Effect of oral administration of gabapentin on the minimum alveolar concentration of isoflurane in dogs

Johnson, Brittney A.; Aarnes, Turni K.; Wanstrath, Audrey W.; Pereira, Carolina H. Riccó; Bednarski, Richard M.; Lerche, Phillip; McLoughlin, Mary M.

doi:10.2460/ajvr.80.11.1007

Cited by 12 publications

(7 citation statements)

References 28 publications

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“…The effects of intravenous gabapentin administration on the MAC ISO in cats have been investigated, but no significant differences were identified at any of the target plasma concentrations ( 17 ). This finding contradicts our findings and previous studies in dogs and rats ( 16 , 31 ). The cause for the difference in MAC-sparing effect between oral and intravenous administration of gabapentin is unclear, and additional study is warranted to investigate the effect and mechanism of different gabapentin administration routes on MAC in cats.…”

Section: Discussioncontrasting

confidence: 99%

“…Gabapentin (100 mg cat −1 ) perorally administered 2 h before starting MAC determination maintained with isoflurane significantly reduced MAC ISO by 31.58 ± 6.94% compared with the placebo treatment. This finding is in agreement with a previous study in dogs that oral gabapentin (20 mg kg −1 ) had a 20 ± 14% MAC-sparing effect ( 16 ). The MAC ISO range for cats was reported to be between 1.20 ± 0.13% and 2.22 ± 0.35%, while the mean MAC ISO in cats was 1.71 ± 0.07% ( 28 ).…”

Section: Discussionsupporting

confidence: 94%

“…Perorally administered gabapentin (20 mg kg −1 ) 2 h before general anesthesia maintained with isoflurane was shown to have a MAC-sparing effect in dogs ( 16 ). However, intravenous gabapentin administration was reported to have no detectable effects on MAC ISO in cats ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

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Effect of oral administration of gabapentin on the minimum alveolar concentration of isoflurane in cats

Chen

Yang²,

Li³

et al. 2023

Front. Vet. Sci.

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ObjectiveTo determine if oral gabapentin decreases the minimum alveolar concentration (MAC) of isoflurane in cats.Study designProspective, randomized, blinded, crossover, and experimental study.AnimalsA total of six healthy adult cats (three male, three female) aged 18–42 months, weighing 3.31 ± 0.26 kg.MethodsCats were randomly given oral gabapentin (100 mg cat−1) or placebo 2 h before starting MAC determination, with the crossover treatment given at least 7 days apart. Anesthesia was induced and maintained with isoflurane in oxygen. Isoflurane MAC was determined in duplicate using an iterative bracketing technique and tail clamp method. Hemodynamic and other vital variables were recorded at each stable isoflurane concentration and were compared between gabapentin and placebo treatments at lowest end-tidal isoflurane concentration when cats did not respond to tail clamping. A paired t-test was used to compare normally distributed data, and a Wilcoxon signed-rank test was applied for non-normally distributed data. Significance was set at p < 0.05. Data are mean ± standard deviation.ResultsIsoflurane MAC in the gabapentin treatment was 1.02 ± 0.11%, which was significantly lower than that in the placebo treatment (1.49 ± 0.12%; p < 0.001), decreasing by 31.58 ± 6.94%. No significant differences were found in cardiovascular and other vital variables between treatments.Conclusion and clinical relevanceOral administration of gabapentin 2 h before starting MAC determination had a significant isoflurane MAC-sparing effect in cats with no observed hemodynamic benefit.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 94%

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Effect of oral administration of gabapentin on the minimum alveolar concentration of isoflurane in cats

Chen

Yang²,

Li³

et al. 2023

Front. Vet. Sci.

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“…23 In dogs, Gabapentin is a known as an anticonvulsant 24 and effective in pain management. [25][26][27] In a study including six dogs, 28 gabapentin was also useful during anaesthetic protocols by sparing the minimum alveolar concentration of isoflurane. The mechanism of its pharmacological effects is only partially understood.…”

Section: Introductionmentioning

confidence: 99%

Effects of a single oral dose of gabapentin on storm phobia in dogs: A double‐blind, placebo‐controlled crossover trial

Bleuer-Elsner

Medam²,

Masson³

2021

Veterinary Record

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Background: Storm phobia in companion dogs is a common disorder that significantly impacts dogs' welfare. Gabapentin, the action of which is only partially understood, is widely used for its antiepileptic and analgesic properties. Only recently, the veterinary community began to use gabapentin to address phobia and anxiety in dogs. This study tested gabapentin to lower fear responses of dogs during a thunderstorm event. Methods: Eighteen dogs suffering from storm phobia completed our doubleblind, placebo-controlled crossover trial. Each dog's behaviour was evaluated twice by his owner: once under placebo, once under gabapentin. The treatment was orally administered at least 90 min before the exposure. Gabapentin was given at a dose ranging from 25 to 30 mg/kg. Results: Our results indicate a significant reduction of the fear responses of dogs under gabapentin. The adverse effects were rare, and the most frequent amongst them was ataxia. Conclusion:In this trial, gabapentin appears to be an efficient and safe molecule that should be considered as part of the treatment plan of storm phobia in dogs.

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“…7 However, in a study assessing the use of gabapentin as an adjuvant in dogs undergoing mastectomy, Crociolli and colleagues found a significant difference in rescue analgesia requirements, 13 supporting a role for gabapentin (10 mg/kg, orally) in acute postoperative pain management. Additionally, gabapentin, 20 mg/kg, administered orally, 2 hours prior to maintenance of anaesthesia with isoflurane, has been shown to reduce the minimum alveolar concentration of isoflurane in dogs 25 ; however, this effect may simply be associated with the drug's depressant effect on the central nervous system.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Gabapentin in the Treatment of Postoperative Pain after a Tibial Plateau Levelling Osteotomy in Dogs

2023

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Objective Pain management is an essential component of perioperative patient care. Multimodal pain management strategies have the potential to provide more effective analgesia than a single drug. The objective of this study was to evaluate the use of gabapentin as an adjuvant to carprofen for the management of postoperative pain following tibial plateau levelling osteotomy surgery. Materials and Methods The study included 20 adult dogs with unilateral cranial cruciate ligament disease, assigned to one of two postoperative treatment groups, receiving either carprofen (4.4 mg/kg orally every 24 hours) or carprofen plus gabapentin 20 mg/kg, orally, every 8 hours beginning the night prior to surgery and continuing for 14 days postoperatively. The patients were blindly assessed postoperatively using the Short Form of the Glasgow Composite Measure Pain Scale (GCMPS-SF) and limb function measured by pressure platform gait analysis. There was no difference in body weight, age, affected hindlimb or sex between groups. Result No differences were found in (GCMPS-SF) pain assessments; after surgery, a (GCMPS-SF) more than or equal to 6 was documented in four dogs (two dogs in each group) and no dog required rescue analgesia more than once. Conclusion In this population of dogs, the addition of oral gabapentin at the dose and frequency studied did not improve subjective or objective outcome measures for perioperative pain control following tibial plateau levelling osteotomy surgery.

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Effect of oral administration of gabapentin on the minimum alveolar concentration of isoflurane in dogs

Cited by 12 publications

References 28 publications

Effect of oral administration of gabapentin on the minimum alveolar concentration of isoflurane in cats

Effect of oral administration of gabapentin on the minimum alveolar concentration of isoflurane in cats

Effects of a single oral dose of gabapentin on storm phobia in dogs: A double‐blind, placebo‐controlled crossover trial

Evaluation of Gabapentin in the Treatment of Postoperative Pain after a Tibial Plateau Levelling Osteotomy in Dogs

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