Effect of oral administration of arabic gum on cisplatin‐induced nephrotoxicity in rats

Abstract

It has been recently postulated from our laboratory that Arabic gum (AG) offers a protective effect in the kidney of rats against nephrotoxicity induced by gentamicin via inhibiting lipid peroxidation. It has also recently shown a powerful antioxidant effect through scavenging superoxide anions. In this study we utilized a rat model of cisplatin (CP)-induced nephrotoxicity to determine its peak time following (1, 2, 5, and 7 days) of a single CP (7.5 mg/kg, i.p.) injection. Also, a possible protective effect of cotreatment with AG (7.5 g/kg/day p.o.) on CP-induced nephrotoxicity was investigated. Biochemical as well as histological assessments were carried out. CP-induced nephrotoxicity was manifested by significant elevations of the functional parameters blood urea, serum creatinine, and kidney/body weight ratio. Maximum toxic effects of CP were observed 5 days after its injection, while it started after day 1 in the biochemical parameters, such as glutathione depletion in the kidney tissue with concomitant increases in lipid peroxides and platinum content. Additionally, severe necrosis and desquamation of tubular epithelial cells in renal cortex as well as interstitial nephritis were observed after 5 days in CP-treated animals. Five days after AG cotreatment with CP did not protect the kidney from the damaging effects of CP. However, it significantly reduced CP-induced lipid peroxidation. These findings suggest that lipid peroxidation is not the main cause of CP-induced nephrotoxicity but it is rather more dependent on other factors such as platinum disposition in renal interstitial tubules.

Protective Effects of Capsaicin against Cisplatin-Induced Nephrotoxicity in Rats

“…These data are in good agreement with previous studies. 4,[12][13][14][21][22][23] Although the mechanism of CDDP-induced nephrotoxicity is exactly unknown, several studies have suggested that the nephrotoxicity is induced by lipid peroxidation and free radicals. On the other hand, many antioxidants have been shown to be protective against CDDP-induced nephrotoxicity.…”

“…On the other hand, many antioxidants have been shown to be protective against CDDP-induced nephrotoxicity. [12][13][14] Also, various free radical scavengers have been shown to be effective in protection against CDDP-induced nephrotoxicity, and treatment with such agents provides significant protection against CDDP-induced acute renal failure. 4,24) Cap and its analogues have more effective antioxidant activity.…”

“…[12][13][14] The purpose of the present study was to investigate whether the administration of Cap exerts any protective effect against cisplatin-induced lipid peroxidation and nephrotoxicity in rats.…”

Schisandrin B Enhances Renal Mitochondrial Antioxidant Status, Functional and Structural Integrity, and Protects against Gentamicin-Induced Nephrotoxicity in Rats

“…A huge body of experimental evidence has suggested that reactive oxygen species (ROS) are involved in the pathogenesis of gentamicin nephrotoxicity. 5,9) In this regard, gentamicin was found to enhance the production of hydrogen peroxide by rat renal cortical mitochondria in vitro.…”

Pharmacological inhibition of NADPH oxidase protects against cisplatin induced nephrotoxicity in mice by two step mechanism

“…Common antioxidant N-acetylcysteine, Vitamin E, Carvedilol protects against cisplatin induced renal damage (Abdelrahman et al, 2010;Appenroth et al, 1997;Carvalho Rodrigues et al, 2012;Carvalho Rodrigues et al, 2013;Nematbakhsh and Nasri, 2013;Riga et al, 2013). Broccoli derived sulforaphane, fruit derived fisetin, asian spice derived curcumin, capsaicin and arabic gum prevents cisplatin induced nephropathy (Al-Majed et al, 2003;Gaona-Gaona et al, 2011;Guerrero-Beltran et al, 2010Jung et al, 2014;Kursunluoglu et al, 2014;Sahu et al, 2014;Trujillo et al, 2013). Transcriptional regulator NRF2 and its target heme oxygenase-1 have critical role in cisplatin mediated renal damage (Aleksunes et al, 2010;Sahin et al, 2010aSahin et al, , 2010bShiraishi et al, 2000).…”