Effect of oral administration of terephthalic acid on testicular functions of rats

Leaching of the plasticizer di(2-ethylhexyl)phthalate (DEHP) from plastic containers and the question of human exposure

“…Figure 1 shows that the two carbonyl functions of terephthalic acid are in para-position to one another, on opposite ends of the aromatic ring. Terephthalic acid was originally reported to be nontoxic (Hoshi et al 1968), but later studies involving higher levels of exposure to this compound suggested that it may impair testicular functions (Cui et al 2004). An extensive review on terephthalic acid has been recently published (Ball et al 2011).…”

Toxicity of purified terephthalic acid manufacturing wastewater on reproductive system of male mice (Mus musculus)

“…However, relative testes weights were reported to show no significant variation in the rats treated with TA [8], a main component in PTA wastewater. Lamb et al [22] found that PA esters could induce significant effects on relative liver weight.…”

“…Among the components in PTA wastewater, TA can cause bladder stones and bladder cancer [6,7], as well as impairment of testicular functions [8]. Information is unavailable about the reproductive toxicity induced by p-CBA, but the compound p-Tol was found to cause the decrease of epididymal weight and the increase of incidence in cauda epididymal oligo/azoospermia [9].…”

Genomic expression profiles in liver of mice exposed to purified terephthalic acid manufacturing wastewater

“…It has been indicated that exposure to PTA wastewater and the aromatic components can cause impairment of liver [6], bladder [7], testis [8] and kidney [9], as well as DNA damage [10]. Our previous studies also showed that PTA manufacturing wastewater had reproductive toxicities on mice, including reduction in relative testes weight and percentage of viable spermatogenic cells, histopathological abnormalities, alteration in germ cell percentage and sperm shape abnormality [11].…”

“…Our previous studies also showed that PTA manufacturing wastewater had reproductive toxicities on mice, including reduction in relative testes weight and percentage of viable spermatogenic cells, histopathological abnormalities, alteration in germ cell percentage and sperm shape abnormality [11]. Currently, toxicological detection of these pollutants is mainly dependent on traditional methods, including histopathological observation [7], haematological analysis [8] and epidemiological investigation [12].…”