tasks; however, chewing sounds caused comparatively less physiological stress than did human speech sounds. These findings suggest that depending on the sound stimulus, psychological and physiological stress characteristics may not coincide.

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Audiovisual effects of roadside tree plantings on perception of road traffic sounds

Asakura

2024

Applied Acoustics

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Effect of Oral Administration of Lactiplantibacillus plantarum SNK12 on Temporary Stress in Adults: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Study

Cited by 6 publications

References 58 publications

Leuconostoc mesenteroides subsp. strain NTM048 ameliorated nasal symptoms in patients with Japan cedar pollinosis: Randomized, double-blind, and placebo-controlled trial

Leuconostoc mesenteroides subsp. strain NTM048 ameliorated nasal symptoms in patients with Japan cedar pollinosis: Randomized, double-blind, and placebo-controlled trial

Psychological and Physiological Effects of Low-Level Meaningful Artificial Sounds on Intellectual Tasks

Audiovisual effects of roadside tree plantings on perception of road traffic sounds

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